Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Dianne DeVincentis"'
Publikováno v:
Tetrahedron. 64:7871-7876
An efficient synthesis of Ecopladib, an indole inhibitor of cytosolic phospholipase A2α, is described. A new reaction involving indole C3 reductive alkylation using an acetal in the absence of water and a novel transformation of the C2 methyl to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ccb4d6bc06ffc1b71702c168b66afc25
https://doi.org/10.1016/j.tet.2008.06.045
https://doi.org/10.1016/j.tet.2008.06.045
Autor:
Xuemei Du, Thomas S. Rush, Tam Steve Yik-Kai, Yonghan Hu, Dianne DeVincentis, Jennifer R. Thomason, Kristina Cunningham, Jason Shaoyun Xiang, Jeremy I. Levin, Jianchang Li, Elisabeth A. Morris, Wei Li, Jerauld S. Skotnicki, Priya S. Chockalingam
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4961-4966
The structure-based design and synthesis of a series of novel biphenyl sulfonamide carboxylic acids as potent MMP-13 inhibitors with selectivity over MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-14, Aggrecanase 1, and TACE are described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b44ddefc7ea6586738dcff00b25091c
https://doi.org/10.1016/j.bmcl.2005.08.001
https://doi.org/10.1016/j.bmcl.2005.08.001
Autor:
Priya S. Chockalingam, Elisabeth A. Morris, Tam Steve Yik-Kai, Dianne DeVincentis, Thomas S. Rush, Yonghan Hu, Rajeev Hotchandani, Jianchang Li, Jeremy I. Levin, Xuemei Du, Jennifer R. Thomason, Junjun Wu, Wei Li, Jerauld S. Skotnicki
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(16)
Potent 3,4-disubstituted benzofuran P1' MMP-13 inhibitors have been prepared. Selectivity over MMP-2 was achieved through a substituent at the C4 position of the benzofuran P1' moiety of the molecule. By replacing a backbone benzene with a pyridine a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa04bb234c31678e0e0445bc2a83bc8
https://pubmed.ncbi.nlm.nih.gov/19625186
https://pubmed.ncbi.nlm.nih.gov/19625186
Publikováno v:
ChemInform. 35
The conversion of dihalomethylarenes to the corresponding aldehydes is accomplished conveniently by using sulfoxides as the oxygen donor under neutral conditions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6ca3aaee673afe6916d3a720e238acd
https://doi.org/10.1002/chin.200419071
https://doi.org/10.1002/chin.200419071