Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Diane S. Keeney"'
Publikováno v:
Cancer letters
The ability of chemo-radiation therapy to control locally advanced stage III non-small cell lung cancer (NSCLC) is poor. While addition of consolidation immunotherapy has improved outcomes in subsets of patients there is still an urgent need for new
Autor:
Richard Maganga, Katharine F. Adcroft, Diane S. Keeney, Natalie Giles, Arunasalam Dharmarajan, Fiona M. Wood, Mark W. Fear, Ambili Unni
Publikováno v:
Biochemical and Biophysical Research Communications. 377:606-611
The skin provides vital protection from infection and dehydration. Maintenance of the skin is through a constant program of proliferation, differentiation and apoptosis of epidermal cells, whereby proliferating cells in the basal layer differentiatin
Inflammation resolved by retinoid X receptor‐mediated inactivation of leukotriene signaling pathways
Autor:
Henry W. Strobel, Madeleine Duvic, Ying Wang, Liping Du, Auinash Kalsotra, Patricia A. Ladd, Alan S. Boyd, Yasushi Kikuta, Diane S. Keeney
Publikováno v:
The FASEB Journal. 22:538-547
Leukotrienes are implicated in the pathogenesis of diverse, inflammation-driven diseases. Metabolic inactivation of leukotriene signaling is an innate response to resolve inflammation, yet little is known of mechanisms regulating disposition of leuko
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 319:1162-1171
Human epidermal keratinocytes express subsets of cytochromes P450 (P450) (CYP gene products) that are strongly up-regulated, not regulated, or down-regulated by differentiation-specific factors. We investigated how drug exposure affects epidermal exp
Publikováno v:
Toxicology and Applied Pharmacology. 213:135-144
Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H., Mernaugh, R., Keeney, D.S., 2003. Epoxyeicosatrienoic acids activate transglutaminases in
Autor:
Setti G. Jagadeesh, John R. Falck, Liping Du, David L. Hachey, Valery Yermalitsky, Diane S. Keeney
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 316:371-379
The epidermis expresses cyclooxygenases, lipoxygenases, and cytochromes P450, which utilize arachidonic acid to generate a diverse array of lipid mediators affecting epidermal cellular differentiation and functions. Recent studies show that mouse epi
Publikováno v:
Toxicology and Applied Pharmacology. 195:278-287
Skin is the largest and most accessible drug-metabolizing organ. In mammals, it is the competent barrier that protects against exposure to harmful stimuli in the environment and in the systemic circulation. Skin expresses many cytochromes P450 that h
Autor:
Nancy J. Olsen, Fadi Adas, Mark A. Magnuson, Diane S. Keeney, Matthew D. Breyer, Michael R. Waterman, John R. Falck, Vijaykumar R. Holla, William J. Kovacs, Xueying Zhao, Edward Price, Jorge H. Capdevila, John D. Imig
Publikováno v:
Proceedings of the National Academy of Sciences. 98:5211-5216
Hypertension is a leading cause of cardiovascular, cerebral, and renal disease morbidity and mortality. Here we show that disruption of the Cyp 4a14 gene causes hypertension, which is, like most human hypertension, more severe in males. Male Cyp 4a14
Autor:
Michael R. Waterman, Diane S. Keeney
Publikováno v:
Developmental Dynamics. 216:511-517
While all cells in eukaryotic organisms probably express the gene encoding NADPH cytochrome P450 reductase, we identified two novel sites which have the highest local concentrations of P450 reductase transcripts during murine embryogenesis. One site
Publikováno v:
Journal of Biological Chemistry. 273:9279-9284
The CYP monooxygenase, CYP2B12, is the first identified skin-specific cytochrome P450 enzyme. It is characterized by high, constitutive expression in an extrahepatic tissue, the sebaceous glands of cutaneous tissues. It is expressed exclusively in a