Výsledky vyhledávání - "Diane L Rossi"

Akademický článek

Evaluation of a novel hexavalent humanized anti-IGF-1R antibody and its bivalent parental IgG in diverse cancer cell lines.

Autor: Chien-Hsing Chang, Yang Wang, Preeti Trisal, Rongxiu Li, Diane L Rossi, Anju Nair, Pankaj Gupta, Michele Losman, Thomas M Cardillo, Edmund A Rossi, David M Goldenberg

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e44235 (2012)

A major mechanism of monoclonal antibodies that selectively target the insulin-like growth factor type 1 receptor (IGF-1R) to inhibit tumor growth is by downregulating the receptor, regardless whether they are capable (antagonistic) or incapable (ago

Externí odkaz: https://doaj.org/article/911314e583d9433abb57d0f3190e46a9

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Data from IMMU-140, a Novel SN-38 Antibody–Drug Conjugate Targeting HLA-DR, Mediates Dual Cytotoxic Effects in Hematologic Cancers and Malignant Melanoma

Autor: David M. Goldenberg, Chien-Hsing Chang, Yang Wang, Diane L. Rossi, Maria B. Zalath, Serengulam V. Govindan, Thomas M. Cardillo

HLA-DR is a member of the MHC class II antigen family expressed on hematologic and solid tumors. Antibodies directed against HLA-DR have demonstrated some clinical success, but toxicities limited development. IMMU-140 is an anti–HLA-DR antibody–d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::379d0d89af3cea5f958795f16cd8a214
https://doi.org/10.1158/1535-7163.c.6537790.v1

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Data Supplement from Redirected T-Cell Killing of Solid Cancers Targeted with an Anti-CD3/Trop-2–Bispecific Antibody Is Enhanced in Combination with Interferon-α

Autor: David M. Goldenberg, Chien-Hsing Chang, Thomas M. Cardillo, Diane L. Rossi, Edmund A. Rossi

Supplementary Figure S9. Induction of cytokine release by (19)-3s and 19-3 BiTE from PBMCs in the presence of Raji NHL cells. Results show the levels of TNF-α, IFN-γ and IL-6 after 20-h treatment with titrations of bsAb.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2254e5a0b0025b062c9ea53a8022722c
https://doi.org/10.1158/1535-7163.22502877.v1

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Data from Synthetic Lethality Exploitation by an Anti–Trop-2-SN-38 Antibody–Drug Conjugate, IMMU-132, Plus PARP Inhibitors in BRCA1/2–wild-type Triple-Negative Breast Cancer

Autor: David M. Goldenberg, Ali A. Mostafa, Roberto Arrojo, Diane L. Rossi, Robert M. Sharkey, Thomas M. Cardillo

Purpose: Both PARP inhibitors (PARPi) and sacituzumab govitecan (IMMU-132) are currently under clinical evaluation in triple-negative breast cancer (TNBC). We sought to investigate the combined DNA-damaging effects of the topoisomerase I (Topo I)–i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04c2471e9a5ccca3cb8435219d14b844
https://doi.org/10.1158/1078-0432.c.6525120

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Data from Combination Therapy with Bispecific Antibodies and PD-1 Blockade Enhances the Antitumor Potency of T Cells

Autor: David M. Goldenberg, Thomas M. Cardillo, Edmund A. Rossi, Donglin Liu, Diane L. Rossi, Rongxiu Li, Yang Wang, Chien-Hsing Chang

The DOCK-AND-LOCK (DNL) method is a platform technology that combines recombinant engineering and site-specific conjugation to create multispecific, multivalent antibodies of defined composition with retained bioactivity. We have applied DNL to gener

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ed825e6559464d833d274bce85fe62
https://doi.org/10.1158/0008-5472.c.6508899.v1

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Table S1, Table S2, table S3, and Table S4 from Combination Therapy with Bispecific Antibodies and PD-1 Blockade Enhances the Antitumor Potency of T Cells

Autor: David M. Goldenberg, Thomas M. Cardillo, Edmund A. Rossi, Donglin Liu, Diane L. Rossi, Rongxiu Li, Yang Wang, Chien-Hsing Chang

Combined file of Table S1 thru S4. Table S1. Blockade of PD-1 binding to PD-L1 on MDA-MB-231 by anti-PD-1. Table S2. Surface expression of CEACAM5 and Trop-2 on selective cell lines. Table S3. Expression of Trop-2 and PD-L1 on MDA-MB-231 and its Trop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74f19fc8d7840bb67467f9b755853f52
https://doi.org/10.1158/0008-5472.22414131

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Figure S1, Figure S2, Figure S3, Figure S4, and Figure S5 from Combination Therapy with Bispecific Antibodies and PD-1 Blockade Enhances the Antitumor Potency of T Cells

Autor: David M. Goldenberg, Thomas M. Cardillo, Edmund A. Rossi, Donglin Liu, Diane L. Rossi, Rongxiu Li, Yang Wang, Chien-Hsing Chang

Combined file of Fig.S1 thru Fig.S5 - Fig. S1. Biochemical characterization of 5G9.G1.B11. Fig. S2. Binding of 5G9.G1.B11 to native PD-1. Fig. S3. Blocking activities of 5G9.G1.B11. Fig. S4. Biochemical characterization of cPD-1. Fig. S5. Binding of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a016b0f8fe72cde4d1e3875b98d978b6
https://doi.org/10.1158/0008-5472.22414149.v1

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