Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Dianne M. Kenney"'
Publikováno v:
Blood. 100:2763-2768
Wiskott-Aldrich syndrome (WAS) is an X-linked disease characterized by thrombocytopenia, eczema, and various degrees of immune deficiency. Carriers of mutated WASP have nonrandom X chromosome inactivation in their blood cells and are disease-free. We
Autor:
Eileen Remold-O'Donnell, Fred S. Rosen, Dianne M. Kenney, Jessica Cooley, L.N. Jones, Maxim I. Lutskiy
Publikováno v:
Blood Cells, Molecules, and Diseases. 28:392-398
Mutations of WASP (Wiskott-Aldrich syndrome protein) underlie the severe immunodeficiency/platelet disorder Wiskott-Aldrich syndrome (WAS) and its milder variant X-linked thrombocytopenia (XLT). The affected gene, a 12-exon structure on the X-chromos
Publikováno v:
British Journal of Haematology. 106:216-223
The Wiskott-Aldrich syndrome (WAS) is a severe disease of platelets (small size, thrombocytopenia) and lymphocytes (immunodeficiency) arising from mutations of the X-chromosome gene WASP. Because of the prominent role of cytoskeletal abnormalities, p
Autor:
Dianne M. Kenney
Publikováno v:
Current Opinion in Pediatrics. 2:931-934
Publikováno v:
Pediatric pulmonology. 39(2)
Neutrophil elastase is present at high levels in airway fluid of patients with cystic fibrosis (CF), and is responsible for considerable inflammatory damage. Human monocyte/neutrophil elastase inhibitor (MNEI), a 42-kDa serpin protein, is an effectiv
Autor:
Jessica Cooley, Rick A. Rogers, Eileen Remold-O'Donnell, Dianne M. Kenney, Dianne D. Rees, Robert J. Mandle
Publikováno v:
American journal of respiratory cell and molecular biology. 20(1)
Human monocyte/neutrophil elastase inhibitor (M/NEI) is a fast-acting stoichiometric inhibitor of neutrophil elastase (NE), cathepsin-G, and proteinase-3. Recombinant M/NEI (rM/NEI) was evaluated with a rat model of NE-induced lung damage. rM/NEI was
Publikováno v:
Pediatric Pulmonology; Feb2005, Vol. 39 Issue 2, p141-149, 9p
Publikováno v:
Thrombosis and Haemostasis. 32:216-231
SummaryThe effects of varying concentrations of platelets, fibrinogen and thrombin on platelet aggregation and on fibrin clotting were investigated. The results indicated that a threshold thrombin to platelet concentration ratio may be required to ca
Publikováno v:
Blood. 69:479-485
Sixty-eight patients with malignant disease were divided into two groups based on the results of the platelet antithrombin test (PAT). The normal group had a PAT clotting time ranging from 21.4 to 29.8 seconds, which was equivalent to 25% to 65% inac
Autor:
F S Rosen, Beverley Savage, Dianne M. Kenney, Lloyd Cairns, Robertson Parkman, Eileen Remold-O'Donnell
Publikováno v:
The Journal of Experimental Medicine
gpL115 is a lymphocyte surface component that is deficient in patients with the X-chromosome-linked immune deficiency Wiskott-Aldrich syndrome (6). The glycoprotein nature of gpL115 is demonstrated through labeling in carbohydrate moieties by [3H]NaB