Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Diane Hudman"'
Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K channels during metabolic stress
Publikováno v:
Journal of Molecular and Cellular Cardiology. 39:637-646
ATP-sensitive K + (K A T P ) channels are involved in ischemic cardioprotection induced by preconditioning (IPC), though the relative role of sarcolemmal (sK A T P ) and mitochondrial (mitoK A T P ) channels remains controversial. The sK A T P -selec
Autor:
Diane Hudman, N. B. Standen
Publikováno v:
Journal of Molecular and Cellular Cardiology. 37:579-591
The protective effects of the PKC activator Phorbol 12-myristate 13-acetate (PMA) were investigated in electrically field stimulated (EFS) rat isolated ventricular myocytes following 7 min of metabolic inhibition induced by cyanide, iodoacetic acid a
Autor:
Noel W. Davies, Robert I. Norman, Richard D. Rainbow, N. B. Standen, Diane Hudman, David Lodwick
Publikováno v:
The Journal of Physiology. 557:785-794
C-terminal fragments of the sulphonylurea receptor SUR2A can alter the functional expression of cloned ATP-sensitive K(+) channels (K(ATP)). To investigate the protective role of K(ATP) channels during metabolic stress we transfected SUR2A fragments
Autor:
Robert I. Norman, Mark W Sims, Robert Jackson, Manish Patel, David Lodwick, Diane Hudman, Sean Brennan, Richard D. Rainbow
Publikováno v:
Journal of molecular and cellular cardiology. 79
ATP-sensitive potassium (KATP) channels are abundantly expressed in the myocardium. Although a definitive role for the channel remains elusive they have been implicated in the phenomenon of cardioprotection, but the precise mechanism is unclear. We s
Publikováno v:
Journal of Autonomic Pharmacology. 20:229-236
1. The aim of this study was to investigate the effect of in vitro and in vivo disopyramide treatment on human and rat isolated detrusor muscle contractile response. Muscle strips were suspended in an organ bath chamber containing Kreb's solution at
Publikováno v:
European Journal of Pharmacology. 397:169-176
We propose that ATP-sensitive K(+) (K(ATP)) channels are normally inactive but involved in beta(2)-adrenoceptor stimulated relaxation of the rat bladder. Spontaneous detrusor muscle contractions were unaffected by glibenclamide (K(ATP) channel blocke
Publikováno v:
European Journal of Pharmacology. 392:79-85
The action of clenbuterol, beta(2)-adrenoceptor agonist, on the contractile response of isolated rat detrusor muscle strips was investigated in vitro. Clenbuterol (10(-5) M) inhibited the detrusor muscle frequency response (1-40 Hz, p
Autor:
Kenneth L. Rinehart, Klaus Carstensen, Cornelis J. P. Grimmelikhuijzen, Diane Hudman, Ian D. McFARLANE, Furong Sun
Publikováno v:
Peptides. 14:131-135
Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide) we have isolated the neuropeptide
Autor:
Mohammed Al Johi, Ian Ashmole, Harprit Singh, David Lodwick, Marian James, Robert I. Norman, Diane Hudman, Peter J. Watson, Noel W. Davies, Richard D. Rainbow
Functional KATP (ATP-sensitive potassium) channels are hetero-octamers of four Kir6 (inwardly rectifying potassium) channel subunits and four SUR (sulphonylurea receptor) subunits. Possible interactions between the C-terminal domain of SUR2A and Kir6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac791dd2b026e99d0f0affbd4d3e3a5d
http://hdl.handle.net/2086/10959
http://hdl.handle.net/2086/10959
Autor:
Robert I. Norman, Richard D. Rainbow, Diane Hudman, Harprit Singh, C.L. Lawrence, David Lodwick
Publikováno v:
Journal of molecular and cellular cardiology. 35(5)
The subcellular distribution of ATP-sensitive potassium (K(ATP)) channel subunits in rat-isolated ventricular myocytes was investigated using a panel of subunit-specific antisera. Kir6.1 subunits were associated predominantly with myofibril structure