Výsledky vyhledávání - "Diane G Kelley"

Akademický článek

Keratinocyte-targeted expression of human laminin γ2 rescues skin blistering and early lethality of laminin γ2 deficient mice.

Autor: Tracy L Adair-Kirk, Gail L Griffin, Michelle J Meyer, Diane G Kelley, Jeffrey H Miner, Douglas R Keene, M Peter Marinkovich, J Michael Ruppert, Jouni Uitto, Robert M Senior

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e45546 (2012)

Laminin-332 is a heterotrimeric basement membrane component comprised of the α3, ß3, and γ2 laminin chains. Laminin-332 modulates epithelial cell processes, such as adhesion, migration, and differentiation and is prominent in many embryonic and ad

Externí odkaz: https://doaj.org/article/0d0b7f25a524459b96d7840d807b0f76

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Aging Regulates Post-Viral Asthmatic Airway Pathology

Asthma is a common chronic disease of childhood, but for unknown reasons disease activity sometimes subsides as children mature. To understand why, we exposed mice across a range of ages to viral and allergic triggers of asthma exacerbations and airw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::58439c9f0ce3a2d38064135fdaeb1f9d
https://doi.org/10.21203/rs.3.rs-544240/v1

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GATA2 Regulates Constitutive PD-L1 and PD-L2 Expression in Brain Tumors

Autor: Jay A. Bowman-Kirigin, Yu Tao, Tanner M. Johanns, Jingqin Luo, Diane G. Kelley, Diane D. Mao, Maximilian Schaettler, Gavin P. Dunn, Connor J. Liu, Albert H. Kim, Ian F. Dunn, Wenya Linda Bi, Ravindra Uppaluri, Dale K. Kobayashi, Yujie Fu, Diane Bender

Publikováno v: Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)

Encouraging clinical results using immune checkpoint therapies to target the PD-1 axis in a variety of cancer types have paved the way for new immune therapy trials in brain tumor patients. However, the molecular mechanisms that regulate expression o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076e1fd25ede50b3aeddd7c214555bd6
http://europepmc.org/articles/PMC7271235

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The Role of Matrix Metalloproteinase-9 in Cigarette Smoke–induced Emphysema

Autor: Susan H. Conradi, Diane G. Kelley, Yoko Suzuki, Gaëtan Deslée, Jeffrey J. Atkinson, Carla Moore, Dale K. Kobayashi, Whitney G. Ijem, Richard A. Pierce, Barbara A. Lutey, Tomoko Betsuyaku, David S. Gierada, M. Eileen Jacobs, Holly M. Toennies, Robert M. Senior

Publikováno v: American Journal of Respiratory and Critical Care Medicine. 183:876-884

Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by activated macrophages that may be involved in the development of human pulmonary emphysema and could be inhibited with existing compounds. Mouse models have demonstrated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee6056f66f41c75690be81f09a3154ea
https://doi.org/10.1164/rccm.201005-0718oc

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Distal Airways in Mice Exposed to Cigarette Smoke

Autor: Gail L. Griffin, Jeffrey J. Atkinson, Daphne E. deMello, Robert M. Senior, Mark A. Watson, Tomoko Betsuyaku, Diane G. Kelley, Tracy L. Adair-Kirk

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 39:400-411

Cigarette smoke (CS) is the main risk factor for chronic obstructive pulmonary disease (COPD). Terminal bronchioles are critical zones in the pathophysiology of COPD, but little is known about the cellular and molecular changes that occur in cells li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad61a293a743dfc322ddeead06672030
https://doi.org/10.1165/rcmb.2007-0295oc

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Neutrophil Elastase Cleaves Laminin-332 (Laminin-5) Generating Peptides That Are Chemotactic for Neutrophils

Autor: Robert M. Senior, Thomas J. Broekelmann, Diane G. Kelley, J. Michael Shipley, Robert P. Mecham, Piotr Mydel, Tracy L. Adair-Kirk

Publikováno v: Journal of Biological Chemistry. 283:9513-9522

Proteolytic processing of laminin-332 by matrix metalloproteinase (MMP)-2 and MMP-14 has been shown to yield fragments that are promigratory for epithelial cells. During acute and chronic inflammation, proteases are elaborated by neutrophils and macr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8be0214c0fbb3c7bd46907ced39970f
https://doi.org/10.1074/jbc.m706239200

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Elastin fragments drive disease progression in a murine model of emphysema

Autor: David L. Perkins, Robert P. Mecham, Luiz A. Marconcini, Pablo A. Quintero, Steven D. Shapiro, Diane G. Kelley, Robert M. Senior, A. McGarry Houghton, Dale K. Kobayashi

Publikováno v: Journal of Clinical Investigation. 116:753-759

Mice lacking macrophage elastase (matrix metalloproteinase-12, or MMP-12) were previously shown to be protected from the development of cigarette smoke-induced emphysema and from the accumulation of lung macrophages normally induced by chronic exposu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f61cf5302175bbf3b43b829af3881137
https://doi.org/10.1172/jci25617

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