Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Diane M. McMullen"'
Autor:
John T. Hunt, Suzanne Moreland, Maria L. Webb, Diane M. McMullen, Mark S. Bolgar, Ving G. Lee, Eddie C.-K. Liu
Publikováno v:
International Journal of Peptide and Protein Research. 42:249-258
While incorporation of penicillamine residues (Pen; beta,beta-dimethyl cysteine) into a peptide can cause dramatic changes in biological activity, the tendency of Pen to form mixed disulfides should also allow the exploitation of the steric bulk of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74d49487cd6c470cf58e6fdf4d712be9
https://doi.org/10.1111/j.1399-3011.1993.tb00139.x
https://doi.org/10.1111/j.1399-3011.1993.tb00139.x
Autor:
Steven Dzwonczyk, Gary J. Grover, Diane M. McMullen, Paul G. Sleph, Suzanne Moreland, Charles S. Parham, Diane E. Normandin
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:289-294
SummarySQ 32,926 and SQ 32,547, two dihydropyrimidine calcium channel blockers, were characterized as potent inhibitors of depolarization-induced contractions of isolated smooth muscle preparations. In rat aorta, the IC50 values were 5.5 nM for SQ 32
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bfa3bcf1e779dc4bab4331ebe7712b70
https://doi.org/10.1097/00005344-199508000-00015
https://doi.org/10.1097/00005344-199508000-00015
Autor:
Ving G. Lee, Eddie C.-K. Liu, Philip D. Stein, Diane M. McMullen, Suzanne Moreland, Anders Hedberg, John T. Hunt
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 1:33-38
Analogs of monocyclic ET-1 (Ala3,11, Nl7) containing substitutions were prepared and assayed for vasoconstrictor and receptor binding activity. Analogs substituted at residues Glu10, Phe14, Leu17 and Asp18 showed significant affinity for the receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c1c9e98c56976e8a35da1bc0acf3eac
https://doi.org/10.1016/s0960-894x(01)81085-4
https://doi.org/10.1016/s0960-894x(01)81085-4
Publikováno v:
Pfl�gers Archiv European Journal of Physiology. 417:180-184
Two regulatory systems are believed to control the contractile state of vascular smooth muscle in vitro. In one, crossbridges are phosphorylated by myosin light-chain (MLC) kinase; these phosphorylated crossbridges are believed to predominate during
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc629ab704e3949764cf91510143f7fb
https://doi.org/10.1007/bf00370697
https://doi.org/10.1007/bf00370697
1. There are at least two subtypes of vascular endothelin (ET) receptors. Stimulation of the ETA receptors on vascular smooth muscle cells leads to vasoconstriction, whereas activation of the ETB receptors on endothelial cells elicits vasodilatation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::facb05a0e0b280b9ab93799e46dbd8e8
https://europepmc.org/articles/PMC1910356/
https://europepmc.org/articles/PMC1910356/
Autor:
Philip D. Stein, Anders Hedberg, Eddie C.-K. Liu, David M. Floyd, Maria L. Webb, Sesha Natarajan, Stephen M. Festin, John T. Hunt, Rongan Zhang, Carol L. Delaney, Ving G. Lee, Randy Serafino, Diane M. McMullen, Mark S. Bolgar, Suzanne Moreland
Publikováno v:
Bioorganicmedicinal chemistry. 1(1)
With the goal of producing receptor antagonists, numerous monocyclic and bicyclic endothelin analogs were prepared and tested for vasoconstrictor activity, receptor affinity and functional antagonist activity. Bis-penicillamine endothelin analogs con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc4732d59372f7f3b989def3fa27cbb
https://pubmed.ncbi.nlm.nih.gov/8081838
https://pubmed.ncbi.nlm.nih.gov/8081838
Publikováno v:
Biochemical and biophysical research communications. 184(1)
Two endothelin (ET) receptor subtypes have been identified to date: the ETA receptor which preferentially binds ET-1 over ET-3, and the ETB receptor which is non-selective. This study characterized the ET receptor subtypes present in several vascular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea31ed361a34a3cd4dec0b9303c45e8
https://pubmed.ncbi.nlm.nih.gov/1314581
https://pubmed.ncbi.nlm.nih.gov/1314581
Autor:
Diane M. McMullen, Suzanne Moreland
Publikováno v:
Journal of cardiovascular pharmacology. 16(4)
The vasorelaxant activity of SQ 31,765 and diltiazem was studied in intact and Triton X-100 detergent-skinned fibers of the swine carotid media. Both calcium channel blockers were used to relax or prevent contractions induced by depolarization with 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5d477b68c72c1ebcf5d934a296b9e83
https://pubmed.ncbi.nlm.nih.gov/1706802
https://pubmed.ncbi.nlm.nih.gov/1706802
Autor:
Gary J. Grover, Steven Dzwonczyk, Diane M. McMullen, Diane E. Normandin, Charles S. Parham, Paul G. Sleph, Suzanne Moreland
Publikováno v:
Journal of Cardiovascular Pharmacology. 26:845
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b11364a4bbb18578ef68b1fdb1d81668
https://doi.org/10.1097/00005344-199511000-00023
https://doi.org/10.1097/00005344-199511000-00023