Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Diane L. Lanza"'
Autor:
William J. Ehlhardt, Hao Sun, Garold S. Yost, Christopher A. Reilly, Diane L. Lanza, Palaniappan Kulanthaivel
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 322:843-851
Indoline derivatives possess therapeutic potential within a variety of drug candidates. In this study, we found that indoline is aromatized by cytochrome P450 (P450) enzymes to produce indole through a novel dehydrogenation pathway. The indole produc
Autor:
Christopher A. Reilly, Mark E. Johansen, Ashwini S. Sabnis, Garold S. Yost, Philip J. Moos, Karen C. Thomas, Diane L. Lanza
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 321:830-838
Transient receptor potential vanilloid 1 (TRPV1) is a calcium-selective ion channel expressed in human lung cells. We show that activation of the intracellular subpopulation of TRPV1 causes endoplasmic reticulum (ER) stress and cell death in human br
Publikováno v:
Toxicology and Applied Pharmacology. 213:135-144
Epoxyeicosatrienoic acids produced by mouse CYP2B19 have been implicated in mechanisms regulating epidermal cornification (Ladd, P.A., Du, L., Capdevila, J.H., Mernaugh, R., Keeney, D.S., 2003. Epoxyeicosatrienoic acids activate transglutaminases in
Publikováno v:
Archives of Biochemistry and Biophysics. 349:329-340
Members of the CYP2F gene subfamily are selectively expressed in lung tissues and have been implicated as important catalysts in the formation of reactive intermediates from several pneumotoxic chemicals. Human CYP2F1 bioactivates 3-methylindole (3MI
Autor:
Mark E. Johansen, Ju-Ok Lim, Jeewoo Lee, Garold S. Yost, Christopher A. Reilly, Diane L. Lanza
Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death. The purpose of this study was to investigate the role of TRPV1-media
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c89a96f68ebb9f86481461486dbe99
https://europepmc.org/articles/PMC2291358/
https://europepmc.org/articles/PMC2291358/
Autor:
Andrea C, Simmonds, Christopher A, Reilly, R Michael, Baldwin, Burhan I, Ghanayem, Diane L, Lanza, Garold S, Yost, Kathy S, Collins, Poh-Gek, Forkert
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 32(9)
1,1-Dichloroethylene (DCE) exposure to mice elicits lung toxicity that selectively targets bronchiolar Clara cells. The toxicity is mediated by DCE metabolites formed via cytochrome P450 metabolism. The primary metabolites formed are DCE epoxide, 2,2
Autor:
Martha M. Veranth, Charles Langelier, Garold S. Yost, John M. Veranth, Christopher A. Reilly, Diane L. Lanza, Tyler A. Moss
Cultured human lung epithelial cells (BEAS-2B) were treated in vitro with PM(2.5)-enriched particles of soil-derived mineral dust from nine sites in the western United States. The particle samples simulate windblown dust and vehicle-generated emissio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1778993b92becf66ffa539977ff11d6
https://europepmc.org/articles/PMC2292468/
https://europepmc.org/articles/PMC2292468/
Autor:
Franklyn B. Garry, Bruce W. Hoffman, Leon J. Mills, Daniel H. Gould, Diane L. Lanza, Gary L. Mason, Garold S. Yost, Delbert G. Miles, Guy H. Loneragan
Publikováno v:
American journal of veterinary research. 62(10)
Objective—To compare concentrations of 3-methyleneindolenine (3MEIN) in lung tissues obtained from feedlot cattle that died as a result of acute interstitial pneumonia (AIP) and cattle that died as a result of other causes and to compare blood conc
Publikováno v:
Chemical research in toxicology. 11(7)
The existence of a cytochrome P450-dependent 2,3-epoxide of the potent pneumotoxin 3-methylindole was indirectly confirmed using stable isotope techniques and mass spectrometry. Determination of hydride shift and incorporation of labeled oxygen in 3-