Zobrazeno 1 - 10
of 482
pro vyhledávání: '"Diane M, Simeone"'
Autor:
Ariane Lozac’hmeur, Tyler Danek, Qidi Yang, Mario G. Rosasco, John S. Welch, William Y. Go, Eric W. Ng, Armen Mardiros, David G. Maloney, Edward B. Garon, Kedar Kirtane, Diane M. Simeone, Julian R. Molina, Ameen A. Salahudeen, Michelle M. Stein, J. Randolph Hecht
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-9 (2024)
Abstract To enable interrogation of tumor HLA LOH as a clinical diagnostic for precision oncology, we developed and validated an assay that detects HLA LOH within the context of an FDA-approved clinical diagnostic test, Tempus xT CDx. Validation was
Externí odkaz:
https://doaj.org/article/b996755a54b34fbbaaef8cbd5b2d5b9a
Autor:
Marcela Maus, Caron Jacobson, Frederick L Locke, Oliver Dorigo, David Maloney, Jennifer Specht, Saurabh Dahiya, Edward Garon, Diane M Simeone, John Welch, Kedar Kirtane, Marwan Fakih, Julian Molina, Ariane Lozac’hmeur, J Randolph Hecht, Jong Chul Park, Caleb Smith, Theodore Welling, M Pia Morelli, Patrick M Grierson, Tomislav Dragovich, William Y Go, Eric W Ng, Peter Vu, Jessica Tebbets, Gayanie Ong
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/5184af672eaf45e98d7745abc3b7d258
Autor:
Sarah Nikiforow, Yi Lin, Marcela Maus, Armen Mardiros, Frederick L Locke, Scott Kopetz, Matthew Frigault, David Maloney, Jeffrey Ward, Jennifer Specht, Edward Garon, Diane M Simeone, John Welch, Kedar Kirtane, Marwan Fakih, Julian Molina, Kirstin Liechty, Ariane Lozac’hmeur, J Randolph Hecht, Caleb Smith, Salman R Punekar, Theodore Welling, M Pia Morelli, Patrick M Grierson, Sandip P Patel, Wen-Kai Weng, Tomislav Dragovich, Judy Vong, William Y Go, Eric W Ng
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/32d513fcdccc497db5f38b880ba6599e
Autor:
Gregor Werba, Daniel Weissinger, Emily A. Kawaler, Ende Zhao, Despoina Kalfakakou, Surajit Dhara, Lidong Wang, Heather B. Lim, Grace Oh, Xiaohong Jing, Nina Beri, Lauren Khanna, Tamas Gonda, Paul Oberstein, Cristina Hajdu, Cynthia Loomis, Adriana Heguy, Mara H. Sherman, Amanda W. Lund, Theodore H. Welling, Igor Dolgalev, Aristotelis Tsirigos, Diane M. Simeone
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC) is a complex ecosystem that drives tumor progression; however, in-depth single cell characterization of the PDAC TME and its role in response to therapy is lacking.
Externí odkaz:
https://doaj.org/article/3a27bc68fbda40dca2027e7c95c28684
Autor:
Jessica N. Everett, Shenin A. Dettwyler, Xiaohong Jing, Cody Stender, Madeleine Schmitter, Ariele Baptiste, Jennifer Chun, Emily A. Kawaler, Lauren G. Khanna, Seth A. Gross, Tamas A. Gonda, Nina Beri, Paul E. Oberstein, Diane M. Simeone
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 2345-2355 (2023)
Abstract Background Genetic testing is recommended for all pancreatic ductal adenocarcinoma (PDAC) patients. Prior research demonstrates that multidisciplinary pancreatic cancer clinics (MDPCs) improve treatment‐ and survival‐related outcomes for
Externí odkaz:
https://doaj.org/article/0f6a7df4ed6f4128a0db53d3b8d92eac
Autor:
Grace Oh, Annie Wang, Lidong Wang, Jiufeng Li, Gregor Werba, Daniel Weissinger, Ende Zhao, Surajit Dhara, Rosmel E. Hernandez, Amanda Ackermann, Sarina Porcella, Despoina Kalfakakou, Igor Dolgalev, Emily Kawaler, Talia Golan, Theodore H. Welling, Agnel Sfeir, Diane M. Simeone
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy that harbors mutations in homologous recombination–repair (HR-repair) proteins in 20%–25% of cases. Defects in HR impart a specific vulnerability to poly ADP ribose polymerase
Externí odkaz:
https://doaj.org/article/9914b8b0574846e7832524ad7f4fa02e
Autor:
Shanshan Wan, Ende Zhao, Daniel Freeman, Daniel Weissinger, Benjamin A. Krantz, Gregor Werba, Lauren G. Khanna, Despina Siolas, Paul E. Oberstein, Pratip K. Chattopadhyay, Diane M. Simeone, Theodore H. Welling
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/6be360b49cd24c50b826ca397853a428
Autor:
Aashna Karbhari, Sherly Mosessian, Kamaxi H Trivedi, Frank Valla, Mark Jacobson, Mark J Truty, Nandakumar G Patnam, Diane M Simeone, Elcin Zan, Tracy Brennan, Hongli Chen, Phillip H Kuo, Ken Herrmann, Ajit H Goenka
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294564 (2023)
BackgroundPancreatic ductal adenocarcinoma (PDAC) is a lethal disease prone to widespread metastatic dissemination and characterized by a desmoplastic stroma that contributes to poor outcomes. Fibroblast activation protein (FAP)-expressing Cancer-Ass
Externí odkaz:
https://doaj.org/article/d97e5dada246454a86bf00ed25ef44cc
Autor:
Shanshan Wan, Ende Zhao, Daniel Freeman, Daniel Weissinger, Benjamin A. Krantz, Gregor Werba, Lauren G. Khanna, Despina Siolas, Paul E. Oberstein, Pratip K. Chattopadhyay, Diane M. Simeone, Theodore H. Welling
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Hepato-pancreatico-biliary (HPB) malignancies are difficult-to-treat and continue to to have a high mortality and significant therapeutic resistance to standard therapies. Immune oncology (IO) therapies have demonstrated efficacy in several solid mal
Externí odkaz:
https://doaj.org/article/53dc33a9909e44bcaef5e0e3ab99ac19
Autor:
Jiaqi Shi, Zhujun Yi, Lin Jin, Lili Zhao, Alexander Raskind, Larisa Yeomans, Zeribe C. Nwosu, Diane M. Simeone, Costas A. Lyssiotis, Kathleen A. Stringer, Richard S. Kwon
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 11, Pp 1078-1088 (2021)
OBJECTIVES: Current standard of care imaging, cytology, or cystic fluid analysis cannot reliably differentiate malignant from benign pancreatic cystic neoplasms. This study sought to determine if the metabolic profile of cystic fluid could distinguis
Externí odkaz:
https://doaj.org/article/42a71ae8ee2146c2aebbad3ddbb265f9