Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Diane L. Negley"'
Publikováno v:
The Journal of Infectious Diseases. 196:S305-S312
The complete genome sequences of 2 closely related plaque-derived variants of Marburg virus (MARV) species Lake Victoria marburgvirus, strain Musoke, indicate only a few regions of the RNA genome as underlying the differences between the 2 viruses. O
Autor:
Kelly L. Warfield, Alan L. Schmaljohn, M. Javad Aman, Sina Bavari, Dana L. Swenson, Diane L. Negley
Publikováno v:
Vaccine. 22:3495-3502
Ongoing outbreaks of filoviruses in Africa and concerns about their use in bioterrorism attacks have led to intense efforts to find safe and effective vaccines to prevent the high mortality associated with these viruses. We previously reported the ge
Publikováno v:
Journal of Virological Methods. 119:195-198
Many assume that common methods to extract viral nucleic acids are able to render a sample non-infectious. It may be that inactivation of infectious virus is incomplete during viral nucleic acid extraction methods. Accordingly, two common viral nucle
Autor:
Alan L. Schmaljohn, Robert J. Hogan, Case C. Grogan, M. Javad Aman, Diane L. Negley, Sina Bavari, Catharine M. Bosio, Mansour Mohamadzadeh, Gordon Ruthel
Publikováno v:
The Journal of Infectious Diseases. 188:1630-1638
Ebola virus (EBOV) and Marburg virus (MARV) cause rapidly progressive hemorrhagic fever with high mortality and may possess specialized mechanisms to evade immune destruction. We postulated that immune evasion could be due to the ability of EBOV and
Autor:
Lorna Vanderzanden, Mary Kate Hart, Joan B. Geisbert, Peter B. Jahrling, Alan L. Schmaljohn, Diane L. Negley, Anthony D. Bassett, Michael Hevey, Albert Ruff, Aura R. Garrison, Connie S. Schmaljohn, Mike Bray, Jenny Riemenschneider, Bruce E. Ivins, John S. Lee, Cynthia A. Rossi, David Custer
Publikováno v:
Vaccine. 21:4071-4080
Multiagent DNA vaccines for highly pathogenic organisms offer an attractive approach for preventing naturally occurring or deliberately introduced diseases. Few animal studies have compared the feasibility of combining unrelated gene vaccines. Here,
Autor:
Alan L. Schmaljohn, Lorna Vanderzanden, Michael Hevey, Jonathan F. Smith, Connie S. Schmaljohn, Diane L. Negley, Ralph Tammariello, Peter B. Jahrling, Joan B. Geisbert
Publikováno v:
Vaccine. 20:586-593
An effort to develop a safe and effective vaccine for Marburg virus (MBGV), one of the filoviruses known to cause high mortality rates in humans, led us to compare directly some of the merits of modern versus classical vaccine approaches for this age
Publikováno v:
Virology. 239:206-216
There is no effective vaccine for Marburg virus (MBGV) or any other filovirus, nor enough pertinent information to expedite rational vaccine development. To ascertain some of the minimal requirements for a MBGV vaccine, we determined whether whole in
Autor:
Alan L. Schmaljohn, Connie S. Schmaljohn, Michael S. Ascher, George W. Korch, Dexin Li, Diane L. Negley, Michael J. Turell, David S. Bressler
Publikováno v:
Virology. 206:963-972
A fatal case of hantavirus pulmonary syndrome (HPS) in northern California prompted our attempt to isolate viruses from local rodents. From tissues of two deer mice, Peromyscus maniculatus, two hantaviruses (Convict Creek virus 107 and 74, CC107 and
Autor:
Leonard A. Smith, Angela G. Hadjipanayis, Alan L. Schmaljohn, John S. Lee, Jonathan F. Smith, Jennifer L. Groebner, Susan L. Welkos, Diane L. Negley
Publikováno v:
Vaccine. 24(47-48)
The development of multiagent vaccines offers the advantage of eliciting protection against multiple diseases with minimal inoculations over a shorter time span. We report here the results of using formulations of individual Venezuelan equine encepha
Autor:
Kelly L. Warfield, Emily M. Deal, Mary Kate Hart, Dana L. Swenson, Gene G. Olinger, Michael Bailey, Diane L. Negley, Sina Bavari
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 175(2)
Ebola virus (EBOV)-like particles (eVLP), composed of the EBOV glycoprotein and matrix viral protein (VP)40 with a lipid membrane, are a highly efficacious method of immunization against EBOV infection. The exact requirements for immunity against EBO