Výsledky vyhledávání - "Diane P Hanger"

Akademický článek

The importance of tau phosphorylation for neurodegenerative diseases

Autor: Wendy eNoble, Diane P Hanger, Christopher CJ Miller, Simon eLovestone

Publikováno v: Frontiers in Neurology, Vol 4 (2013)

Fibrillar deposits of highly phosphorylated tau are a key pathological feature of several neurodegenerative tauopathies including Alzheimer’s disease and some frontotemporal dementias. Increasing evidence suggests that the presence of these end-sta

Externí odkaz: https://doaj.org/article/ab1708c47dfa4f88abdb0cd42c9e759a

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Akademický článek

Anti-inflammatory impact of minocycline in a mouse model of tauopathy

Autor: Claire J Garwood, Jonathan D Cooper, Diane P Hanger, Wendy Noble

Publikováno v: Frontiers in Psychiatry, Vol 1 (2010)

Alzheimer’s disease (AD) is characterised by the extracellular deposition of β-amyloid in senile plaques, the intraneuronal accumulation of hyperphosphorylated tau aggregates as neurofibrillary tangles, and progressive neuronal loss leading to the

Externí odkaz: https://doaj.org/article/4b79d6b06b2a455a82fea88c158e7ba3

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Akademický článek

Corrigendum: The disease associated Tau35 fragment has an increased propensity to aggregate compared to full-length tau

Autor: Chen Lyu, Stefano Da Vela, Youssra Al-Hilaly, Karen E. Marshall, Richard Thorogate, Dmitri Svergun, Louise C. Serpell, Annalisa Pastore, Diane P. Hanger

Publikováno v: Frontiers in Molecular Biosciences, Vol 10 (2023)

Externí odkaz: https://doaj.org/article/8d84e8da21eb45a592eba0b8d3402fde

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Akademický článek

Barcodes distinguishing morphology of neuronal tauopathy

Autor: David Beers, Despoina Goniotaki, Diane P. Hanger, Alain Goriely, Heather A. Harrington

Publikováno v: Physical Review Research, Vol 5, Iss 4, p 043006 (2023)

This paper is part of the Physical Review Research collection titled Physics of Neuroscience. The geometry of neurons is known to be important for their functions. Hence, neurons are often classified by their morphology. Two recent methods, persisten

Externí odkaz: https://doaj.org/article/ee7ce11a733f463594edc8d568ecf651

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Akademický článek

A pathogenic tau fragment compromises microtubules, disrupts insulin signaling and induces the unfolded protein response

Autor: Tong Guo, Dina Dakkak, Teresa Rodriguez-Martin, Wendy Noble, Diane P. Hanger

Publikováno v: Acta Neuropathologica Communications, Vol 7, Iss 1, Pp 1-15 (2019)

Abstract Human tauopathies including Alzheimer’s disease, progressive supranuclear palsy and related disorders, are characterized by deposition of pathological forms of tau, synaptic dysfunction and neuronal loss. We have previously identified a pa

Externí odkaz: https://doaj.org/article/4ad5ef18337243a28630ef613a282fa8

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