Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Diane G, Carnathan"'
Autor:
Christopher A. Cottrell, Payal P. Pratap, Kimberly M. Cirelli, Diane G. Carnathan, Chiamaka A. Enemuo, Aleksandar Antanasijevic, Gabriel Ozorowski, Leigh M. Sewall, Hongmei Gao, Joel D. Allen, Bartek Nogal, Murillo Silva, Jinal Bhiman, Matthias Pauthner, Darrell J. Irvine, David Montefiori, Max Crispin, Dennis R. Burton, Guido Silvestri, Shane Crotty, Andrew B. Ward
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract Immunodominance of antibodies targeting non-neutralizing epitopes and the high level of somatic hypermutation within germinal centers (GCs) required for most HIV broadly neutralizing antibodies (bnAbs) are major impediments to the developmen
Externí odkaz:
https://doaj.org/article/bdb802dbabe14d2b9e05554af9fa7556
Autor:
Ivy Phung, Kristen A. Rodrigues, Ester Marina-Zárate, Laura Maiorino, Bapi Pahar, Wen-Hsin Lee, Mariane Melo, Amitinder Kaur, Carolina Allers, Marissa Fahlberg, Brooke F. Grasperge, Jason P. Dufour, Faith Schiro, Pyone P. Aye, Paul G. Lopez, Jonathan L. Torres, Gabriel Ozorowski, Saman Eskandarzadeh, Michael Kubitz, Erik Georgeson, Bettina Groschel, Rebecca Nedellec, Michael Bick, Katarzyna Kaczmarek Michaels, Hongmei Gao, Xiaoying Shen, Diane G. Carnathan, Guido Silvestri, David C. Montefiori, Andrew B. Ward, Lars Hangartner, Ronald S. Veazey, Dennis R. Burton, William R. Schief, Darrell J. Irvine, Shane Crotty
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Adjuvants and antigen delivery kinetics can profoundly influence B cell responses and should be critically considered in rational vaccine design, particularly for difficult neutralizing antibody targets such as human immunodeficiency virus (
Externí odkaz:
https://doaj.org/article/3d71acce904648df957070b08d1daea9
Autor:
Sedem Dankwa, Christina Kosman, Maria Dennis, Elena E Giorgi, Kenneth Vuong, Ioanna Pahountis, Ashley Garza, Christian Binuya, Janice McCarthy, Bryan T Mayer, Julia T Ngo, Chiamaka A Enemuo, Diane G Carnathan, Sherry Stanfield-Oakley, Stella J Berendam, Carolyn Weinbaum, Kathleen Engelman, Diogo M Magnani, Cliburn Chan, Guido Ferrari, Guido Silvestri, Rama R Amara, Ann Chahroudi, Sallie R Permar, Genevieve G Fouda, Ria Goswami
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312411 (2024)
To eliminate vertical HIV transmission and achieve therapy-free viral suppression among children living with HIV, novel strategies beyond antiretroviral therapy (ART) are necessary. Our group previously identified a triple broadly neutralizing antibo
Externí odkaz:
https://doaj.org/article/67249a617a5941c98087a2a5528cf93f
Autor:
Tania Rivera-Hernandez, Diane G. Carnathan, Johanna Richter, Patrick Marchant, Amanda J. Cork, Gayathiri Elangovan, Anna Henningham, Jason N. Cole, Biswa Choudhury, Peter M. Moyle, Istvan Toth, Michael R. Batzloff, Michael F. Good, Paresh Agarwal, Neeraj Kapoor, Victor Nizet, Guido Silvestri, Mark J. Walker
Publikováno v:
Vaccines, Vol 12, Iss 4, p 382 (2024)
Vaccine development against group A Streptococcus (GAS) has gained traction in the last decade, fuelled by recognition of the significant worldwide burden of the disease. Several vaccine candidates are currently being evaluated in preclinical and ear
Externí odkaz:
https://doaj.org/article/f26816dbe57b4c9a970c04ef4ce18d98
Autor:
Aleksandar Antanasijevic, Leigh M. Sewall, Christopher A. Cottrell, Diane G. Carnathan, Luis E. Jimenez, Julia T. Ngo, Jennifer B. Silverman, Bettina Groschel, Erik Georgeson, Jinal Bhiman, Raiza Bastidas, Celia LaBranche, Joel D. Allen, Jeffrey Copps, Hailee R. Perrett, Kimmo Rantalainen, Fabien Cannac, Yuhe R. Yang, Alba Torrents de la Peña, Rebeca Froes Rocha, Zachary T. Berndsen, David Baker, Neil P. King, Rogier W. Sanders, John P. Moore, Shane Crotty, Max Crispin, David C. Montefiori, Dennis R. Burton, William R. Schief, Guido Silvestri, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Here, the authors present cryoEMPEM, a method for high-resolution structural analysis of vaccine-elicited polyclonal antibody responses. They apply cryoEMPEM in combination with standard serology experiments to characterize the polyclonal antibody (p
Externí odkaz:
https://doaj.org/article/04ab87746dbe4d4ea81ab039e453c3ac
Autor:
Michelle Y-H Lee, Amit A Upadhyay, Hasse Walum, Chi N Chan, Reem A Dawoud, Christine Grech, Justin L Harper, Kirti A Karunakaran, Sydney A Nelson, Ernestine A Mahar, Kyndal L Goss, Diane G Carnathan, Barbara Cervasi, Kiran Gill, Gregory K Tharp, Elizabeth R Wonderlich, Vijayakumar Velu, Simon M Barratt-Boyes, Mirko Paiardini, Guido Silvestri, Jacob D Estes, Steven E Bosinger
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009674 (2021)
HIV associated immune activation (IA) is associated with increased morbidity in people living with HIV (PLWH) on antiretroviral therapy, and remains a barrier for strategies aimed at reducing the HIV reservoir. The underlying mechanisms of IA have no
Externí odkaz:
https://doaj.org/article/23f45ec77beb4055b59259a74d913d13
Autor:
Tania Rivera-Hernandez, Diane G. Carnathan, Scott Jones, Amanda J. Cork, Mark R. Davies, Peter M. Moyle, Istvan Toth, Michael R. Batzloff, James McCarthy, Victor Nizet, David Goldblatt, Guido Silvestri, Mark J. Walker
Publikováno v:
mBio, Vol 11, Iss 6 (2020)
Externí odkaz:
https://doaj.org/article/fe4c5b4d42a34e9ca2fe812304c04d3f
Autor:
Maura Statzu, Wang Jin, Emily J. Fray, Andrew Kam Ho Wong, Mithra R. Kumar, Elizabeth Ferrer, Steffen S. Docken, Mykola Pinkevych, Julia B. McBrien, Christine M. Fennessey, Brandon F. Keele, Shan Liang, Justin L. Harper, Simona Mutascio, Lavinia Franchitti, Hong Wang, Davide Cicetti, Steven E. Bosinger, Diane G. Carnathan, Thomas H. Vanderford, David M. Margolis, J. Victor Garcia-Martinez, Ann Chahroudi, Mirko Paiardini, Janet Siliciano, Miles P. Davenport, Deanna A. Kulpa, Robert S. Siliciano, Guido Silvestri
Publikováno v:
Nature Microbiology. 8:299-308
Persistence of the human immunodeficiency virus type-1 (HIV-1) latent reservoir in infected individuals remains a problem despite fully suppressive antiretroviral therapy (ART). While reservoir formation begins during acute infection, the mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db10d5604fd58f1605a3ccd68b90084d
https://doi.org/10.1038/s41564-022-01311-9
https://doi.org/10.1038/s41564-022-01311-9
Autor:
Christopher A Cottrell, Jelle van Schooten, Charles A Bowman, Meng Yuan, David Oyen, Mia Shin, Robert Morpurgo, Patricia van der Woude, Mariëlle van Breemen, Jonathan L Torres, Raj Patel, Justin Gross, Leigh M Sewall, Jeffrey Copps, Gabriel Ozorowski, Bartek Nogal, Devin Sok, Eva G Rakasz, Celia Labranche, Vladimir Vigdorovich, Scott Christley, Diane G Carnathan, D Noah Sather, David Montefiori, Guido Silvestri, Dennis R Burton, John P Moore, Ian A Wilson, Rogier W Sanders, Andrew B Ward, Marit J van Gils
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008753 (2020)
The induction of broad and potent immunity by vaccines is the key focus of research efforts aimed at protecting against HIV-1 infection. Soluble native-like HIV-1 envelope glycoproteins have shown promise as vaccine candidates as they can induce pote
Externí odkaz:
https://doaj.org/article/72423643bd5d4a468b042d1e1469cde7
Autor:
Diane G. Carnathan, Kirti Kaushik, Ali H. Ellebedy, Chiamaka A. Enemuo, Etse H. Gebru, Pallavi Dhadvai, Mohammed Ata Ur Rasheed, Matthias G. Pauthner, Gabriel Ozorowski, Rafi Ahmed, Dennis R. Burton, Andrew B. Ward, Guido Silvestri, Shane Crotty, Michela Locci
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
T follicular helper (TFH) cells are powerful regulators of affinity matured long-lived plasma cells. Eliciting protective, long-lasting antibody responses to achieve persistent immunity is the goal of most successful vaccines. Thus, there is potentia
Externí odkaz:
https://doaj.org/article/6a342a2d376d40c9a622e807800f05fb