Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Diane J Lees-Murdock"'
Autor:
Charlotte E Rutledge, Ho-Tak Lau, Hazel Mangan, Linda L Hardy, Olaf Sunnotel, Fan Guo, Angus M MacNicol, Colum P Walsh, Diane J Lees-Murdock
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e88385 (2014)
Regulation of DNMT1 is critical for epigenetic control of many genes and for genome stability. Using phylogenetic analysis we characterized a block of 27 nucleotides in the 3'UTR of Dnmt1 mRNA identical between humans and Xenopus and investigated the
Externí odkaz:
https://doaj.org/article/ded1e919582a401c89d9eaa7a96e6861
Autor:
Aoife Caffrey, Helene McNulty, Mark Rollins, Girijesh Prasad, Pramod Gaur, Joel B. Talcott, Caroline Witton, Tony Cassidy, Barry Marshall, James Dornan, Adrian J. Moore, Mary Ward, J. J. Strain, Anne M. Molloy, Marian McLaughlin, Diane J. Lees-Murdock, Colum P. Walsh, Kristina Pentieva
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. We aimed to evaluate
Externí odkaz:
https://doaj.org/article/e9b336ae4aad4830b4f574eff95fbd3e
Autor:
Jennifer Deane, Helene McNulty, Mary Ward, A. McMahon, Diane J. Lees-Murdock, Sophia D. Amenyah, Geraldine Horigan, Colum P. Walsh, Catherine F Hughes, J. J. Strain, John Purvis
Publikováno v:
International Journal of Cardiology. 322:233-239
Background The interaction between genetic, epigenetic and environmental factors plays an important role in the aetiology of hypertension. GWAS and observational studies link the C677T polymorphism in methylenetetrahydrofolate reductase (MTHFR) with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c77342ee89bb02c83e40a69cf9e9a3f2
https://doi.org/10.1016/j.ijcard.2020.09.011
https://doi.org/10.1016/j.ijcard.2020.09.011
Autor:
Helene McNulty, Colum P. Walsh, Mary Ward, A. McMahon, Catherine F Hughes, Sophia D. Amenyah, J. J. Strain, Diane J. Lees-Murdock, John Purvis, Geraldine Horigan, Jennifer Deane
Publikováno v:
Biochimie. 173:17-26
DNA methylation is important in regulating gene expression and genomic stability while aberrant DNA methylation is associated with disease. Riboflavin (FAD) is a cofactor for methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea9676b3d6fc0494f15331e916b4c46d
https://doi.org/10.1016/j.biochi.2020.04.007
https://doi.org/10.1016/j.biochi.2020.04.007
Autor:
Miroslava Ondičová, Rachelle E. Irwin, Sara-Jayne Thursby, Luke Hilman, Aoife Caffrey, Tony Cassidy, Marian McLaughlin, Diane J. Lees-Murdock, Mary Ward, Michelle Murphy, Yvonne Lamers, Kristina Pentieva, Helene McNulty, Colum P. Walsh
Background We previously showed that continued folic acid (FA) supplementation beyond the first trimester of pregnancy appears to have beneficial effects on neurocognitive performance in children followed for up to 11 years, but the biological mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d031713bd6cee005aace65e16ee593f5
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476265
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-476265
Autor:
Tony Cassidy, Caroline Witton, Joel B. Talcott, Aoife Caffrey, Marian McLaughlin, Girijesh Prasad, Adrian Moore, Anne M. Molloy, Mark Rollins, Barry Marshall, Mary Ward, Pramod Gaur, J. J. Strain, Colum P. Walsh, Helene McNulty, Kristina Pentieva, Diane J. Lees-Murdock, James Dornan
Publikováno v:
BMC Medicine
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Background Maternal folic acid (FA) supplementation before and in early pregnancy prevents neural tube defects (NTD), but it is uncertain whether continuing FA after the first trimester has benefits on offspring health. We aimed to evaluate the effec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff4a6ac4a3700ca645b1b1d39eededd5
https://publications.aston.ac.uk/id/eprint/42427/1/s12916_021_01914_9.pdf
https://publications.aston.ac.uk/id/eprint/42427/1/s12916_021_01914_9.pdf
Autor:
John Purvis, Mary Ward, Colum P. Walsh, Catherine F Hughes, A. McMahon, Sophia D. Amenyah, Geraldine Horigan, J. J. Strain, Diane J. Lees-Murdock, Helene McNulty, Jennifer Deane
Publikováno v:
Proceedings of the Nutrition Society. 79
Introduction:The C677T polymorphism in the folate metabolising enzyme methylenetetrahydrofolate reductase (MTHFR) is associated with hypertension. Riboflavin acts as a cofactor for MTHFR in one-carbon metabolism which generates methyl groups for util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72f2ac04ddbe389d42896cbf02ef8157
https://doi.org/10.1017/s0029665120001858
https://doi.org/10.1017/s0029665120001858
Autor:
Rachelle E Irwin, Joel B. Talcott, Helene McNulty, Caroline Witton, Marian McLaughlin, Girijesh Prasad, Anthony Cassidy, Pramod Gaur, Diane J. Lees-Murdock, Colum P. Walsh, Aoife Caffrey, Kristina Pentieva
Publikováno v:
Proceedings of the Nutrition Society. 79
Periconceptional folic acid (FA) has an established role in the prevention of neural tube defects (NTDs), leading to global recommendations for FA supplementation before and in early pregnancy. However, it is unclear whether there are any benefits fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ab920328e20ff385c021703c2772f3d8
https://doi.org/10.1017/s0029665120004553
https://doi.org/10.1017/s0029665120004553
Autor:
Rachelle E Irwin, Colum P. Walsh, Diane J. Lees-Murdock, Mary Ward, Breige A. McNulty, Helene McNulty, Kristina Pentieva, Aoife Caffrey, James J. Strain
Publikováno v:
The American Journal of Clinical Nutrition. 107:566-575
Background Emerging evidence suggests that maternal folate status can impact cognitive development in childhood. Folate-dependent DNA methylation may provide a biological mechanism to link folate status during pregnancy with cognition in the offsprin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9e80846175abfd7914ac1854193c5f
https://doi.org/10.1093/ajcn/nqx069
https://doi.org/10.1093/ajcn/nqx069
Autor:
Kristina Pentieva, Lesley‐Anne Henry, Diane J. Lees-Murdock, Colum P. Walsh, Marian McLaughlin, Helene McNulty, Tony Cassidy
Publikováno v:
Acta Paediatrica. 107:1370-1378
AIM To test the effect of folic acid supplements taken throughout pregnancy on children's psychosocial development. METHOD A randomised controlled trial of folic acid supplementation in pregnancy, with parental rating using the Resiliency Attitudes a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c49437d9a3cf29c9abc878c9390a48c7
https://doi.org/10.1111/apa.14290
https://doi.org/10.1111/apa.14290