Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Dianne Alewood"'
Autor:
Maite Amado, Tzong-Hsien Lee, Martin J. Scanlon, Jennifer R. Deuis, Brian A. Baldo, Dianne Alewood, Alysha G. Elliott, Zoltan Dekan, Paul F. Alewood, Stephen J. Headey, Marie-Isabel Aguilar, Irina Vetter, Mark E. Cooper
Publikováno v:
Angewandte Chemie International Edition. 56:8495-8499
Delta-Myrtoxin-Mp1a (Mp1a), a 49-residue heterodimeric peptide from the venom of Myrmecia pilosula, comprises a 26-mer A chain and a 23-mer B chain connected by two disulfide bonds in an antiparallel arrangement. Combination of the individual synthet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf555a321d69b7f9ccf615130877e28b
https://doi.org/10.1002/anie.201703360
https://doi.org/10.1002/anie.201703360
Autor:
Daniel E. Croker, Richard J. Lewis, Roger Drinkwater, Barbara Colless, Christina I. Schroeder, Maree T. Smith, Elka Palant, Dianne Alewood, Carsten K. Nielsen, Paul F. Alewood, Brad Patterson, Andreas Brust, David Wilson
Publikováno v:
Journal of Medicinal Chemistry. 52:6991-7002
Norepinephrine (NE) amplifies the strength of descending pain inhibition, giving inhibitors of spinal NET clinical utility in the management of pain. chi-MrIA isolated from the venom of a predatory marine snail noncompetitively inhibits NET and rever
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03ab71c72a55e63daacd16ae7b4e3b86
https://doi.org/10.1021/jm9003413
https://doi.org/10.1021/jm9003413
Autor:
Shu-Hong Hu, Jennifer L. Martin, Terry Walsh, Leonard Keith Pattenden, David P. Fairlie, Joel D. A. Tyndall, Robert Reid, Paul F. Alewood, Dianne Alewood
Publikováno v:
Biochemistry. 47:3736-3744
HIV-1 protease is a key target in treating HIV infection and AIDS, with 10 inhibitors used clinically. Here we used an unusual hexapeptide substrate, containing two macrocyclic tripeptides constrained to mimic a beta strand conformation, linked by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c35aab61b27a5985da5bf2d16d0f52
https://doi.org/10.1021/bi7023157
https://doi.org/10.1021/bi7023157
Publikováno v:
International Journal of Peptide Research and Therapeutics. 13:31-44
Simple, effective protocols have been developed for manual and machine-assisted Boc-chemistry solid phase peptide synthesis on polystyrene resins. These use in situ neutralization [i.e. neutralization simultaneous with coupling], high concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3b5123b035cb4b859189abe27ecee8
https://doi.org/10.1007/s10989-006-9059-7
https://doi.org/10.1007/s10989-006-9059-7
Autor:
Paul F. Alewood, Peter R. Andrews, Edouard C. Nice, Teresa Domagala, Sara J. White, Julie Rothacker, Francesca Walker, Maureen Nerrie, David J. Craik, Kathy Nielsen, Antony W. Burgess, Dianne Alewood
Publikováno v:
Growth Factors. 23:97-110
A systematic study using solid phase peptide synthesis has been undertaken to examine the role of the disulfide bonds in the structure and function of mEGF. A combination of one, two and three native disulfide pair analogues of an active truncated (4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edd362a9c2972d59f03ebfddaf3f9f2
https://doi.org/10.1080/08977190500096061
https://doi.org/10.1080/08977190500096061
Autor:
Paul K. Pallaghy, Dianne Alewood, Raymond S. Norton, Paul F. Alewood, Graham M. Nicholson, Liesl C. Birinyi-Strachan
Publikováno v:
Biochemistry. 42:12933-12940
Delta-atracotoxin-Ar1a (delta-ACTX-Ar1a) is the major polypeptide neurotoxin isolated from the venom of the male Sydney funnel-web spider, Atrax robustus. This neurotoxin targets both insect and mammalian voltage-gated sodium channels, where it compe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9764f9cff2a8741f0d98fe8547f22ede
https://doi.org/10.1021/bi030091n
https://doi.org/10.1021/bi030091n
Publikováno v:
Toxicon. 40:711-719
Nuclear magnetic resonance spectroscopy was used to investigate the conformations of the platypus venom C-type natriuretic peptide A (OvCNPa) in aqueous solutions and in solutions containing sodium dodecyl sulfate (SDS) micelles. The chemically synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce141550649a5db95741dd5ea72ac1d5
https://doi.org/10.1016/s0041-0101(01)00266-5
https://doi.org/10.1016/s0041-0101(01)00266-5
Autor:
Paul F. Alewood, Arne W. Mould, Halle Morton, Judith M. Greer, Dianne Alewood, Alice C. Cavanagh, Stephen G. Love, J. Harness, Bing Zhang, Pamela A. McCombe, Narelle C. Hillyard, Maria J Somodevilla-Torres
Publikováno v:
Journal of the Neurological Sciences. 182:5-15
Early pregnancy factor (EPF) is a secreted protein with immunosuppressive and growth factor properties. During pregnancy, it appears in maternal serum within 6-24 h of fertilization, is present for at least the first two-thirds of pregnancy in all sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f30874a799ac7c360f2bee33df04b8c5
https://doi.org/10.1016/s0022-510x(00)00432-9
https://doi.org/10.1016/s0022-510x(00)00432-9
Autor:
Paul F. Alewood, David P. Tyssen, Dianne Alewood, Darren K. Jardine, Jennifer L. Martin, David P. Fairlie, Robert Reid, Douglas A. Bergman, Leonard Keith Pattenden, Margaret R. Passmore, Christopher J. Birch, Belinda Todd, Joel D. A. Tyndall, Darren R. March, Shu-Hong Hu
Publikováno v:
Journal of Medicinal Chemistry. 43:3495-3504
Three new peptidomimetics (1-3) have been developed with highly stable and conformationally constrained macrocyclic components that replace tripeptide segments of protease substrates. Each compound inhibits both HIV-1 protease and viral replication (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62fb3e594fc02553e3d05e3e3dcb8f23
https://doi.org/10.1021/jm000013n
https://doi.org/10.1021/jm000013n
Autor:
Jamie I. Fletcher, Ross Smith, Xiu-hong Wang, Richard J. Simpson, Cliff H. Gallagher, Paul F. Alewood, Philip W. Kuchel, Struan K. Sutherland, Dianne Alewood, Glenn F. King, Allan M. Torres, Graham M. Nicholson
Publikováno v:
Biochemical Journal. 341:785-794
Three defensin-like peptides (DLPs) were isolated from platypus venom and sequenced. One of these peptides, DLP-1, was synthesized chemically and its three-dimensional structure was determined using NMR spectroscopy. The main structural elements of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::811b87a35f093d288cdfb3aa416f445e
https://doi.org/10.1042/bj3410785
https://doi.org/10.1042/bj3410785