Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Diane R. Leone"'
Autor:
Humphrey Gardner, Allen M. Gown, Diane R. Leone, Glenna Heaney, Carl Reid, Patricia E. McCoon, Rebecca Kelly, Louise A. Koopman Van Aarsen, Kenneth Simon, Steffan Ho, Nianjun Tao, Marilyn Skelly, Stephen E. Fawell, Doreen J. LePage, Gareth J. Thomas, Gerald S. Horan, Paul Rayhorn, Shelia M. Violette, Brian M. Dolinski, Paul H. Weinreb
Publikováno v:
Cancer Research. 68:561-570
The αvβ6 integrin is up-regulated on epithelial malignancies and has been implicated in various aspects of cancer progression. Immunohistochemical analysis of αvβ6 expression in 10 human tumor types showed increased expression relative to normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5581d3915dde3774d2aab9c9cdeed3d2
https://doi.org/10.1158/0008-5472.can-07-2307
https://doi.org/10.1158/0008-5472.can-07-2307
Autor:
Marion G. Peters, Paul H. Weinreb, Bruce Wang, Brian M. Dolinski, D. Montgomery Bissell, Noriko Kikuchi, Shelia M. Violette, Diane R Leone
Publikováno v:
Hepatology. 46:1404-1412
The injury response in epithelia is highly focal or diffuse, depending on the nature of the injury factor and whether the process is acute or chronic. In the liver, the response may be localized to a portion of the lobule: the pericentral area (zone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e3b789c7831db34c9daa03b7da86a2
https://doi.org/10.1002/hep.21849
https://doi.org/10.1002/hep.21849
Autor:
Yi Luo, Raghu Kalluri, Matvey E. Lukashev, Diane R Leone, Roy R. Lobb, Brian M. Dolinski, Li Chun Wang, William Yang, Paul H. Weinreb, Kenneth Simon, Dean Sheppard, Donald J. McCrann, Kyungmin Hahm, Gerald S. Horan, Shelia M. Violette, Agnes B. Fogo, Norm Allaire, Charles F. Shield, Humphrey Gardner
Publikováno v:
The American Journal of Pathology. 170:110-125
The transforming growth factor (TGF)-beta-inducible integrin alpha v beta6 is preferentially expressed at sites of epithelial remodeling and has been shown to bind and activate latent precursor TGF-beta. Herein, we show that alpha v beta6 is overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4851d4538d75f908ff2d217148ce0534
https://doi.org/10.2353/ajpath.2007.060158
https://doi.org/10.2353/ajpath.2007.060158
Publikováno v:
Molecular Cancer Therapeutics. 4:91-99
In a syngeneic murine model of multiple myeloma with many of the characteristics of the human disease, a monoclonal antibody (mAb) to the integrin very late antigen-4 (VLA-4), given after the myeloma has already homed to and begun to establish itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4ff5b8f601f66b794108dfb46c0d624c
https://doi.org/10.1158/1535-7163.91.4.1
https://doi.org/10.1158/1535-7163.91.4.1
Autor:
Mark Cornebise, C. Nickerson-Nutter, Brian M. Dolinski, Stuart J. Perper, Steve Adams, Alan Gill, Diane R Leone, Doreen Lepage, Keith Giza, R. B. Pepinsky, L. L. Chen, Eric T. Whalley, Roy R. Lobb, K. Wortham, Petter Russell C, Daniel Scott, Wen-Cherng Lee, A. Chakraborty
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 312:742-750
Integrin alpha4beta1 plays an important role in inflammatory processes by regulating the migration of leukocytes into inflamed tissues. Previously, we identified BIO5192 [2(S)-{[1-(3,5-dichloro-benzenesulfonyl)-pyrrolidine-2(S)-carbonyl]-amino}-4-[4-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9daccf593e3e23af58b9231b1c686183
https://doi.org/10.1124/jpet.104.075648
https://doi.org/10.1124/jpet.104.075648
Autor:
Shelia M. Violette, Amha Atakilit, William Yang, Paul H. Weinreb, Diane R Leone, Kenneth Simon, Brian M. Dolinski, Yukako Yokota, Hisaaki Kawakatsu, Bradley R. Pearse, Dean Sheppard, Paul Rayhorn
Publikováno v:
Journal of Biological Chemistry. 279:17875-17887
We have generated a panel of potent, selective monoclonal antibodies that bind human and mouse alpha(v)beta(6) integrin with high affinity (up to 15 pm). A subset of these antibodies blocked the binding of alpha(v)beta(6) to the transforming growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81552be43cefec37fd61fc91aa05a50e
https://doi.org/10.1074/jbc.m312103200
https://doi.org/10.1074/jbc.m312103200
Autor:
Roy R. Lobb, Mark Cornebise, Russell C. Petter, C. Nickerson-Nutter, K. Wortham, Doreen Lepage, R. B. Pepinsky, Wen-Cherng Lee, Steve Adams, L. L. Chen, Daniel Scott, J. C. Spell, Brian M. Dolinski, Alan Gill, W. Yang, Keith Giza, Stuart J. Perper, Eric T. Whalley, Diane R Leone
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 305:1150-1162
Integrin alpha 4 beta 1 plays an important role in inflammatory processes by regulating the migration of lymphocytes into inflamed tissues. Here we evaluated the biochemical, pharmacological, and pharmacodynamic properties and efficacy in experimenta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08a2c9025a531d25a49df899c5a776c
https://doi.org/10.1124/jpet.102.047332
https://doi.org/10.1124/jpet.102.047332
Publikováno v:
Molecular cancer therapeutics. 4(1)
In a syngeneic murine model of multiple myeloma with many of the characteristics of the human disease, a monoclonal antibody (mAb) to the integrin very late antigen-4 (VLA-4), given after the myeloma has already homed to and begun to establish itself
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::41b5c182f7076d02793da31c68b47b6c
https://pubmed.ncbi.nlm.nih.gov/15657357
https://pubmed.ncbi.nlm.nih.gov/15657357
Autor:
Paul H, Weinreb, Kenneth J, Simon, Paul, Rayhorn, William J, Yang, Diane R, Leone, Brian M, Dolinski, Bradley R, Pearse, Yukako, Yokota, Hisaaki, Kawakatsu, Amha, Atakilit, Dean, Sheppard, Shelia M, Violette
Publikováno v:
The Journal of biological chemistry. 279(17)
We have generated a panel of potent, selective monoclonal antibodies that bind human and mouse alpha(v)beta(6) integrin with high affinity (up to 15 pm). A subset of these antibodies blocked the binding of alpha(v)beta(6) to the transforming growth f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::95efd9bf5b5da9e718eca7bb14d5289f
https://pubmed.ncbi.nlm.nih.gov/14960589
https://pubmed.ncbi.nlm.nih.gov/14960589
Autor:
Ashfaq Ahmed, Roy Lobb, Yelena Botinnikova, Ko-Chung Lin, Alan J. Gill, M. W. Sielczak, William M. Abraham, Diane R. Leone, Isabel T. Lauredo, Steven P. Adams, Blake Pepinsky
Publikováno v:
American journal of respiratory and critical care medicine. 162(2 Pt 1)
The leukocyte integrin very late antigen-4 (alpha(4)beta(1), CD49d/CD29) is an adhesion receptor that plays an important role in allergic inflammation and contributes to antigen-induced late responses (LAR) and airway hyperresponsiveness (AHR). In th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdb9f16a26d47baffb438e2460dd847
https://pubmed.ncbi.nlm.nih.gov/10934094
https://pubmed.ncbi.nlm.nih.gov/10934094