Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Diann M. McCoy"'
Publikováno v:
Journal of Lipid Research, Vol 46, Iss 6, Pp 1229-1238 (2005)
Ceramide is a key bioactive mediator that inhibits surfactant phosphatidylcholine (PtdCho) synthesis in lung epithelia. Ceramide availability is governed by sphingomyelin (SM) hydrolysis, but less is known regarding its de novo synthesis. In this stu
Externí odkaz:
https://doaj.org/article/651d410fd9154a18b6a82f3bb283b093
Lipoprotein deprivation stimulates transcription of the CTP:phosphocholine cytidylyltransferase gene
Publikováno v:
Journal of Lipid Research, Vol 41, Iss 8, Pp 1268-1277 (2000)
We examined the effect of lipoprotein deprivation on the expression of the rate-regulatory enzyme involved in phosphatidylcholine (PtdCho) synthesis, phosphocholine cytidylyltransferase (CCT), within an alveolar type II epithelial cell line (MLE-12).
Externí odkaz:
https://doaj.org/article/26bcd9afb9f241e38364d8701f2aea87
Autor:
Stephen E. McGowan, Diann M. McCoy
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 320:L179-L192
Platelet-derived growth factor receptor-α (PDGFRα) is absolutely required for the development of secondary pulmonary alveolar septa. Our earlier observations indicated that PDGFRα resides intracellularly as well as on the plasma membrane of murine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e157e6d124040f164570c827350599f3
https://doi.org/10.1152/ajplung.00149.2020
https://doi.org/10.1152/ajplung.00149.2020
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 62:454-465
During pulmonary secondary alveolar septation, the rudimentary distal saccule subdivides by extending tissue sheets into the saccular air space, creating alveoli, which open into the alveolar duct. The sheets originate from saccular mesenchymal cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cb04f027cb0783addccfd38b03ec18
https://doi.org/10.1165/rcmb.2019-0173oc
https://doi.org/10.1165/rcmb.2019-0173oc
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 315:L102-L115
Generation of secondary alveolar septa occurs primarily after birth in humans and is complete in mice postnatally, when mechanical stresses vary as air space pressure oscillates. Alveolar mesenchymal cells deposit elastic fibers, which limit cell str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5680d68cf7d067609d5e700bec42fa0e
https://doi.org/10.1152/ajplung.00511.2017
https://doi.org/10.1152/ajplung.00511.2017
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 313:L1174-L1187
Platelet-derived growth factor (PDGF)-A, which only signals through PDGF-receptor-α (PDGFR-α), is required for secondary alveolar septal formation. Although PDGFR-α distinguishes mesenchymal progenitor cells during the saccular stage, PDGFR-α-exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::899b0998f98a9d289e0fdb1abbbf416d
https://doi.org/10.1152/ajplung.00185.2017
https://doi.org/10.1152/ajplung.00185.2017
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American journal of respiratory cell and molecular biology. 57(1)
Glucocorticoids have been widely used and exert pleiotropic effects on alveolar structure and function, but do not improve the long-term clinical outcomes for patients with bronchopulmonary dysplasia, emphysema, or interstitial lung diseases. Treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20a2fe0e9492a3af0e4daab163e2ca2b
https://pubmed.ncbi.nlm.nih.gov/28530121
https://pubmed.ncbi.nlm.nih.gov/28530121
Autor:
Diann M. McCoy, Stephen E. McGowan
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 305:L229-L239
Alveolar septal formation is required to support the respiration of growing mammals; in humans effacement of the alveolar surface and impaired gas exchange are critical features of emphysema and pulmonary fibrosis. Platelet-derived growth factor-A (P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::625f8c2fdf28a556149be3fe8f3098f0
https://doi.org/10.1152/ajplung.00011.2013
https://doi.org/10.1152/ajplung.00011.2013
Autor:
Christopher A Etscheidt, Bill B. Chen, Lakshmi Durairaj, Diann M. McCoy, Emily C Hayes-Rowan, Marianna Agassandian, Satya N. Mathur, Jessica C. Sieren, Valerian E. Kagan, Nancy B. Ray, Yulia Y. Tyurina, Phillip L Butler, Florita C. Henderson, Bryan J. McVerry, Michael P. Donahoe, Alisa K. Waltenbaugh, Rama K. Mallampalli, Geoffrey McLennan, Alan J. Ryan, Lokesh Gakhar, Tiffany A. Coon, Christopher P. O'Donnell
Publikováno v:
Nature medicine
Pneumonia remains the leading cause of death from infection in the US, yet fundamentally new conceptual models underlying its pathogenesis have not emerged. We show that humans and mice with bacterial pneumonia have markedly elevated amounts of cardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6348c39a61705b54997b77b267a97892
https://doi.org/10.1038/nm.2213
https://doi.org/10.1038/nm.2213
Publikováno v:
Traffic. 8:1765-1777
Surfactant, highly enriched with phosphatidylcholine (PC), is secreted into the airspace by a classic apical secretory route, thereby maintaining lung stability. Herein, we show that adenoviral infection decreases surfactant PC in lungs by inhibiting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09733bc1a5ce4fff04e23a27c0ce2192
https://doi.org/10.1111/j.1600-0854.2007.00641.x
https://doi.org/10.1111/j.1600-0854.2007.00641.x