Výsledky vyhledávání - "Diane L, Nabb"

Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial

Autor: John A. Weeks, Marlies Halder, Helmut Segner, Christian Schlechtriem, John W. Nichols, Ina Bischof, Jing Hu, John W. Davis, Joe Swintek, Michelle R. Embry, Karla Johanning, Kellie A. Fay, Diane L. Nabb, Heike Laue, Mary Jo Bernhard

Publikováno v: Nichols, John; Fay, Kellie; Bernhard, Mary Jo; Bischof, Ina; Davis, John; Halder, Marlies; Hu, Jing; Johanning, Karla; Laue, Heike; Nabb, Diane; Schlechtriem, Christian; Segner, Helmut; Swintek, Joe; Weeks, John; Embry, Michelle (2018). Reliability of In Vitro Methods Used to Measure Intrinsic Clearance of Hydrophobic Organic Chemicals by Rainbow Trout: Results of an International Ring Trial. Toxicological sciences, 164(2), pp. 563-575. Oxford University Press 10.1093/toxsci/kfy113
Toxicological Sciences

In vitro assays are widely employed to obtain intrinsic clearance estimates used in toxicokinetic modeling efforts. However, the reliability of these methods is seldom reported. Here we describe the results of an international ring trial designed to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c166180a731a81711055f69c440a52
https://boris.unibe.ch/129626/1/kfy113.pdf

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Aquatic hazard, bioaccumulation and screening risk assessment for 6:2 fluorotelomer sulfonate

Autor: Robert A. Hoke, Terry L. Sloman, Robert C. Buck, Robert T. Mingoia, Stephen H. Korzeniowski, Timothy W. Ryan, Diane L. Nabb, John W. Green, Barbra D. Ferrell

Publikováno v: Chemosphere. 128:258-265

This study assessed the aquatic toxicity and bioaccumulation potential of 6:2 fluorotelomer sulfonate (6:2 FTSA). Acute and chronic aquatic hazard endpoints indicate 6:2 FTSA is not classified for aquatic hazard according to GHS or European CLP legis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64d8689a596ad85b5031e2d8933cee6
https://doi.org/10.1016/j.chemosphere.2015.01.033

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Endocrine Disruption Screening by Protein and Gene Expression of Vitellogenin in Freshly Isolated and Cryopreserved Rainbow Trout Hepatocytes

Autor: Jianhong Yao, Xing Han, Stephanie M. Waters, James P. Finn, Robert T. Mingoia, Diane L. Nabb, Heather M. Peterson, Lauren K. Markell

Publikováno v: Chemical Research in Toxicology. 27:1450-1457

Xenobiotics may activate the estrogen receptor, resulting in alteration of normal endocrine functions in animals and humans. Consequently, this necessitates development of assay end points capable of identifying estrogenic xenobiotics. In the present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965e015750c2686c40bebb17a02856f3
https://doi.org/10.1021/tx5002089

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Key Learnings from Performance of the U.S. EPA Endocrine Disruptor Screening Program (EDSP) Tier 1 In Vitro Assays

Autor: Katie Coady, Suzanne I. Snajdr, Matthew J. LeBaron, Lauren K. Markell, M. Sue Marty, John C. O'Connor, Diane L. Nabb

Publikováno v: Birth Defects Research Part B: Developmental and Reproductive Toxicology. 101:23-42

Tier 1 of the U.S. EPA Endocrine Disruptor Screening Program comprises 11 studies: five in vitro assays, four in vivo mammalian assays, and two in vivo nonmammalian assays. The battery is designed to detect compounds with the potential to interact wi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905647f37a3af93e8db0686a80690405
https://doi.org/10.1002/bdrb.21094

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Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice

Autor: Shawn A. Gannon, Diane L. Nabb, Tessa L. Serex, Scott E. Loveless, Terry L. Johnson, Robert C. Buck

Publikováno v: Toxicology. 283:55-62

The absorption, tissue distribution, elimination, and metabolism of [1-¹⁴C]-PFHx in rats and mice dosed orally at 2 or 100 mg/kg was evaluated following a single dose or after 14 consecutive doses. Absorption was rapid in rats as evidenced by a sh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43a008c001dc9bdd0382a835c2d2b3dc
https://doi.org/10.1016/j.tox.2011.02.004

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Cryopreserved Hepatocytes from Rainbow Trout (Oncorhynchus mykiss): A Validation Study to Support Their Application in Bioaccumulation Assessment

Autor: Ching-Hui Yang, Diane L. Nabb, Robert T. Mingoia, Kyle P. Glover, Suzanne I. Snajdr, Xing Han

Publikováno v: Environmental Science & Technology. 44:3052-3058

Determination of biotransformation rates of xenobiotics in freshly isolated trout hepatocytes has been demonstrated to significantly improve the performance of bioaccumulation assessment models. In order to promote this in vitro approach, trout hepat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b213b1a9e5c08726688d0b2915121e65
https://doi.org/10.1021/es903909g

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Kinetics of 8-2 fluorotelomer alcohol and its metabolites, and liver glutathione status following daily oral dosing for 45 days in male and female rats

Autor: Bogdan Szostek, Michael L. Gargas, Lisa M. Sweeney, Diane L. Nabb, William J. Fasano, Michael P. Mawn, Robert C. Buck

Publikováno v: Chemico-Biological Interactions. 180:281-295

Fluorotelomer alcohols (FTOHs) are raw materials used in the manufacture of polymeric and surfactant products. Based on previous findings from single oral dosing in rats with radiolabeled 8-2 FTOH, glutathione (GSH) depletion and/or the presence of p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88b0a41dbb7f3d31aceb5b1d72537418
https://doi.org/10.1016/j.cbi.2009.03.015

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Non-coplanar 2,2′,3,3′,4,4′,5,5′,6,6′-decachlorobiphenyl (PCB 209) did not induce cytochrome P450 enzyme activities in primary cultured rat hepatocytes, was not genotoxic, and did not exhibit endocrine-modulating activities

Autor: Diane L. Nabb, Robert T. Mingoia, Jane J. Clarke, John C. O'Connor, E. Maria Donner, Xing Han, Suzanne I. Snajdr, A. Michael Kaplan

Publikováno v: Toxicology. 255:177-186

2,2′,3,3′,4,4′,5,5′,6,6′-Decachlorobiphenyl (PCB 209) is a fully chlorinated, non-coplanar biphenyl. To demonstrate that PCB 209 is not likely to exhibit human health hazards common to coplanar PCBs it was tested for cytochrome P450 (P450)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963ade2b11a5757b5488ec587b302f2f
https://doi.org/10.1016/j.tox.2008.10.013

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In Vitro Metabolism of 8-2 Fluorotelomer Alcohol: Interspecies Comparisons and Metabolic Pathway Refinement

Autor: William J. Fasano, Matthew W. Himmelstein, Lisa M. Sweeney, Bogdan Szostek, Diane L. Nabb, Judith C. Stadler, Michael P. Mawn, Robert C. Buck, Michael L. Gargas

Publikováno v: Toxicological Sciences. 100:333-344

The detection of perfluorinated organic compounds in the environment has generated interest in their biological fate. 8-2 Fluorotelomer alcohol (8-2 FTOH, C(7)F(15)CF(2)CH(2)CH(2)OH), a raw material used in the manufacture of fluorotelomer-based prod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57e53d315a65a7c70a591806335cecd0
https://doi.org/10.1093/toxsci/kfm230

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Determination of Xenobiotic Intrinsic Clearance in Freshly Isolated Hepatocytes from Rainbow Trout (Oncorhynchus mykiss) and Rat and Its Application in Bioaccumulation Assessment

Autor: Robert T. Mingoia, Ching-Hui Yang, Diane L. Nabb, Xing Han

Publikováno v: Environmental Science & Technology. 41:3269-3276

Bioaccumulation in fish depends on the dynamics of various processes that involve fish uptake, storage, and elimination of xenobiotics. Elimination via fish biotransformation is a primary process that can be evaluated in an in vitro system to improve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c97d607c41d8c2da618e34a6fb50a8c
https://doi.org/10.1021/es0626279

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