Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Diane M, Hargrove"'
Autor:
Ying Zhang, Kirk Kozminski, Geoffrey S Harris, Halina Wisniewska, Karthik Srinivasan, Diane M. Hargrove, Beatriz Lindstrom, Kazimierz Wisniewski, Trudy A Kohout
Publikováno v:
Journal of Pharmaceutical Sciences. 111:247-261
The neuropeptide calcitonin gene-related peptide (CGRP) is known to play a central role in the underlying pathophysiology of migraine. In comparison to the effective triptan class of antimigraine treatments, the CGRP antagonists possess a comparable
Autor:
Sudarkodi Alagarsamy, Claudio D. Schteingart, Mark Lu, Karthik Srinivasan, Violetta Dimitriadou, Halina Wiśniewska, Regent Laporte, Jennifer Hartwig, Pierre Riviere, Kazimierz Wiśniewski, Steve Qi, Alexander P. Posch, Glenn Croston, Javier Sueiras-Diaz, Diane M. Hargrove
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 373:193-203
Glucagon-like peptide-2 (GLP-2) agonists have therapeutic potential in clinical indications in which the integrity or absorptive function of the intestinal mucosa is compromised, such as in short bowel syndrome (SBS). Native hGLP-2, a 33-amino acid p
Autor:
Priya Dhami, Gregory D. Ferguson, Emma Park, Kavita Panir, Andrew W Horne, Erin Greaves, Ashley Dorning, Chloe Hogg, James Karras, Diane M. Hargrove
Publikováno v:
Disease Models & Mechanisms
article-version (VoR) Version of Record
Dorning, A, Dhami, P, Panir, K, Hogg, C, Park, E, Ferguson, G D, Hargrove, D, Karras, J, Horne, A W & Greaves, E 2021, ' Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations ', Disease Models and Mechanisms, vol. 14, no. 8, dmm049070 . https://doi.org/10.1242/dmm.049070
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
article-version (VoR) Version of Record
Dorning, A, Dhami, P, Panir, K, Hogg, C, Park, E, Ferguson, G D, Hargrove, D, Karras, J, Horne, A W & Greaves, E 2021, ' Bioluminescent imaging in induced mouse models of endometriosis reveals differences in four model variations ', Disease Models and Mechanisms, vol. 14, no. 8, dmm049070 . https://doi.org/10.1242/dmm.049070
Disease Models & Mechanisms, Vol 14, Iss 8 (2021)
Our understanding of the aetiology and pathophysiology of endometriosis remains limited. Disease modelling in the field is problematic as many versions of induced mouse models of endometriosis exist. We integrated bioluminescent imaging of ‘lesions
Autor:
Halina Wiśniewska, Brian Ly, Diane M. Hargrove, Claudio D. Schteingart, Erin La, Hiroe Tariga, Glenn Croston, Gebhard Neyer, Karthik Srinivasan, Carlos Ortiz, Pierre Riviere, Steve Qi, Regent Laporte, Kazimierz Wiśniewski, John Kraus
Publikováno v:
Journal of Medicinal Chemistry. 62:4991-5005
The vasopressin analogue desmopressin (desamino-d-arginine8 vasopressin, dDAVP, 1) is a potent vasopressin 2 (V2) receptor (V2R) agonist approved in many countries for the treatment of diabetes insipidus, primary nocturnal enuresis, nocturia, and coa
Autor:
Kazimierz, Wiśniewski, Steve, Qi, John, Kraus, Brian, Ly, Karthik, Srinivasan, Hiroe, Tariga, Glenn, Croston, Erin, La, Halina, Wiśniewska, Carlos, Ortiz, Régent, Laporte, Pierre J-M, Rivière, Gebhard, Neyer, Diane M, Hargrove, Claudio D, Schteingart
Publikováno v:
Journal of medicinal chemistry. 62(10)
The vasopressin analogue desmopressin (desamino-d-arginine
Autor:
Pierre Riviere, John J. Dwyer, John Kraus, Claudio D. Schteingart, Guangcheng Jiang, Nicky Ferdyan, Jennifer Hartwig, Yung-Chih Wang, Kazimierz Wiśniewski, Karthik Srinivasan, Steve Qi, Mark Lu, Dorain Thompson, Sudarkodi Alagarsamy, Monica Mares, Regent Laporte, Halina Wiśniewska, Robert Galyean, Alexander P. Posch, Glenn Croston, Javier Sueiras-Diaz, Diane M. Hargrove
Publikováno v:
Journal of Medicinal Chemistry. 59:3129-3139
Glucagon-like peptide-2 receptor agonists have therapeutic potential for the treatment of intestinal diseases. The native hGLP-2, a 33 amino acid gastrointestinal peptide, is not a suitable clinical candidate, due to its very short half-life in human
Publikováno v:
European journal of pharmacology. 824
Gonadotropin releasing hormone (GnRH) analogs have long been used in androgen deprivation therapy (ADT) in the treatment of prostate cancer. Chronic administration of either GnRH agonists or antagonists leads to suppression of testosterone production
Autor:
Diane M. Hargrove, Alexander P. Posch, Christian Meyer, Pierre Riviere, Porter Richard Hugh Phillip, Violetta Dimitriadou, Regent Laporte, Luca Santarelli
Publikováno v:
Transplantation. 103:S105-S105
Autor:
Stéphane De Lombaert, Diane M. Hargrove, Christine M. Mack, Charles A. Blum, David A. Griffith, Martin Sanders, Colin R. Rose, Tristan S. Maurer, John Inthavongsay, Lee E. Klade, Philip A. Carpino
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:2641-2645
A novel series of pyrazolo[1,5-a]pyrimidine derivatives was synthesized and evaluated as NPY Y1R antagonists. High binding affinity and selectivity were achieved with C3 trisubstituted aryl groups and C7 substituted 2-(tetrahydro-2H-pyran-4-ylamino)e
Autor:
Melissa L. Gillaspy, Diane M. Hargrove, Mary E. Lame, Paul Da Silva Jardine, Dennis O. Scott, Catherine E. Trebino, Yingxin Zhang, Kimberly O. Cameron, Richard L. Elliott, Kelly A. Martin, Janice E. Chin, Elena E. Beretta, Swick Andrew Gordon, Jeffrey S. Dubins, Janet A. LaFlamme, Dexue Sun, Tristan S. Maurer, Nancy A. Nardone, Amit S. Kalgutkar, Jeremy A. Bartlett, Robert M. Oliver, Yue Chen
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6797-6801
We describe the design, synthesis, and structure-activity relationships of triazolobenzodiazepinone CCK1 receptor agonists. Analogs in this series demonstrate potent agonist activity as measured by in vitro and in vivo assays for CCK1 agonism. Our ef