Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Diane Mary Coe"'
Autor:
Simon J. F. Macdonald, Graham I. Somers, Natalie Rayner, Tony W. J. Cooper, Iain Mcfarlane Mclay, James Michael Woolven, Simon Taylor, Rosemary Z. Sasse, Gordon G. Weingarten, Diane Mary Coe, Heather A. Barnett, Tracy Jane Shipley, Iain Uings, Phil A. Skone, Torquil I. Jack, Haydn Terence Jones
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:158-162
Aryl aminopyrazole amides capped with N-alkylbenzamides 13-16 are selective glucocorticoid receptor agonists. 2,6-Disubstituted benzamides have prednisolone-like potency or better in vitro. Good oral exposure was demonstrated in the rat, with compoun
Autor:
Eoghan M. McGarrigle, Johnathan V. Matlock, Diane Mary Coe, Varinder K. Aggarwal, Stephen A. Harrison, Sven P. Fritz
Publikováno v:
ChemInform. 46
The discovery of new methods for the synthesis of classes of potentially bioactive molecules remains an important goal for synthetic chemists. Vinylsulfonium salts have been used for the synthesis of a wide variety of small heterocyclic motifs; howev
Autor:
Johnathan V. Matlock, Stephen A. Harrison, Varinder K. Aggarwal, Eoghan M. McGarrigle, Diane Mary Coe, Sven P. Fritz
Publikováno v:
The Journal of organic chemistry. 79(21)
The discovery of new methods for the synthesis of classes of potentially bioactive molecules remains an important goal for synthetic chemists. Vinylsulfonium salts have been used for the synthesis of a wide variety of small heterocyclic motifs; howev
Autor:
Diane Mary Coe, Paul A. Clarke, Richard T. Buck, Neil D. Pearson, Leigh Ferris, Martin James Drysdale, David Haigh, Elizabeth Swann, Christopher J. Moody
Publikováno v:
Chemistry - A European Journal. 6:2160-2167
A different approach to the synthesis of dipeptides is described based on the formation of the NHCHR1CONH-CHR2CO bond by carbenoid N-H insertion, rather than the formation of the peptide bond itself. Thus decomposition of triethyl diazophosphonoaceta
Publikováno v:
Medicinal Research Reviews. 19:97-148
The current interest in solid-phase organic synthesis has led to a renewed interest in a complementary technique in which solid supported reagents are used in solution phase chemistry. This technique obviates the need for attachment of the substrate
Autor:
Martin James Drysdale, Neil D. Pearson, Richard T. Buck, Christopher J. Moody, Diane Mary Coe
Publikováno v:
Tetrahedron Letters. 39:7181-7184
New chiral dirhodium(II) carboxylate catalysts for asymmetric carbenoid SiH insertion reactions have been identified using solution phase parallel synthesis techniques.
Autor:
Richard Storer, Diane Mary Coe
Publikováno v:
Molecular Diversity. 4:31-38
The use of solution phase techniques has been explored as an alternative to solid-phase chemistry approaches for the preparation of arrays of compounds in the drug discovery process. Solution-phase work is free from some of the constraints of solid-p
Publikováno v:
ChemInform. 44
Protected galactals (I) (10 examples) are glycosylated with monosaccharide acceptors in the presence of thiourea catalyst THU to give disaccharides containing a 2-deoxymonosaccharide moiety.
Publikováno v:
Angewandte Chemie (International ed. in English). 51(36)
Alpha rules: A thiourea acts as an efficient organocatalyst for the glycosylation of protected galactals to form oligosaccharides containing a 2-deoxymonosaccharide moiety. The reaction is highly stereoselective for α-linkages and proceeds by way of
Autor:
Martin James Drysdale, Christopher J. Moody, Diane Mary Coe, Neil D. Pearson, Richard T. Buck
Publikováno v:
ChemInform. 29
New chiral dirhodium(II) carboxylate catalysts for asymmetric carbenoid SiH insertion reactions have been identified using solution phase parallel synthesis techniques.