Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Dianfan Li"'
Autor:
Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, Dianfan Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract The secretion and quality control of glycosylphosphatidylinositol-anchored proteins (GPI-APs) necessitates post-attachment remodeling initiated by the evolutionarily conserved PGAP1, which deacylates the inositol in nascent GPI-APs. Impairme
Externí odkaz:
https://doaj.org/article/57993c1664af4119a9b95d0080a2d232
Autor:
Yidan Xu, Tingting Li, Zixuan Zhou, Jingjing Hong, Yulin Chao, Zhini Zhu, Ying Zhang, Qianhui Qu, Dianfan Li
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Many eukaryotic receptors and enzymes rely on glycosylphosphatidylinositol (GPI) anchors for membrane localization and function. The transmembrane complex GPI-T recognizes diverse proproteins at a signal peptide region that lacks consensus s
Externí odkaz:
https://doaj.org/article/d5ef8108d0014331b18593fdd3743b4d
Publikováno v:
Viruses, Vol 16, Iss 4, p 566 (2024)
Neutralizing antibodies (nAbs) play an important role against SARS-CoV-2 infections. Previously, we have reported one potent receptor binding domain (RBD)-binding nAb Ab08 against the SARS-CoV-2 prototype and a panel of variants, but Ab08 showed much
Externí odkaz:
https://doaj.org/article/78621dd9abf84992b5b45b859b47aeb9
Autor:
Shi Yu, Xu Zheng, Yanqiu Zhou, Yuhui Gao, Bingjie Zhou, Yapei Zhao, Tingting Li, Yunyi Li, Jiabin Mou, Xiaoxian Cui, Yuying Yang, Dianfan Li, Min Chen, Dimitri Lavillette, Guangxun Meng
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011789 (2023)
The COVID pandemic fueled by emerging SARS-CoV-2 new variants of concern remains a major global health concern, and the constantly emerging mutations present challenges to current therapeutics. The spike glycoprotein is not only essential for the ini
Externí odkaz:
https://doaj.org/article/95a69b5254724c368e17456771ac2be0
Autor:
Yidan Xu, Guowen Jia, Tingting Li, Zixuan Zhou, Yitian Luo, Yulin Chao, Juan Bao, Zhaoming Su, Qianhui Qu, Dianfan Li
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
GPI-T catalyzes the committed step in GPI anchor protein biogenesis. Here, Xu et al. report the cryo-EM structure of the human GPI-T, revealing critical elements within an elongated, shared active site which is topologically arranged for substrate sp
Externí odkaz:
https://doaj.org/article/adcaed8c934d4f11b08b9d290288a8e0
Autor:
Lu Meng, Jialu Zha, Bingjie Zhou, Long Cao, Congli Jiang, Yuanfei Zhu, Teng Li, Lu Lu, Junqi Zhang, Heng Yang, Jian Feng, Zhifeng Gu, Hong Tang, Lubin Jiang, Dianfan Li, Dimitri Lavillette, Xiaoming Zhang
Publikováno v:
PLoS Pathogens, Vol 19, Iss 1, p e1011085 (2023)
Neutralizing antibodies (nAbs) are important assets to fight COVID-19, but most existing nAbs lose the activities against Omicron subvariants. Here, we report a human monoclonal antibody (Ab08) isolated from a convalescent patient infected with the p
Externí odkaz:
https://doaj.org/article/c5a977acb68c43f080f6da78d448a835
Autor:
Tingting Li, Hongmin Cai, Yapei Zhao, Yanfang Li, Yanling Lai, Hebang Yao, Liu Daisy Liu, Zhou Sun, Martje Fentener van Vlissingen, Thijs Kuiken, Corine H GeurtsvanKessel, Ning Zhang, Bingjie Zhou, Lu Lu, Yuhuan Gong, Wenming Qin, Moumita Mondal, Bowen Duan, Shiqi Xu, Audrey S Richard, Hervé Raoul, JianFeng Chen, Chenqi Xu, Ligang Wu, Haisheng Zhou, Zhong Huang, Xuechao Zhang, Jun Li, Yanyan Wang, Yuhai Bi, Barry Rockx, Junfang Chen, Fei‐Long Meng, Dimitri Lavillette, Dianfan Li
Publikováno v:
EMBO Molecular Medicine, Vol 13, Iss 12, Pp 1-21 (2021)
Abstract An essential step for SARS‐CoV‐2 infection is the attachment to the host cell receptor by its Spike receptor‐binding domain (RBD). Most of the existing RBD‐targeting neutralizing antibodies block the receptor‐binding motif (RBM), a
Externí odkaz:
https://doaj.org/article/7f206b05d79247f4a77f570a14981163
Autor:
Tingting Li, Hongmin Cai, Hebang Yao, Bingjie Zhou, Ning Zhang, Martje Fentener van Vlissingen, Thijs Kuiken, Wenyu Han, Corine H. GeurtsvanKessel, Yuhuan Gong, Yapei Zhao, Quan Shen, Wenming Qin, Xiao-Xu Tian, Chao Peng, Yanling Lai, Yanxing Wang, Cedric A. J. Hutter, Shu-Ming Kuo, Juan Bao, Caixuan Liu, Yifan Wang, Audrey S. Richard, Hervé Raoul, Jiaming Lan, Markus A. Seeger, Yao Cong, Barry Rockx, Gary Wong, Yuhai Bi, Dimitri Lavillette, Dianfan Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors report the engineering, structural and biological characterization of synthetic nanobodies (sybodies) that display potent therapeutic activity against SARS-CoV-2 infection in animal models via targeting the virus receptor-binding do
Externí odkaz:
https://doaj.org/article/e2d2ef9db7c042d5ae0d4a35e2484adb
Autor:
Tingting Li, Bingjie Zhou, Zhipu Luo, Yanling Lai, Suqiong Huang, Yuanze Zhou, Yaning Li, Anupriya Gautam, Salome Bourgeau, Shurui Wang, Juan Bao, Jingquan Tan, Dimitri Lavillette, Dianfan Li
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
SARS-CoV-2 and its variants, such as the Omicron continue to threaten public health. The virus recognizes the host cell by attaching its Spike (S) receptor-binding domain (RBD) to the host receptor, ACE2. Therefore, RBD is a primary target for neutra
Externí odkaz:
https://doaj.org/article/388b71d2aef845efbeb6a98de15c8137
Publikováno v:
Current Research in Structural Biology, Vol 3, Iss , Pp 312-323 (2021)
Phosphatidylglycerol is a crucial phospholipid found ubiquitously in biological membranes of prokaryotic and eukaryotic cells. The phosphatidylglycerol phosphate (PGP) synthase (PgsA), a membrane-embedded enzyme, catalyzes the primary reaction of pho
Externí odkaz:
https://doaj.org/article/0ff6ec97c388461588eb84a09f42d98c