Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Diane T. Stephenson"'
Autor:
Ariana P. Mullin, Diane Corey, Emily C. Turner, Richard Liwski, Daniel Olson, Jackson Burton, Sudhir Sivakumaran, Lynn D. Hudson, Klaus Romero, Diane T. Stephenson, Jane Larkindale
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 214-221 (2021)
Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history
Externí odkaz:
https://doaj.org/article/040f5d647bf1412f9332d9664f2c5e5e
Autor:
Diane T. Stephenson, Qiu Li, Carol Simmons, Mark A. Connell, Martin D. Meglasson, Kalpana Merchant, Marina E. Emborg
Publikováno v:
Neurobiology of Disease, Vol 20, Iss 2, Pp 347-359 (2005)
This study investigated the consequences of levodopa treatment on the expression of the 65- and 67-kDa isoforms of glutamate decarboxylase (GAD65 and GAD67) immunoreactivity in the basal ganglia and cortex of monkeys rendered Parkinsonian by systemic
Externí odkaz:
https://doaj.org/article/877b6d8a47e947859789cd84540e179c
Publikováno v:
Neurobiology of Disease, Vol 3, Iss 1, Pp 51-63 (1996)
Phospholipase A2(PLA2) is the key enzyme that initiates the arachidonic acid cascade, which leads to the generation of multiple eicosanoid products. Many of these products are believed to play an important role in the inflammatory process. Activation
Externí odkaz:
https://doaj.org/article/f1cfe4f1f42e4c36ae1cb2cc90259a82
Autor:
Diane T. Stephenson Ph.D., Mary Abigail Childs, Qiu Li, Santos Carvajal-Gonzalez, Alan Opsahl, Mark Tengowski, Martin D. Meglasson, Kalpana Merchant, Marina E. Emborg
Publikováno v:
Cell Transplantation, Vol 16 (2007)
Assessment of dopamine nerve terminal function and integrity is a strategy employed to monitor deficits in Parkinson's disease (PD) patients and in preclinical models of PD. Dopamine replacement therapies effectively replenish the diminished supply o
Externí odkaz:
https://doaj.org/article/f78f22b45de944e4b48ed6bb5ba91ceb
Autor:
Daniela J, Conrado, Timothy, Nicholas, Kuenhi, Tsai, Sreeraj, Macha, Vikram, Sinha, Julie, Stone, Brian, Corrigan, Massimo, Bani, Pierandrea, Muglia, Ian A, Watson, Volker D, Kern, Elena, Sheveleva, Kenneth, Marek, Diane T, Stephenson, Klaus, Romero
Publikováno v:
Clinical and Translational Science
Given the recognition that disease‐modifying therapies should focus on earlier Parkinson's disease stages, trial enrollment based purely on clinical criteria poses significant challenges. The goal herein was to determine the utility of dopamine tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fd1f281a1d3e3d73c43b4bc846b2b44
https://pubmed.ncbi.nlm.nih.gov/28749580
https://pubmed.ncbi.nlm.nih.gov/28749580
Autor:
James A. Clemens, Steven M. Paul, Jill Ann Panetta, Xiaodong Liu, Tinggui Yin, Yansheng Du, Diane T. Stephenson, Edward M. Johnstone, Sheila P. Little
Publikováno v:
Journal of Biological Chemistry. 274:28674-28681
Global brain ischemia causes cell death in the CA1 region of the hippocampus 3-5 days after reperfusion. The biological pathway leading to such delayed neuronal damage has not been established. By using differential display analysis, we examined expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b34f00d7449292f2afd281bf415c928
https://doi.org/10.1074/jbc.274.40.28674
https://doi.org/10.1074/jbc.274.40.28674
Autor:
Barry Smalstig, Jill Ann Panetta, Diane T. Stephenson, John D. Sharp, Edward M. Johnstone, James A. Clemens, Ruth M. Kramer, Edda F. Roberts, Karen S. Rash, Sheila P. Little
Publikováno v:
Glia. 27:110-128
Many recent studies have emphasized the deleterious role of inflammation in CNS injury. Increases in free fatty acids, eicosanoids, and products of lipid peroxidation are known to occur in various conditions of acute and chronic CNS injury, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::696b0ecdd6505fcc852ab9442a6f75bb
https://doi.org/10.1002/(sici)1098-1136(199908)27:2<110::aid-glia2>3.0.co
https://doi.org/10.1002/(sici)1098-1136(199908)27:2<110::aid-glia2>3.0.co
Autor:
Diane T. Stephenson, James A. Clemens
Publikováno v:
Neurochemistry International. 33:83-93
Stimulation of metabotropic glutamate receptors in vitro has been shown to accelerate the breakdown of amyloid precursor protein (APP) to form increased production of non-amyloidogenic secreted APP (sAPP). The mechanism whereby this occurs is not ent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fb37da3dfb546b35e97c6548a39348b
https://doi.org/10.1016/s0197-0186(05)80012-9
https://doi.org/10.1016/s0197-0186(05)80012-9
Publikováno v:
Stroke. 28:1073-1081
Background and Purpose After global ischemia, brain levels of hydrogen peroxide, oxygen radicals, and the cytokines tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) are increased. Oxygen radicals, TNF-α, and IL-1β are known to activat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f80cff46bc6a6ef8fc2a5831faf6d1e2
https://doi.org/10.1161/01.str.28.5.1073
https://doi.org/10.1161/01.str.28.5.1073
Autor:
E. Barry Smalstig, Kimberly S. Fuson, Patrick C. May, James A. Clemens, Diane T. Stephenson, Jill Ann Panetta
Publikováno v:
Molecular Brain Research. 42:145-148
Sulfated glycoprotein-2 (SGP-2) is a secreted glycoprotein that along with GFAP has emerged as a prominent molecular marker of neurodegeneration. In the present study, we have evaluated further the relationship between SGP-2, GFAP and neurodegenerati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b51baa43b54a07734cb6cdb3cc37961
https://doi.org/10.1016/s0169-328x(96)00155-6
https://doi.org/10.1016/s0169-328x(96)00155-6