Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Diane Savaria"'
Autor:
Diane Savaria, Alain Boudreault, Claude Lazure, Nabil G. Seidah, Normand Rondeau, Michel Chrétien, Dany Gauthier
Publikováno v:
Protein Expression and Purification. 14:353-366
A cDNA coding for the murine proprotein convertase-1 (mPC1 also known as mPC3 or mSPC3) was inserted into the Autographa californica nuclear polyhedrosis virus. Following infection of Spodoptera frugiperda cells, the recombinant N-glycosylated protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::286d68a0a0c8062e233302e5b5a98989
https://doi.org/10.1006/prep.1998.0964
https://doi.org/10.1006/prep.1998.0964
Publikováno v:
Molecular Brain Research. 59:229-246
Injury of peripheral nerves induces expression of several pro-protein convertases (PCs) involved in processing of precursor proteins into their diverse active end-products. In this study, the focus was on convertase PC1 which, although undetectable i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fdb7e40b6b1dfdb694b6ddd4b45f34
https://doi.org/10.1016/s0169-328x(98)00141-7
https://doi.org/10.1016/s0169-328x(98)00141-7
Autor:
Jacynthe Laliberté, Claude Lazure, Sangeeta Pareek, Diane Savaria, Richard A. Murphy, Michel Chrétien, Suzanne Benjannet, Nabil G. Seidah, Brigitte Goulet, Josée Hamelin
Publikováno v:
ResearcherID
In order to define the enzymes responsible for the maturation of the precursor of nerve growth factor (proNGF), its biosynthesis and intracellular processing by the pro-protein convertases furin, PC1, PC2, PACE4, PC5 and the PC5 isoform PC5/6-B were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::232247f8a0f5982cee404ea59ff4e448
https://doi.org/10.1042/bj3140951
https://doi.org/10.1042/bj3140951
Publikováno v:
Journal of Insect Physiology. 40:273-282
Ion channels in the UCR-SE-1a cell line from the beet armyworm ( Spodoptera exigua ) were studied using the patch-clamp technique in the cell-attached, the inside-out and the outside-out configurations. Contrarily to SF-9 cells from the fall armyworm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41af827c875a40696412f07ccc6702a6
https://doi.org/10.1016/0022-1910(94)90067-1
https://doi.org/10.1016/0022-1910(94)90067-1
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 70:394-402
Sarcoplasmic reticulum (SR) vesicles, prepared from rabbit skeletal muscle, were characterized by functional and binding assays and incorporated into planar lipid bilayers. Single-channel activity was recorded in an asymmetric calcium buffer system a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1000c953134844a34e160ca03b5b6b76
https://doi.org/10.1139/y92-049
https://doi.org/10.1139/y92-049
Publikováno v:
DNA and cell biology. 17(12)
The 7B2 protein is widely distributed in neural and endocrine tissues. Its biological function was found to be related to the processing enzyme proprotein convertase 2 (PC2), a mammalian subtilisin/kexin-like endoproteinase that cleaves at specific s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::729af2ef5b285acbf62f7dcd0097e1e9
https://pubmed.ncbi.nlm.nih.gov/9881669
https://pubmed.ncbi.nlm.nih.gov/9881669
Autor:
Diane Savaria, Andrea Laslop, Suzanne Benjannet, Mieczyslaw Marcinkiewicz, Michel Chrétien, Jon Scott Munzer, Nabil G. Seidah
Publikováno v:
The Journal of biological chemistry. 272(42)
We studied the extent of cellular inhibitory activity of alpha1-antitrypsin Portland (alpha1-PDX), a potent inhibitor of proprotein convertases of the subtilisin/kexin type. We compared the inhibitory effects of alpha1-PDX on the intracellular proces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bf036320e36fbbd5fdbedd50bdfc263
https://pubmed.ncbi.nlm.nih.gov/9334189
https://pubmed.ncbi.nlm.nih.gov/9334189
Autor:
Nabil G. Seidah, Josée Hamelin, Juliette Lusson, Michel Chrétien, Suzanne Benjannet, Diane Savaria
Publikováno v:
ResearcherID
In order to define the functional importance of the conserved RRGDL motif in the P-domain of the mammalian proprotein convertases (PCs) we generated and cellularly expressed three mutant PC1 vaccinia-virus (VV) recombinants: ARGDL-PC1, RAGDL-PC1 and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24a07bd80cec2f509a9d0a1bca0a0edb
https://europepmc.org/articles/PMC1218728/
https://europepmc.org/articles/PMC1218728/
Publikováno v:
Journal of neurochemistry. 64(5)
Biosynthetic pulse-chase analyses have previously demonstrated that the prohormone convertase PC2 is first synthesized as a precursor pro-PC2 and that zymogen activation to PC2 occurs following the slow exit of pro-PC2 from the endoplasmic reticulum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a0a1738f7ce253fec8a57f0e434351
https://pubmed.ncbi.nlm.nih.gov/7722516
https://pubmed.ncbi.nlm.nih.gov/7722516
Publikováno v:
FEBS letters. 362(2)
Site directed mutagenesis of the prohormone convertase PC2 was used to define the effect of certain residues on the zymogen activation of proPC2 and on its binding to the neuroendocrine protein 7B2. These included the oxyanion hole Asp309 (D309N), th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c97d92812881a5f2abda3f004224308
https://pubmed.ncbi.nlm.nih.gov/7720862
https://pubmed.ncbi.nlm.nih.gov/7720862