Safety and immunogenicity of a trivalent virus-like particle vaccine against western, eastern, and Venezuelan equine encephalitis viruses: a phase 1, open-label, dose-escalation, randomised clinical trial

Autor: Emily E Coates, Srilatha Edupuganti, Grace L Chen, Myra Happe, Larisa Strom, Alicia Widge, Maria Burgos Florez, Josephine H Cox, Ingelise Gordon, Sarah Plummer, Abidemi Ola, Galina Yamshchikov, Charla Andrews, Sharon Curate-Ingram, Patricia Morgan, Shashi Nagar, Matthew H Collins, Amy Bray, Thuy Nguyen, Judy Stein, Christopher L Case, Florence Kaltovich, Diane Wycuff, C Jason Liang, Kevin Carlton, Sandra Vazquez, John R Mascola, Julie E Ledgerwood, Ellie Butler, Jean Winter, Jianguo Xu, Amy Sherman, Colleen Kelley, Rameses Fredrick, Nadine Rouphael, Varun Phadke, Cynthia Whitney, Alicarmen Alvarez, Renata Dennis, Rebecca Fineman, Pamela Lankford-Turner, Sha Yi, Lilin Lai, Gena Burch, Shanker Gupta, Nina Berkowitz, Cristina Carter, Allison Beck, Brenda Larkin, Stephanie Taylor, Mandy Alger, Jessica Bahorich, Amy Lynch Chamberlain, Ya-chen Chang, Rajoshi Chaudhuri, Jonathan Cooper, Jacob Demirji, Fan Yang, Alissa Fernald, Deepika Gollapudi, Janel Holland-Linn, Lisa Kueltzo, James Lee, Jie Liu, Xun Liu, Rachel Mowery, Sarah O'Connell, Erwin Rosales-Zavala, Jason Sands, Xin Wang, Shaojie Weng, Sara Witter

Publikováno v: The Lancet. Infectious diseases. 22(8)

Western (WEEV), eastern (EEEV), and Venezuelan (VEEV) equine encephalitis viruses are mosquito-borne pathogens classified as potential biological warfare agents for which there are currently no approved human vaccines or therapies. We aimed to evalua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08a0d3beda287fd4279f1fb3783a3465
https://pubmed.ncbi.nlm.nih.gov/35568050

Development of high‐throughput and high sensitivity capillary gel electrophoresis platform method for Western, Eastern, and Venezuelan equine encephalitis (WEVEE) virus like particles (VLPs) purity determination and characterization

Autor: Jonathan W. Cooper, K. C. Cheng, Deepika Gollapudi, Diane Wycuff, Richard M. Schwartz

Publikováno v: ELECTROPHORESIS. 38:2610-2621

In this paper, we describe development of a high-throughput, highly sensitive method based on Lab Chip CGE-SDS platform for purity determination and characterization of virus-like particle (VLP) vaccines. A capillary gel electrophoresis approach requ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::085010c369952041614e168b66e28612
https://doi.org/10.1002/elps.201700217

Antibody Specificities Associated with Neutralization Breadth in Plasma from Human Immunodeficiency Virus Type 1 Subtype C-Infected Blood Donors

Autor: John R. Mascola, Natasha Taylor, George M. Shaw, Blake Wood, Elin S. Gray, Allan C. deCamp, Diane Wycuff, Adrian Puren, David C. Montefiori, Georgia D. Tomaras, Lynn Morris, James M. Binley, Penny L. Moore, Peter B. Gilbert, Constantinos Kurt Wibmer, Barton F. Haynes

Publikováno v: Journal of Virology. 83:8925-8937

Defining the specificities of the anti-human immunodeficiency virus type 1 (HIV-1) envelope antibodies able to mediate broad heterologous neutralization will assist in identifying targets for an HIV-1 vaccine. We screened 70 plasmas from chronically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07b7fc12cbd4abafd2e0de36e33f8f2b
https://doi.org/10.1128/jvi.00758-09

Profiling the Specificity of Neutralizing Antibodies in a Large Panel of Plasmas from Patients Chronically Infected with Human Immunodeficiency Virus Type 1 Subtypes B and C

Autor: John R. Mascola, James E. Robinson, Lynn Morris, Cory Nathe, Elizabeth A. Lybarger, Diane Wycuff, Douglas D. Richman, Emma T. Crooks, Frederic Bibollet-Ruche, James M. Binley, Blake Wood, Linda Harris, Elin S. Gray, David C. Montefiori, Natalie Hawkins, George M. Shaw, Julie M. Decker, Georgia D. Tomaras, Katie L. Davis, Michael S. Seaman

Publikováno v: Journal of Virology. 82:11651-11668

Identifying the viral epitopes targeted by broad neutralizing antibodies (NAbs) that sometimes develop in human immunodeficiency virus type 1 (HIV-1)-infected subjects should assist in the design of vaccines to elicit similar responses. Here, we inve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b79556501d4bb3e81592ff690021293
https://doi.org/10.1128/jvi.01762-08

126 Broadly Neutralizing HIV Abs

Autor: Peter D. Kwong, John R. Mascola, Ling Xu, Michael S. Seaman, Yi Feng, Stephen D. Schmidt, Zhi Yong Yang, Mark Connors, Nicole A. Doria-Rose, Mario Roederer, Krisha McKee, Gary J. Nabel, Yuxing Li, Diane Wycuff, Martha Nason, Mark K. Louder, Carl-Magnus Hogerkorp, Xueling Wu, William R. Schief, Sijy Oʼdell, Nancy S. Longo, Lan Wu, Tongqing Zhou

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 59:52

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9cd95fd32d8130547951c384fa272ea4
https://doi.org/10.1097/01.qai.0000413745.31643.03