Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Diane Lebesgue"'
Autor:
Diane Lebesgue, Michael Traub, Maxine De Butte-Smith, Christopher Chen, R Suzanne Zukin, Martin J Kelly, Anne M Etgen
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8642 (2010)
Pretreatment with 17beta-estradiol (E2) is profoundly neuroprotective in young animals subjected to focal and global ischemia. However, whether E2 retains its neuroprotective efficacy in aging animals, especially when administered after brain insult,
Externí odkaz:
https://doaj.org/article/30cf4247503e4abfa98385e530d46cac
Autor:
Veronica V. Gonzalez, Jun Shu, Diane Lebesgue, Matthew A. Lederman, Genevieve Neal-Perry, Anne M. Etgen, Zaher Merhi
Publikováno v:
Neuropharmacology. 58:314-320
Female reproductive aging in rats is characterized by reduced gonadotropin releasing hormone (GnRH) neuronal activation under estradiol positive feedback conditions and a delayed and attenuated luteinizing hormone (LH) surge. The newly identified exc
Publikováno v:
Steroids. 74:555-561
The potential neuroprotective role of sex hormones in chronic neurodegenerative disorders and acute brain ischemia following cardiac arrest and stroke is of a great therapeutic interest. Long-term pretreatment with estradiol and other estrogens affor
Autor:
Genevieve Neal-Perry, Diane Lebesgue, Matthew A. Lederman, Jun Shu, Anne M. Etgen, Gail D. Zeevalk
Publikováno v:
Endocrinology. 150:3699-3708
Reproductive success depends on a robust and appropriately timed preovulatory LH surge. The LH surge, in turn, requires ovarian steroid modulation of GnRH neuron activation by the neuropeptide kisspeptin and glutamate and γ-aminobutyric acid (GABA)
Publikováno v:
Molecular Pharmacology. 58:373-379
We previously demonstrated that the monoclonal antibody Mab6H8 raised against the second extracellular loop of the beta(2)-adrenoceptor (beta(2)-AR) had an agonist-like activity, mediated by the activation of L-type Ca(2+) channels by protein kinase
Publikováno v:
European Journal of Pharmacology. 348:123-133
Monoclonal antibodies were produced against a peptide corresponding to the second extracellular loop of the human beta2-adrenoceptor. One of these monoclonals, inducing an agonist-like effect in neonatal rat cardiomyocytes, was used to define the str
Rapid, nongenomic actions of 17beta-oestradiol (E(2)) on hypothalamic neurones that may be relevant to reproductive function were described decades ago. The orphan G protein-coupled receptor, GPR30, was recently shown to bind oestrogens and to trigge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101dea18672964490eebddc9a9a98333
https://europepmc.org/articles/PMC2756443/
https://europepmc.org/articles/PMC2756443/
Publikováno v:
Hormones and behavior. 49(2)
Transient global ischemia induces selective, delayed neuronal death in the hippocampal CA1 and delayed cognitive deficits. Estrogen treatment ameliorates hippocampal injury associated with global ischemia. Although much is known about the impact of e
Autor:
Moritz Gröger, Nikolaus Plesnila, Jürg Nussberger, Diane Lebesgue, Jane K. Relton, Seong-Woong Kim, D. Pruneau
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 25(8)
Pharmacological studies using bradykinin B2receptor antagonists suggest that bradykinin, an early mediator of inflammation and the main metabolite of the kallikrein-kinin system, is involved in secondary brain damage after cerebral ischemia. However,
Autor:
Michel Bouvier, Mireille Hogue, Eric Le Carpentier, Diane Lebesgue, Yves Durocher, Amine Kamen
Publikováno v:
Protein expression and purification. 23(1)
Using the baculovirus/insect-cell expression vector system, we succeeded in obtaining a high yield of active human β 2 -adrenergic receptor/G αs fusion protein. This was achieved following high cell density production under nutrient-limiting condit