Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Diane H. Moon"'
Autor:
Mudit Chaand, Chris Fiore, Brian Johnston, Anthony D’Ippolito, Diane H. Moon, John P. Carulli, Jeffrey R. Shearstone
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Human genetics has validated de-repression of fetal gamma globin (HBG) in adult erythroblasts as a powerful therapeutic paradigm in diseases involving defective adult beta globin (HBB)1. To identify factors involved in the switch from HBG to
Externí odkaz:
https://doaj.org/article/b3930ed08ff74686802ee60965e48080
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
An important feature of the memory system is the ability to forget, but aging is associated with declines in the ability to intentionally forget potentially due to declines in cognitive control. Despite cognitive deficits, older adults are sensitive
Externí odkaz:
https://doaj.org/article/9def8744fac14861ac313c3994e7787a
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2acb90770440e5c75527fdef4c7d6307
https://doi.org/10.2139/ssrn.4017441
https://doi.org/10.2139/ssrn.4017441
Autor:
Patrick Cahan, Diane H. Moon, Suneet Agarwal, Maud Z. Muosieyiri, Asli Aykanat, Albert K. Tai, Matthew Segal, Baris Boyraz
Publikováno v:
Journal of Clinical Investigation. 126:3377-3382
The telomerase RNA component (TERC) is a critical determinant of cellular self-renewal. Poly(A)-specific ribonuclease (PARN) is required for posttranscriptional maturation of TERC. PARN mutations lead to incomplete 3' end processing and increased des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c059ccbb351db343ff64436165a840b7
https://doi.org/10.1172/jci87547
https://doi.org/10.1172/jci87547
Autor:
Sioban Keel, Suneet Agarwal, Neha Nagpal, Yick W. Fong, R. Coleman Lindsley, Scot A. Wolfe, Patrick Cahan, Jianing Wang, Emily K.W. Lo, Diane H. Moon, Albert K. Tai, Roman Othmar Braun, Daniel E. Bauer, Kevin Luk, Christopher R. Reilly, Lauri Burroughs, Jing Zeng
Publikováno v:
Cell Stem Cell. 26:896-909.e8
Summary Genetic lesions that reduce telomerase activity inhibit stem cell replication and cause a range of incurable diseases, including dyskeratosis congenita (DC) and pulmonary fibrosis (PF). Modalities to restore telomerase in stem cells throughou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83b0e0673a12d6e83ec6975a0618b542
https://doi.org/10.1016/j.stem.2020.03.016
https://doi.org/10.1016/j.stem.2020.03.016
Autor:
Eva C. Guinan, Patrick Cahan, Diane H. Moon, Matthew Segal, Albert K. Tai, Suneet Agarwal, Inga Hofmann, Baris Boyraz
Publikováno v:
Nature Genetics. 47:1482-1488
Mutations in the PARN gene (encoding poly(A)-specific ribonuclease) cause telomere diseases including familial idiopathic pulmonary fibrosis (IPF) and dyskeratosis congenita(1,2), but how PARN deficiency impairs telomere maintenance is unclear. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36964092712a4185dbc99cd86383c9d
https://doi.org/10.1038/ng.3423
https://doi.org/10.1038/ng.3423
Autor:
John P. Carulli, Brian T Johnston, Mudit Chaand, Diane H Moon, Chris Fiore, Jeffrey R. Shearstone
Publikováno v:
Blood. 134:812-812
Human beta-like globin gene expression is developmentally regulated. Erythroblasts (EBs) derived from fetal tissues, such as umbilical cord blood (CB), primarily express gamma globin mRNA (HBG) and HbF, while EBs derived from adult tissues, such as b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34d85d0d32bed7aaf203371c4641e97f
https://doi.org/10.1182/blood-2019-124337
https://doi.org/10.1182/blood-2019-124337