Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Diane Lee Bakaysa"'
Autor:
Mark A. Heady, Maureen A. Bell, Diane Lee Bakaysa, Susan Pye, Shun Li, Karen M. Youngman, Jerry Radziuk, Bruce H. Frank, Michael Rosario Defelippis
Publikováno v:
Journal of Pharmaceutical Sciences. 87:170-176
Soluble preparations of [LysB28,ProB29]-human insulin analogue (LysPro) exhibit more rapid absorption than human insulin upon subcutaneous injection. Biphasic mixtures of LysPro and intermediate-acting insulin suspensions could provide advantages ove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd576b89107bd140ba9b67a553afad03
https://doi.org/10.1021/js970285m
https://doi.org/10.1021/js970285m
Autor:
David N. Brems, Steven Witt Dodd, Jerry Radziuk, Shun Li, Diane Lee Bakaysa, Allen H. Pekar, John Michael Beals, Mark L. Brader, Henry A. Havel
Publikováno v:
Protein Science. 5:2521-2531
The rate-limiting step for the absorption of insulin solutions after subcutaneous injection is considered to be the dissociation of self-associated hexamers to monomers. To accelerate this absorption process, insulin analogues have been designed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09510b7233cf72524da7698df4d99daa
https://doi.org/10.1002/pro.5560051215
https://doi.org/10.1002/pro.5560051215
Autor:
Alita Miller, Steven R. Maple, Allen H. Pekar, Donald B. Spencer, David N. Brems, Christopher Bryant, Diane Lee Bakaysa, Karen S. McCune
Publikováno v:
Biochemistry. 32:8075-8082
The effect of pH on the conformational stability of insulin was studied. Surprisingly, the Gibbs free energy of unfolding increased approximately 30% by acidification. pH titration of insulin's conformational stability is described by a transition in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbfb6fb7d884e176aa2a23207375ba8
https://doi.org/10.1021/bi00083a004
https://doi.org/10.1021/bi00083a004
Publikováno v:
Protein Engineering, Design and Selection.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e7c4d01997e1eaa4d6c45070b6525845
https://doi.org/10.1093/protein/6.supplement.8-b
https://doi.org/10.1093/protein/6.supplement.8-b