Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Dianhua Qiao"'
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionThe human orthopneumovirus, Respiratory Syncytial Virus (RSV), is the causative agent of severe lower respiratory tract infections (LRTI) and exacerbations of chronic lung diseases. In immune competent hosts, RSV productively infects high
Externí odkaz:
https://doaj.org/article/2ac32dbd477c4ebc93c9a44112e5308c
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionThe unfolded protein response (UPR) has emerged as an important signaling pathway mediating anti-viral defenses to Respiratory Syncytial Virus (RSV) infection. Earlier we found that RSV replication predominantly activates the evolutionari
Externí odkaz:
https://doaj.org/article/a0a13e3f30644240974949af762dcb9e
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Disruption of the lower airway epithelial barrier plays a major role in the initiation and progression of chronic lung disease. Here, repetitive environmental insults produced by viral and allergens triggers metabolic adaptations, epithelial-mesenchy
Externí odkaz:
https://doaj.org/article/d0a670dc8d69481dac122426a09afb3f
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Bromodomain-containing protein 4 plays a central role in coordinating the complex epigenetic component of the innate immune response. Previous studies implicated BRD4 as a component of a chromatin-modifying complex that is dynamically recruited to a
Externí odkaz:
https://doaj.org/article/5154f28d912b4a079eb394d8178b5e67
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 16, p 9000 (2022)
Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections (LRTI) associated with decreased pulmonary function, asthma, and allergy. Recently, we demonstrated that RSV induces the hexosamine biosynthetic pathway via the unfold
Externí odkaz:
https://doaj.org/article/47461d99f6ca458cab78480b4e70fe09
Autor:
Jichao Sun, Jared Carlson-Stevermer, Utpal Das, Minjie Shen, Marion Delenclos, Amanda M. Snead, So Yeon Koo, Lina Wang, Dianhua Qiao, Jonathan Loi, Andrew J. Petersen, Michael Stockton, Anita Bhattacharyya, Mathew V. Jones, Xinyu Zhao, Pamela J. McLean, Andrew A. Sproul, Krishanu Saha, Subhojit Roy
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Gene editing strategies are typically designed to correct mutant genes, but most neurodegenerative diseases are sporadic. Here the authors describe a strategy to selectively edit the C-terminus of APP and attenuate amyloid-β production, while upregu
Externí odkaz:
https://doaj.org/article/9b7514e64c5f429f8af27f9559663d3c
Publikováno v:
Cells, Vol 11, Iss 14, p 2210 (2022)
Respiratory syncytial virus (RSV), or human orthopneumovirus, is a negative-sense RNA virus that is the causative agent of severe lower respiratory tract infections in children and is associated with exacerbations of adult lung disease. The mechanism
Externí odkaz:
https://doaj.org/article/477def88ea9648789c323e5ce379aec1
Autor:
Xiaofang Xu, Dianhua Qiao, Chenyang Dong, Morgan Mann, Roberto P. Garofalo, Sunduz Keles, Allan R. Brasier
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Epigenetics plays an important role in the priming the dynamic response of airway epithelial cells to infectious and environmental stressors. Here, we examine the epigenetic role of the SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of
Externí odkaz:
https://doaj.org/article/a2e4937bfa6645acb514543e2cdf6f91
Publikováno v:
Viruses, Vol 13, Iss 2, p 218 (2021)
The innate immune response (IIR) involves rapid genomic expression of protective interferons (IFNs) and inflammatory cytokines triggered by intracellular viral replication. Although the transcriptional control of the innate pathway is known in substa
Externí odkaz:
https://doaj.org/article/ca97ff2bff524eeb919169abc320a8b0
Publikováno v:
Viruses, Vol 12, Iss 8, p 804 (2020)
Lower respiratory tract infection (LRTI) with respiratory syncytial virus (RSV) is associated with reduced lung function through unclear mechanisms. In this study, we test the hypothesis that RSV infection induces genomic reprogramming of extracellul
Externí odkaz:
https://doaj.org/article/c0d1e54f1ab2474fbf0cab5812375557