Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Diane K, Wherrett"'
Autor:
Alyssa C. M. Joynt, Ashish R. Deshwar, Jessica Zon, Lucie Dupuis, Diane K. Wherrett, Roberto Mendoza‐Londono
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
Abstract Background Unbalanced translocations between the q arm of chromosomes 5 and 13 are exceedingly rare and there is only one reported case with distal trisomy 5q/monosomy 13q. In this report, we describe a second patient with a similar rearrang
Externí odkaz:
https://doaj.org/article/1cbe99f8c96c431e9902bb75e780f41a
Autor:
Rachel E. J. Besser, Kirstine J. Bell, Jenny J. Couper, Anette‐G. Ziegler, Diane K. Wherrett, Mikael Knip, Cate Speake, Kristina Casteels, Kimberly A. Driscoll, Laura Jacobsen, Maria E. Craig, Michael J. Haller
Publikováno v:
Pediatr. Diabetes 23, 1175-1187 (2022)
Autor:
Kevan C. Herold, Anette-Gabriele Ziegler, Darrell M. Wilson, Diane K. Wherrett, John M Wentworth, Jay S. Skyler, Phillip Raskin, Andrew B. Muir, Antoinette M. Moran, Wayne V Moore, Daniel J. Moore, Sandra M. Lord, S. Alice Long, Peter S. Linsley, Ingrid M. Libman, Jeffrey P Krischer, Michael J. Haller, Carla J. Greenbaum, Peter A. Gottlieb, Robin S. Goland, Stephen E. Gitelman, Laura A. Cooney, Mark S. Anderson, Brian N. Bundy, William E. Russell
Objective Previous studies showed that inhibiting lymphocyte costimulation reduces declining beta cell function in individuals newly-diagnosed with type 1 diabetes. We tested whether abatacept would delay or prevent progression of type 1 diabetes fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e612bbc18c514cf7dd93b604e719af2d
https://doi.org/10.2337/figshare.22009586
https://doi.org/10.2337/figshare.22009586
Autor:
LAURA M. JACOBSEN, DAVID D. CUTHBERTSON, MICHAEL J. HALLER, HEBA M. ISMAIL, EMILY K. SIMS, STEPHEN E. GITELMAN, DIANE K. WHERRETT, ANTOINETTE MORAN, MARK A. ATKINSON, ALBERTO PUGLIESE, PETER GOTTLIEB, JAY SOSENKO
Publikováno v:
Diabetes. 71
C-peptide area under the curve (AUC) at ≥1 year, a standard endpoint of recent-onset T1D clinical trials, is derived from a 120-minute mixed meal tolerance test (MMTT) . We analyzed whether composite glucose and C-peptide endpoints, useful in post
Autor:
Robert Stein, Sarah Lawrence, David S Saleh, Ereny Bassilious, Pranesh Chakraborty, Diane K. Wherrett, Alexa Marr, Ken Tang, Nicole Yokubynas
Publikováno v:
Paediatrics Publications
Context The apparent increased incidence of congenital hypothyroidism (CH) is partly due to increased detection of transient disease. Objective This work aims to identify predictors of transient CH (T-CH) and establish a predictive tool for its earli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb021e07ee956bed25e29378ac141a33
https://ir.lib.uwo.ca/paedpub/2685
https://ir.lib.uwo.ca/paedpub/2685
Autor:
Iria Gomez-Tourino, Bart O. Roep, Timothy Tree, Caroline M. Hull, Anna Lorenc, Emily Hanton, Sefina Arif, Mark Peakman, Daisy Melandri, Yogesh Kamra, Irma Pujol-Autonell, Craig A. Beam, Diane K. Wherrett
Publikováno v:
Diabetologia
Aims/hypothesis Antigen-specific therapy aims to modify inflammatory T cell responses in type 1 diabetes and restore immune tolerance. One strategy employs GAD65 conjugated to aluminium hydroxide (GAD-alum) to take advantage of the T helper (Th)2-bia
Autor:
Della Matheson, Lisa E. Rafkin, Helena Elding Larsson, Linda A. DiMeglio, Jeffrey P. Krischer, David Boulware, Mark A. Atkinson, Ingrid Libman, Maria Spall, Laura M. Jacobsen, Carla J. Greenbaum, Emily K. Sims, Susan Geyer, Diane K. Wherrett, Suzanne Bennett Johnson, Henry Rodriguez
Publikováno v:
Diabetes Care
OBJECTIVE To better understand potential facilitators of individual engagement in type 1 diabetes natural history and prevention studies through analysis of enrollment data in the TrialNet Pathway to Prevention (PTP) study. RESEARCH DESIGN AND METHOD
Autor:
Lucie Dupuis, Roberto Mendoza-Londono, Alyssa C. M. Joynt, Jessica Zon, Ashish R. Deshwar, Diane K. Wherrett
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 9, Iss 11, Pp n/a-n/a (2021)
Molecular Genetics & Genomic Medicine
Molecular Genetics & Genomic Medicine
Background Unbalanced translocations between the q arm of chromosomes 5 and 13 are exceedingly rare and there is only one reported case with distal trisomy 5q/monosomy 13q. In this report, we describe a second patient with a similar rearrangement ari
Autor:
Diane K. Wherrett
Publikováno v:
Diabetes Care
Prevention of type 1 diabetes has been brought closer to reality through the ability to identify populations at increased risk and through therapies that can modify the disease course (1). Identification of those who are at risk is based on the detec
Autor:
Kevan C, Herold, Brian N, Bundy, S Alice, Long, Jeffrey A, Bluestone, Linda A, DiMeglio, Matthew J, Dufort, Stephen E, Gitelman, Peter A, Gottlieb, Jeffrey P, Krischer, Peter S, Linsley, Jennifer B, Marks, Wayne, Moore, Antoinette, Moran, Henry, Rodriguez, William E, Russell, Desmond, Schatz, Jay S, Skyler, Eva, Tsalikian, Diane K, Wherrett, Anette-Gabriele, Ziegler, Carla J, Greenbaum, Stuart, Weinzimer
Publikováno v:
The New England journal of medicine, vol 381, iss 7
BackgroundType 1 diabetes is a chronic autoimmune disease that leads to destruction of insulin-producing beta cells and dependence on exogenous insulin for survival. Some interventions have delayed the loss of insulin production in patients with type