Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Diane V Lefley"'
Autor:
Mai Morita, Fawaz Arshad, Lewis A. Quayle, Christopher N. George, Diane V. Lefley, Ivo Kalajzic, Meena Balsubramanian, Tugba Cebe, Gwen Reilly, Nicolas J. Bishop, Penelope D. Ottewell
Publikováno v:
Bone Reports, Vol 22, Iss , Pp 101795- (2024)
Excessive production of Transforming Growth Factor β (TGFβ) is commonly associated with dominant and recessive forms of OI. Previous reports have indicated that administration of TGFβ-targeted antibodies maybe of potential therapeutic benefit to O
Externí odkaz:
https://doaj.org/article/a7a0cce7a6dc4695a9b672b575366fde
Autor:
Claudia Tulotta, Diane V. Lefley, Charlotte K. Moore, Ana E. Amariutei, Amy R. Spicer-Hadlington, Lewis A. Quayle, Russell O. Hughes, Khawla Ahmed, Victoria Cookson, Catherine A. Evans, Jayakumar Vadakekolathu, Paul Heath, Sheila Francis, Emmanuel Pinteaux, A. Graham Pockley, Penelope D. Ottewell
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)
Abstract Breast cancer bone metastasis is currently incurable, ~75% of patients with late-stage breast cancer develop disease recurrence in bone and available treatments are only palliative. We have previously shown that production of the pro-inflamm
Externí odkaz:
https://doaj.org/article/db7c85c82ea947e69d237a3402f52c96
Autor:
Victor G. Canuas-Landero, Christopher N. George, Diane V. Lefley, Hannah Corness, Munitta Muthana, Caroline Wilson, Penelope D. Ottewell
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Clinical trials have demonstrated that adding zoledronic acid (Zol) to (neo)adjuvant standard of care has differential antitumour effects in pre- and post-menopausal women: Both benefit from reduced recurrence in bone; however, while postmenopausal w
Externí odkaz:
https://doaj.org/article/bacfe60dab50449a89369bedf253a759
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
Summary of the effects of IL-1B on breast cancer progression to metastasis and growth in the bone microenvironment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c966886aa3515add73124f35ba96fdd4
https://doi.org/10.1158/1078-0432.22472744.v1
https://doi.org/10.1158/1078-0432.22472744.v1
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
Suppression of IL-1 signalling affects bone integrity and vasculature.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c325261461851db8ab242f40b164f0c7
https://doi.org/10.1158/1078-0432.22472750.v1
https://doi.org/10.1158/1078-0432.22472750.v1
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
Supplementary figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c44d71f01e6bbe78530a36fc9eede0dc
https://doi.org/10.1158/1078-0432.22472741.v1
https://doi.org/10.1158/1078-0432.22472741.v1
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
Effects of IL-1B on osteoclast and osteoblast activity in vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::517b007b54acb30669ee466909235f57
https://doi.org/10.1158/1078-0432.22472747.v1
https://doi.org/10.1158/1078-0432.22472747.v1
Autor:
Gillian M. Tozer, Chryso Kanthou, Scott K. Lyons, Jack E. Hurrell, Karina Bingham, Yu-Chin Lee, Mohit Dhingra, Diane V. Lefley, Matthew Fisher, Sarah Jane Lunt, William R. English
Elevated plasma concentrations of soluble VEGFA isoforms are associated with poor prognosis in parallel with improved response to treatment with the anti-VEGFA antibody bevacizumab. To uncover the underlying mechanism to these observations, we admini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7aaba787cfa8fbaa921a7be20ca3fdb1
https://doi.org/10.1158/0008-5472.c.6508532.v1
https://doi.org/10.1158/0008-5472.c.6508532.v1
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
Incubation with high concentrations of exogenous IL-1B modestly increases tumour cell migration and invasion.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53ba561472369534842ef8e89064113d
https://doi.org/10.1158/1078-0432.22472756.v1
https://doi.org/10.1158/1078-0432.22472756.v1
Autor:
Penelope D. Ottewell, Ingunn Holen, Janet E. Brown, Robert E. Coleman, Marianna Kruithof de Julio, Gloria Allocca, Victoria Cookson, Lisa Hambley, Steven M.J. Bradbury, Xinming Liu, Amy R. Spicer-Hadlington, J. Mark Wilkinson, Faith Nutter, Paul R. Heath, Andrew M. Hanby, Walter M. Gregory, Katy Freeman, Diane V. Lefley, Claudia Tulotta
In vivo model of spontaneous human breast cancer metastasis to human bone implants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6e4ee90c1febd67029eac311f790e5
https://doi.org/10.1158/1078-0432.22472765.v1
https://doi.org/10.1158/1078-0432.22472765.v1