Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Diane Mizel"'
Autor:
Jurgen Schnermann, Lanping Jiang, Limeng Chen, Mario Schiffer, Robert Faulhaber-Walter, Jeffrey B. Kopp, Diane Mizel, Patricia M. Zerfas
Publikováno v:
International Journal of Nephrology and Renovascular Disease. 13:19-26
Aim of Study To investigate podocyte density in aging diabetic Ins2± and Ins2±, A1AR-/- mouse models in C57Bl/6 background. Methods Ins2± mice and especially Ins2±, adenosine A1 receptor knockout mice (Ins2±, A1AR-/-) are mouse models with a phe
Autor:
Robert, Faulhaber-Walter, Lanping, Jiang, Diane, Mizel, Patricia M, Zerfas, Jeffrey B, Kopp, Jurgen B, Schnermann, Limeng, Chen, Mario, Schiffer
Publikováno v:
International Journal of Nephrology and Renovascular Disease
Aim of Study To investigate podocyte density in aging diabetic Ins2± and Ins2±, A1AR-/- mouse models in C57Bl/6 background. Methods Ins2± mice and especially Ins2±, adenosine A1 receptor knockout mice (Ins2±, A1AR-/-) are mouse models with a phe
Publikováno v:
American Journal of Physiology-Renal Physiology. 305:F1352-F1364
Deletions of claudin-2 (Cldn2) and aquaporin1 (AQP1) reduce proximal fluid reabsorption (PFR) by about 30% and 50%, respectively. Experiments were done to replicate these observations and to determine in AQP1/claudin-2 double knockout mice (DKO) if t
Autor:
Yuning Huang, Marion Hoerl, Jurgen Schnermann, Manfred Thiel, Lingli Li, Christoph Eisner, Diane Mizel
Publikováno v:
American Journal of Physiology-Renal Physiology. 304:F382-F389
A1 adenosine receptors (A1AR) are required for the modulation of afferent arteriolar tone by changes in luminal NaCl concentration implying that extracellular adenosine concentrations need to change in synchrony with NaCl. The present experiments wer
Autor:
En Yin Lai, Diane Mizel, Christoph Eisner, Christopher S. Wilcox, Yuning Huang, Lingli Li, Jurgen Schnermann
Publikováno v:
American Journal of Physiology-Renal Physiology. 303:F1166-F1175
Adenosine 1 receptors (A1AR) have been shown in previous experiments to play a major role in the tubuloglomerular feedback (TGF) constrictor response of afferent arterioles (AA) to increased loop of Henle flow. Overexpression studies have pointed to
Autor:
Diane Mizel, Christoph Eisner, Qin Yan, Xuzhen Hu, Richard J. Chen, Jeffrey B. Kopp, Robert A. Star, Elizabeth C. Wright, Yuning Huang, Asada Leelahavanichkul, Jurgen Schnermann, Peter S.T. Yuen, Hua Zhou
Publikováno v:
Kidney International. 78:1136-1153
The remnant kidney model in C57BL/6 mice does not develop progressive chronic kidney disease (CKD). In this study we modified the model to mimic features of human CKD and to define accelerants of disease progression using three strains of mice. Follo
Autor:
Diane Mizel, Christoph Eisner, Josephine P. Briggs, Mark Levine, Robert A. Star, Jurgen Schnermann, Robert Faulhaber-Walter, Yaohui Wang, Asada Leelahavanichkul, Peter S.T. Yuen
Publikováno v:
Kidney International. 77(6):519-526
This study was performed to quantify the fraction of excreted creatinine not attributable to creatinine filtration for accurately determining the glomerular filtration rate in mice. To measure this we compared creatinine filtration with the simultane
Autor:
Jurgen Schnermann, Diane Mizel, Susan M. Wall, Soo Mi Kim, Robert Faulhaber-Walter, Christoph Eisner, Josephine P. Briggs
Publikováno v:
American Journal of Physiology-Renal Physiology. 295:F1230-F1238
NKCC1 is a widely expressed isoform of the Na-2Cl-K cotransporter that mediates several direct and indirect vascular effects and regulates expression and release of renin. In this study, we used NKCC1-deficient (NKCC1−/−) and wild-type (WT) mice
Autor:
Josephine P. Briggs, Jurgen Schnermann, Mona Oppermann, Noriyuki Hiramatsu, Yuning Huang, Jeffrey B. Kopp, Hiroshi Kajiyama, Limeng Chen, Soo Mi Kim, Diane Mizel, Robert Faulhaber-Walter, Patricia M. Zerfas
Publikováno v:
Journal of the American Society of Nephrology. 19:722-730
Intraglomerular hypertension and glomerular hyperfiltration are suspected to play a major role in the pathogenesis of diabetic nephropathy.1 A variety of vasoactive systems have been found to be altered in diabetes, but no single vascular factor that
Autor:
Diane Mizel, Limeng Chen, Soo Mi Kim, Josephine P. Briggs, Yuning Huang, Mona Oppermann, Robert Faulhaber-Walter, Jurgen Schnermann
Publikováno v:
Hypertension. 50:103-109
The present experiments were performed in β1/β2-adrenergic receptor–deficient mice (β1/β2ADR −/− ) to assess the role of β-adrenergic receptors in basal and regulated renin expression and release. On a control diet, plasma renin concentrat