Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Diane Wilcock"'
Autor:
John A Corbin, Vinay Bhaskar, Ira D Goldfine, Daniel H Bedinger, Angela Lau, Kristen Michelson, Lisa M Gross, Betty A Maddux, Hua F Kuan, Catarina Tran, Llewelyn Lao, Masahisa Handa, Susan R Watson, Ajay J Narasimha, Shirley Zhu, Raphael Levy, Lynn Webster, Sujeewa D Wijesuriya, Naichi Liu, Xiaorong Wu, David Chemla-Vogel, Steve R Lee, Steve Wong, Diane Wilcock, Mark L White
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88684 (2014)
Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human
Externí odkaz:
https://doaj.org/article/ec07dde7e6df4a3f9009b736ea547f18
Autor:
Shirley Zhu, David Chemla-Vogel, Ajay J. Narasimha, Lynn Webster, Angela Lau, Sujeewa D. Wijesuriya, Diane Wilcock, Raphael Levy, Hassan Issafras, Paul Rubin, Hua F. Kuan, Catarina Tran, Daniel Bedinger, Vinay Bhaskar, Ira D. Goldfine, John Corbin, Xiaorong Wu, Susan R. Watson, Llewelyn Lao, Naichi Liu, Kristen Michelson, Masahisa Handa, Lisa Gross, Steve R. Lee, Steve Wong, Betty A. Maddux, Mark L. White
Publikováno v:
mAbs
Novel therapies are needed for the treatment of hypoglycemia resulting from both endogenous and exogenous hyperinsulinema. To provide a potential new treatment option, we identified XMetD, an allosteric monoclonal antibody to the insulin receptor (IN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a981aef464820bb0d1ce04c389f12b84
https://doi.org/10.4161/mabs.26871
https://doi.org/10.4161/mabs.26871
Autor:
Masahisa Handa, Diane Wilcock, Ajay J. Narasimha, Raphael Levy, Lynn Webster, Sujeewa D. Wijesuriya, John Corbin, Steve R. Lee, Hua F. Kuan, Daniel Bedinger, Xiaorong Wu, Vinay Bhaskar, Shirley Zhu, David Chemla-Vogel, Lisa Gross, Steve Wong, Mark L. White, Susan R. Watson, Naichi Liu, Catarina Tran, Ira D. Goldfine, Angela Lau, Betty A. Maddux
Publikováno v:
Diabetes
Many patients with diabetes mellitus (both type 1 and type 2) require therapy to maintain normal fasting glucose levels. To develop a novel treatment for these individuals, we used phage display technology to target the insulin receptor (INSR) comple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de204c14d0a31a17006c9725a778704b
http://europepmc.org/articles/PMC3331746
http://europepmc.org/articles/PMC3331746
Publikováno v:
Journal of Virology. 74:11654-11662
Vaccinia virus gene F12L is shown to encode a 65-kDa protein that is synthesized early and late during infection and that is not modified by glycosylation. Computational sequence comparison revealed that related proteins are encoded by all sequenced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462227e70ac3a31141f4158e4bcfa3b6
https://doi.org/10.1128/jvi.74.24.11654-11662.2000
https://doi.org/10.1128/jvi.74.24.11654-11662.2000
Publikováno v:
Journal of General Virology. 80:2137-2148
Gene A40R from vaccinia virus (VV) strain Western Reserve has been characterized. The open reading frame (ORF) was predicted to encode a 159 amino acid, 18152 Da protein with amino acid similarity to C-type animal lectins and to the VV A34R protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53cdf03b7b540b8db4fdbc7fc8094187
https://doi.org/10.1099/0022-1317-80-8-2137
https://doi.org/10.1099/0022-1317-80-8-2137
Publikováno v:
Journal of General Virology. 77:2827-2831
Four DNA-dependent ATPases were purified from vaccinia virions and tested for DNA helicase activity on two dsDNA substrates. ATPases D6R and D11L were inactive on both substrates, A18R unwound the substrate with a short 20 bp duplex region and 18R un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bffb63675e31f3d7d81e2ee62df9c44a
https://doi.org/10.1099/0022-1317-77-11-2827
https://doi.org/10.1099/0022-1317-77-11-2827
Autor:
Sujeewa D. Wijesuriya, Ajay J. Narasimha, Xiaorong Wu, Lynn Webster, Lisa Gross, Catarina Tran, Daniel Bedinger, Hua F. Kuan, Steve Wong, Susan R. Watson, Kristen Michelson, Betty A. Maddux, John Corbin, Masahisa Handa, Shirley Zhu, Angela Lau, Llewelyn Lao, Naichi Liu, Ira D. Goldfine, Mark L. White, Steve R. Lee, Diane Wilcock, Vinay Bhaskar, Raphaël Lévy, David Chemla-Vogel
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88684 (2014)
PLoS ONE
PLoS ONE
Previously we reported studies of XMetA, an agonist antibody to the insulin receptor (INSR). We have now utilized phage display to identify XMetS, a novel monoclonal antibody to the INSR. Biophysical studies demonstrated that XMetS bound to the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64576dbe1d46057140b004ce590d1e4b
https://doi.org/10.1371/journal.pone.0088684
https://doi.org/10.1371/journal.pone.0088684
Autor:
Diane Wilcock, David P. Lane
Publikováno v:
Nature. 349:429-431
Replication of DNA occurs at discrete sites in eukaryotic cell nuclei, where replication proteins are clustered into large complexes, or 'replicases'. Similarly, viral DNA replication is a highly structured process, notably in herpes simplex virus ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c28829e2771bed2c831fb98f68de2ae7
https://doi.org/10.1038/349429a0
https://doi.org/10.1038/349429a0
Publikováno v:
The Journal of general virology. 80
Gene A40R from vaccinia virus (VV) strain Western Reserve has been characterized. The open reading frame (ORF) was predicted to encode a 159 amino acid, 18152 Da protein with amino acid similarity to C-type animal lectins and to the VV A34R protein,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::faa5a28d8270fc228ca5983a50a9252e
https://pubmed.ncbi.nlm.nih.gov/10466813
https://pubmed.ncbi.nlm.nih.gov/10466813
Autor:
Geoffrey L. Smith, Diane Wilcock
Publikováno v:
Virology. 202(1)
A recombinant vaccinia virus, vDW4, has been constructed in which the L4R gene encoding the VP8 core DNA-binding protein is inducibly regulated by IPTG (isopropyl beta-D-thiogalactopyranoside). This virus produced normal-sized plaques in the presence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84a904a2cb803e71f7160706b456fab
https://pubmed.ncbi.nlm.nih.gov/8009841
https://pubmed.ncbi.nlm.nih.gov/8009841