Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Diane Gong"'
Autor:
Andrew Jenkins, Ken Solt, R. Adron Harris, Edmond I. Eger, James R. Trudell, Diane Gong, Ingrid A. Lobo
Publikováno v:
Anesthesia & Analgesia. 107:486-493
BACKGROUND:The purpose of this study was to determine whether pairs of compounds, including general anesthetics, could simultaneously modulate receptor function in a synergistic manner, thus demonstrating the existence of multiple intraprotein anesth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87a1401a796f1bd451bd41354adc71be
https://doi.org/10.1213/ane.0b013e31817b70c1
https://doi.org/10.1213/ane.0b013e31817b70c1
Autor:
Gary Peltz, James M. Sonner, Edmond I. Eger, Saunak Sen, Yilei Xing, Michael J. Cascio, Diane Gong, John Popovich
Publikováno v:
Anesthesia & Analgesia. 105:381-385
The minimum alveolar concentration (MAC) of isoflurane is a quantitative trait because it varies continuously in a population. The location on the genome of genes or other genetic elements controlling quantiative traits is called quantitative trait l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fb69a07e63c307fce3d4dd160070e70
https://doi.org/10.1213/01.ane.0000261277.65343.4e
https://doi.org/10.1213/01.ane.0000261277.65343.4e
Autor:
Edmond I. Eger, Bharat Keshavaprasad, Robert J Brosnan, Joseph F. Cotten, Diane Gong, James M. Sonner, C. Spencer Yost
Publikováno v:
Anesthesia & Analgesia. 103:86-91
Chirality has been proposed as a means for distinguishing relevant from irrelevant molecular targets of action, but the sensitivity and specificity of this test is unknown for volatile anesthetics. We applied enantiomers of two chiral anesthetic alco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1070bd7e84864e3a20b75d07d7413413
https://doi.org/10.1213/01.ane.0000221437.87338.af
https://doi.org/10.1213/01.ane.0000221437.87338.af
Autor:
Anya J. Maurer, Diane Gong, Nicole V. Baron, Edmond I. Eger, Michael S. Fanselow, James M. Sonner, Bryce Vissel, Gordon Royle, Neil L. Harrison
Publikováno v:
Anesthesia & Analgesia. 101:143-148
Combinations of GluR5-GluR7, KA1, and KA2 subunits form kainate receptors, a subtype of excitatory ionotropic glutamate receptors. Isoflurane enhances the action of kainate receptors comprising GluR6 subunits expressed in oocytes. To test whether alt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32585ddea9d4c7ae6c7c202f7572c9b2
https://doi.org/10.1213/01.ane.0000152615.53435.b4
https://doi.org/10.1213/01.ane.0000152615.53435.b4
Publikováno v:
Anesthesiology. 97:902-905
Background Neuronal nicotinic acetylcholine receptors (nAChRs) have been implicated in the mechanism of action of isoflurane as they are inhibited at subanesthetic concentrations. Despite clear evidence for nicotinic inhibition at relevant isoflurane
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9902f042dcbf3f66260fe1a1bf91e3
https://doi.org/10.1097/00000542-200210000-00023
https://doi.org/10.1097/00000542-200210000-00023
Publikováno v:
Anesthesia & Analgesia. 94:1028-1033
UNLABELLED Malignant hyperthermia (MH) is an autosomal dominant, potentially fatal pharmacogenetic disorder of skeletal muscle. Approximately half of all known MH families show a linkage to the ryanodine receptor type 1 (RY1) gene. Although our knowl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0786bb5e33c0118adc6a1b46e6581407
https://doi.org/10.1097/00000539-200204000-00048
https://doi.org/10.1097/00000539-200204000-00048
Autor:
Robert C. Dutton, S. John Mihic, Edmond I. Eger, R. Adron Harris, Yi Zhang, James R. Trudell, James M. Sonner, Caroline R. Stabernack, Tomohiro Yamakura, Diane Gong
Publikováno v:
Anesthesia & Analgesia. 93:1246-1252
UNLABELLED: The in vivo potencies of anesthetics correlate with their capacity to suppress the reaction of luciferin with luciferase. In addition, luciferin has structural resemblances to etomidate. These observations raise the issues of whether luci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b5c9997018fcf608c0fb5cb5601151
https://doi.org/10.1097/00000539-200111000-00041
https://doi.org/10.1097/00000539-200111000-00041
Autor:
Beverley A. Orser, John F. MacDonald, Daisy T. Joo, James M. Sonner, Edmond I. Eger, Diane Gong, Zhengping Jia
Publikováno v:
Anesthesiology. 94:478-488
Background The alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptor mediates fast excitatory neurotransmission in the central nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae159cd5c66b98c4f4e9fd925b761d0c
https://doi.org/10.1097/00000542-200103000-00020
https://doi.org/10.1097/00000542-200103000-00020
Autor:
Edmond I. Eger, Pompiliu Ionescu, Donald D. Koblin, Michael J. Halsey, Tomas Hudlicky, Diane Gong, Michael J. Laster
Publikováno v:
Anesthesia & Analgesia. 88:1161-1167
The several potent inhaled anesthetics released for clinical use in the past four decades have been halogenated ethers, and, with one exception, methyl ethyl ethers.In the present report, we detail some structural and physical properties associated w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c681d806b5b7937f017c8cc2f405b810
https://doi.org/10.1097/00000539-199905000-00036
https://doi.org/10.1097/00000539-199905000-00036
Autor:
Michael J. Laster, Donald D. Koblin, Diane Gong, Edmond I. Eger, Pompiliu Ionescu, James M. Sonner, Tomas Hudlicky, Michael J. Halsey
Publikováno v:
Anesthesia & Analgesia. 88:884-892
UNLABELLED Some inhaled compounds cause convulsions. To better appreciate the physical basis for this property, we correlated the partial pressures that produced convulsions in rats with the lipophilicity (nonpolarity) and hydrophilicity (polarity) o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3acf4581d808fef21068f64d80d6b63b
https://doi.org/10.1097/00000539-199904000-00037
https://doi.org/10.1097/00000539-199904000-00037