Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Autor: Janine L. Kwapis, Yasaman Alaghband, Enikö A. Kramár, Alberto J. López, Annie Vogel Ciernia, André O. White, Guanhua Shu, Diane Rhee, Christina M. Michael, Emilie Montellier, Yu Liu, Christophe N. Magnan, Siwei Chen, Paolo Sassone-Corsi, Pierre Baldi, Dina P. Matheos, Marcelo A. Wood

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Circadian rhythms are known to modulate memory, but it’s not known whether clock genes in the hippocampus are required for memory consolidation. Here, the authors show that epigenetic regulation of clock gene Period1 in the hippocampus regulates me

Externí odkaz: https://doaj.org/article/8214879eac4444f79329a0009fdad2ee

Rewarded maze training increases approach behavior in rats through neurogenesis-dependent growth of ventral hippocampus-prelimbic circuits

Autor: Timothy J. Schoenfeld, Diane Rhee, Jesse A. Smith, Varun Padmanaban, Adam T. Brockett, Hannah Jacobs, Heather A. Cameron

Publikováno v: Biological Psychiatry Global Open Science.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b58c882c0a9084d5800345e870625943
https://doi.org/10.1016/j.bpsgos.2023.04.003

Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory

Autor: Alberto J. López, Siwei Chen, Guanhua Shu, Diane Rhee, André O. White, Christophe Magnan, Dina P. Matheos, Marcelo A. Wood, Annie Vogel Ciernia, Paolo Sassone-Corsi, Yasaman Alaghband, Emilie Montellier, Janine L. Kwapis, Yu Liu, Christina M. Michael, Enikö A. Kramár, Pierre Baldi

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Nature Communications
Kwapis, JL; Alaghband, Y; Kramár, EA; López, AJ; Vogel Ciernia, A; White, AO; et al.(2018). Epigenetic regulation of the circadian gene Per1 contributes to age-related changes in hippocampal memory. Nature Communications, 9(1). doi: 10.1038/s41467-018-05868-0. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/6mq1q71w

Aging is accompanied by impairments in both circadian rhythmicity and long-term memory. Although it is clear that memory performance is affected by circadian cycling, it is unknown whether age-related disruption of the circadian clock causes impaired

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284932e20b6cbfb7f16e1835563b42d5
http://link.springer.com/article/10.1038/s41467-018-05868-0

Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala

Autor: Janine L. Kwapis, Diane Rhee, André O. White, Richard Dang, Allison E Carl, Marcelo A. Wood, Alberto J. López, Rianne R. Campbell, Yasaman Alaghband, Dina P. Matheos, Ashley Tran

Publikováno v: Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, vol 42, iss 6

Histone acetylation is a fundamental epigenetic mechanism that is dynamically regulated during memory formation. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) compete to modulate histone acetylation, allowing for rapid changes in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5c60e6bf39abf1fc1f7d50240c0f4e
https://doi.org/10.1038/npp.2016.274

New neurons restore structural and behavioral abnormalities in a rat model of PTSD

Autor: Diane Rhee, Jesse A. Smith, Heather A. Cameron, Varun Padmanaban, Anup N. Sonti, Timothy J. Schoenfeld, Laura B. Martin

Publikováno v: Hippocampus. 29(9)

Post-traumatic stress disorder (PTSD) has been associated with anxiety, memory impairments, enhanced fear, and hippocampal volume loss, although the relationship between these changes remain unknown. Single-prolonged stress (SPS) is a model for PTSD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::920a387115db30bbe5c86c0d98c17df0
https://pubmed.ncbi.nlm.nih.gov/30865372