Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Diane R. Umbenhauer"'
Autor:
Timothy E. Johnson, Xiaohua Zhang, Amy F Loughlin, Kimberly B. Bleicher, Diane R. Umbenhauer, Gary Dysart, William H. Schaefer
Publikováno v:
Toxicology and Applied Pharmacology. 200:237-250
Statins are widely used to treat lipid disorders. These drugs are safe and well tolerated; however, in
Autor:
Diane R. Umbenhauer, Joel P. Berger, Gaochao Zhou, Shiying Chen, David E. Moller, Jeffrey W. Lawrence, John G. DeLuca, Ying Li
Publikováno v:
Journal of Biological Chemistry. 276:31521-31527
We compared the ability of rat and human hepatocytes to respond to fenofibric acid and a novel potent phenylacetic acid peroxisome proliferator-activated receptor (PPAR) α agonist (compound 1). Fatty acyl-CoA oxidase (FACO) activity and mRNA were in
Publikováno v:
Toxicology and Applied Pharmacology. 143:357-365
A subpopulation of CF-1 mice is unusual in its sensitivity to the avermectins, abamectin and ivermectin, with neurotoxicity occurring at 100-fold lower doses than in other species and mouse strains. We have shown that the sensitive CF-1 mice are defi
Publikováno v:
Environmental and Molecular Mutagenesis. 28:51-59
Induced rat liver S-9 is routinely used for metabolic activation in cytogenetic assays. When a compound gives a positive test result only with rat S-9, the significance for humans should be assessed. To evaluate the use of human S-9, we used sister-c
Autor:
Lakshmi V. Mittal, Deborah R. Marino, George M. Laws, Kristy L. Kort, Thomas R. Skopek, Diane R. Umbenhauer, Stephen P. Adams
Publikováno v:
Environmental and Molecular Mutagenesis. 28:376-384
Big Blue (BB) and generic B6C3F1 mice were given one to three i.p. injections of 50 mg/kg benzo[a]pyrene (B[a]P) in DMSO every other day to achieve cumulative doses of 50 to 150 mg/kg. Three weeks after treatment, the mutation frequency at the endoge
Publikováno v:
Toxicology and applied pharmacology. 208(3)
Statins and fibrates (weak PPARalpha agonists) are prescribed for the treatment of lipid disorders. Both drugs cause myopathy, but with a low incidence, 0.1-0.5%. However, combined statin and fibrate therapy can enhance myopathy risk. We tested the m
Autor:
Diane R. Umbenhauer, Joseph F. Sina, Warren E. Glaab, Kimberly B. Bleicher, Todd Pippert, Thomas R. Skopek
Publikováno v:
Journal of biochemical and molecular toxicology. 15(3)
Exposure of rats to peroxisome proliferators induces members of the cytochrome P450 4A (CYP4A) family. In rats, the CYP4A family consists of four related genes, CYP4A1, CYP4A2, CYP4A3, and CYP4A8. We are specifically interested in examining CYP4A1, C
Autor:
Diane R. Umbenhauer, Todd Pippert
Publikováno v:
Journal of biochemical and molecular toxicology. 15(2)
A subpopulation of the CF-1 mouse strain is sensitive to neurotoxicity following exposure to avermectins, a family of structurally related antiparasitic agents. This unusual sensitivity is the result of a deficiency in the mdr1a P-glycoprotein that n
Publikováno v:
Reproductive toxicology (Elmsford, N.Y.). 12(4)
A subpopulation of the CF-1 mouse strain contains a spontaneous mutation in the P-glycoprotein (Pgp) mdr1a gene, which leads to a lack of mdr1a expression in the placenta as well as brain and intestine. Individual CF-1 mice can be identified accordin
Autor:
Todd Pippert, George R. Lankas, C M Beare, Mark E. Cartwright, L.D. Wise, Diane R. Umbenhauer, S J Hall
Publikováno v:
Toxicology and applied pharmacology. 146(1)
There is a subpopulation of the CF-1 mouse strain that is very sensitive to the neurotoxicity induced by the avermectins, a class of natural products widely used in veterinary and human medicine as anti-parasitic agents. This sensitivity results from