Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Diane Gesty-Palmer"'
Autor:
Louis M Luttrell, Moahad S Dar, Diane Gesty-Palmer, Hesham M El-Shewy, Katherine M Robinson, Courtney J Haycraft, Jeremy L Barth
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0204197 (2019)
Bone remodeling involves the coordinated actions of osteoclasts, which resorb the calcified bony matrix, and osteoblasts, which refill erosion pits created by osteoclasts to restore skeletal integrity and adapt to changes in mechanical load. Osteobla
Externí odkaz:
https://doaj.org/article/a2dcf0467f014bbbb7d264e131ad3d2b
Autor:
Benny J Chen, Divino Deoliveira, Ivan Spasojevic, Gregory D Sempowski, Chen Jiang, Kouros Owzar, Xiaojuan Wang, Diane Gesty-Palmer, J Mark Cline, J Daniel Bourland, Greg Dugan, Sarah K Meadows, Pamela Daher, Garrett Muramoto, John P Chute, Nelson J Chao
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11056 (2010)
Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. BALB/c mice were irradiated
Externí odkaz:
https://doaj.org/article/d9e27d221d674827a1bcbca260eccf08
Autor:
Darren K. McGuire, Mark O'Neill, Frank Mikell, Anne L. Peters, Claire Baker, Phillip Banks, Diane Gesty‐Palmer, Suman Wason, Thomas Danne, Sangeeta Sawhney, Paul Strumph, Anna Chang, Jake A. Kushner
Publikováno v:
Diabetes, Obesity & Metabolism
Aims To assess the dose‐related effects of sotagliflozin, a novel dual inhibitor of sodium‐glucose co‐transporters‐1 and ‐2, in type 1 diabetes (T1D). Materials and methods In this 12‐week, multicentre, randomized, double‐blind, placebo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e569d763c211bd8fce1076a7a1ad43ea
https://doi.org/10.1111/dom.13825
https://doi.org/10.1111/dom.13825
Autor:
Diane Gesty-Palmer, Yarlagadda S. Babu, Cynthia Parker, David Reynolds, Xilin Chen, Matthew G. Davidson, Melanie Cornpropst, William P. Sheridan, Stuart Mair, Amanda Mathis
Publikováno v:
Blood. 136:15-16
INTRODUCTION: Complement factor D is the rate-limiting enzyme for activation of the complement alternative pathway (AP). Targeting factor D is therefore an attractive therapeutic strategy for treatment of AP-mediated diseases including paroxysmal noc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef83d7229f85602cb364a57c4c2ab353
https://doi.org/10.1182/blood-2020-138475
https://doi.org/10.1182/blood-2020-138475
Autor:
Antonio M. Risitano, Austin G. Kulasekararaj, Xilin Chen, Matthew G. Davidson, Diane Gesty-Palmer, Kristin Tower, Phil Collis, Andrew M. McDonald, Melanie Cornpropst, Jacques Le Roux Malherbe, William P. Sheridan
Publikováno v:
Blood. 136:14-15
INTRODUCTION: PNH, a rare, chronic, life-threatening disease, is characterized by hemolytic anemia due to uncontrolled activity of the complement alternative pathway (AP), bone marrow failure, and thrombosis. Inhibition of C5 by intravenously adminis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::105f9509e8ea61a59d0c2e82a23117f1
https://doi.org/10.1182/blood-2020-138838
https://doi.org/10.1182/blood-2020-138838
Autor:
Phillip Banks, Sangeeta Sawhney, Darren K. McGuire, Diane Gesty‐Palmer, Anna Chang, Thomas Danne, Anne L. Peters, Paul Strumph, Frank Mikell, Suman Wason, Jake A. Kushner, Mark O'Neill, Claire Baker
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc8e40298669686fcc87a38a7101dac
https://doi.org/10.1111/dom.13825/v2/response1
https://doi.org/10.1111/dom.13825/v2/response1
Autor:
Louis M. Luttrell, Carlos Nogueras-Ortiz, Diane Gesty-Palmer, Guillermo A. Yudowski, Mi-Hye Lee, Erik G. Strungs, Kathryn M. Appleton, Yuri K. Peterson
Publikováno v:
SSRN Electronic Journal.
While structurally distinct ligands can “bias” the efficiency with which G protein-coupled receptors (GPCRs) activate different downstream effectors, it is thought that the events downstream of a single effector are inseparable. We tested a panel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49732cd9021bddef3bc6be7652f68caa
https://doi.org/10.2139/ssrn.3422428
https://doi.org/10.2139/ssrn.3422428
Autor:
Moahad Dar, Louis M. Luttrell, Hesham M. El-Shewy, Diane Gesty-Palmer, Jeremy L. Barth, Katherine M. Robinson, Courtney J. Haycraft
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0204197 (2019)
PLoS ONE
PLoS ONE
Bone remodeling involves the coordinated actions of osteoclasts, which resorb the calcified bony matrix, and osteoblasts, which refill erosion pits created by osteoclasts to restore skeletal integrity and adapt to changes in mechanical load. Osteobla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc80c9daa6c3e01d525f779c56969b0d
https://doaj.org/article/a2dcf0467f014bbbb7d264e131ad3d2b
https://doaj.org/article/a2dcf0467f014bbbb7d264e131ad3d2b
Autor:
Pablo Lapuerta, Gregory R. Fulcher, Robert R. Henry, Darren K. McGuire, Satish K. Garg, Anne L. Peters, Rafael Simó, Diane Gesty‐Palmer, Paul Strumph, Thomas Danne, John B. Buse, Melanie J. Davies, Jake A. Kushner, Paolo Pozzilli, Phillip Banks
Publikováno v:
Diabetologie und Stoffwechsel.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61af87aea9c0813f8c44eb3c4a66ac74
https://doi.org/10.1055/s-0038-1641841
https://doi.org/10.1055/s-0038-1641841
Autor:
William H. Wood, Shamit Patel, Bronwen Martin, Kevin G. Becker, Yongqing Zhang, Calvin A. Johnson, Louis M. Luttrell, Elin Lehrmann, Stuart Maudsley, Huey Cheung, Diane Gesty-Palmer
Publikováno v:
Molecular pharmacology
Biased G protein-coupled receptor agonists engender a restricted repertoire of downstream events from their cognate receptors, permitting them to produce mixed agonist-antagonist effects in vivo. While this opens the possibility of novel therapeutics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e5a536a978bf3eafde2d0971026d10
https://doi.org/10.1124/mol.114.095224
https://doi.org/10.1124/mol.114.095224