Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Diane L. Lynch"'
Autor:
Kevin Wu, Samuel Itskanov, Diane L. Lynch, Yuanyuan Chen, Aasha Turner, James C. Gumbart, Eunyong Park
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Doa10 (MARCHF6 in metazoans) is a large polytopic membrane-embedded E3 ubiquitin ligase in the endoplasmic reticulum (ER) that plays an important role in quality control of cytosolic and ER proteins. Although Doa10 is highly conserved across
Externí odkaz:
https://doaj.org/article/be2e86f1e3154106b7a2c1e7f41a8492
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Molecular dynamics simulations and enhanced sampling methods reveal the role of glycans and the energetics of glycan-mediated conformational switches in the receptor binding domains of the SARS-CoV-2 trimeric spike glycoprotein.
Externí odkaz:
https://doaj.org/article/7dd6b0f1daf445fea34c23d96fb193d8
Publikováno v:
Frontiers in Molecular Biosciences, Vol 7 (2020)
The transient receptor potential subfamily vanilloid type 1 ion channel (TRPV1), located in the peripheral nervous system has been implicated in the perception of pain and possesses the ability to be modulated by various cannabinoid ligands. Because
Externí odkaz:
https://doaj.org/article/98eb59aeafc64eaca56fd1c630026aed
Autor:
Israa H. Isawi, Paula Morales, Noori Sotudeh, Dow P. Hurst, Diane L. Lynch, Patricia H. Reggio
Publikováno v:
Molecules, Vol 25, Iss 3, p 725 (2020)
GPR6 is an orphan G protein-coupled receptor that has been associated with the cannabinoid family because of its recognition of a sub-set of cannabinoid ligands. The high abundance of GPR6 in the central nervous system, along with high constitutive a
Externí odkaz:
https://doaj.org/article/b29654b473574beeb8a32aa15d7b44d4
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 9, p 2300 (2019)
The orphan G-protein coupled receptor (GPCR), GPR18, has been recently proposed as a potential member of the cannabinoid family as it recognizes several endogenous, phytogenic, and synthetic cannabinoids. Potential therapeutic applications for GPR18
Externí odkaz:
https://doaj.org/article/6c46e5d7808b475a894849a53c86582c
Publikováno v:
Journal of Chemical Theory and Computation.
Autor:
Anna Pavlova, Leda Bassit, Bryan D. Cox, Maksym Korablyov, Christophe Chipot, Dharmeshkumar Patel, Diane L. Lynch, Franck Amblard, Raymond F. Schinazi, James C. Gumbart
Publikováno v:
J Med Chem
Interfering with the self-assembly of virus nucleocapsids is a promising approach for the development of novel antiviral agents. Applied to hepatitis B virus (HBV), this approach has led to several classes of capsid assembly modulators (CAMs) that ta
Publikováno v:
Journal of Chemical Information and Modeling. 61:5742-5746
The capsaicin receptor, transient receptor potential vanilloid type 1 (TRPV1), is a polymodal channel that has been implicated in the perception of pain and can be modulated by a variety of cannabinoid ligands. Here we report TRPV1 channel activation
Autor:
Chris Chipot, Zhongyu Mou, Diane L. Lynch, Anna Pavlova, Yui Tik Pang, James C. Gumbart, Atanu Acharya, Zijian Zhang, Jerry M. Parks
Publikováno v:
The Journal of Physical Chemistry Letters
SARS-CoV and SARS-CoV-2 bind to the human ACE2 receptor in practically identical conformations, although several residues of the receptor-binding domain (RBD) differ between them. Herein, we have used molecular dynamics (MD) simulations, machine lear
Publikováno v:
Biophysical Journal. 122:20a