Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Diane F. Matesic"'
Publikováno v:
Current Topics in Medicinal Chemistry. 20:883-900
Cancer is a devastating disease that has plagued humans from ancient times to this day. After decades of slow research progress, promising drug development, and the identification of new targets, the war on cancer was launched, in 1972. The P13K/Akt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69992ed5d7f1c07ef5636eedfc1a68da
https://doi.org/10.2174/1568026620666200224101808
https://doi.org/10.2174/1568026620666200224101808
Publikováno v:
Anticancer Research. 39:5329-5338
Background/aim The P13K/Akt signaling pathway is a growth-regulating cellular pathway that is constitutively activated in a variety of human cancers. In previous studies, we reported that a solenopsin analog, compound B (MU-06-SC-608-7), shows inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d133497aa083c3afc5d49e8e7d37d40f
https://doi.org/10.21873/anticanres.13725
https://doi.org/10.21873/anticanres.13725
Publikováno v:
Investigational New Drugs. 37:902-911
Chaetoglobosin K (ChK) is a natural product that has been shown to promote F-actin capping, inhibit growth, arrest cell cycle G2 phase, and induce apoptosis. ChK also has been shown to downregulate two important kinases involved in oncogenic pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e478f6a4905ffa145a2c5f014495e930
https://doi.org/10.1007/s10637-018-0705-7
https://doi.org/10.1007/s10637-018-0705-7
Publikováno v:
Bioorganicmedicinal chemistry letters. 28(19)
The P13K/Akt pathway is a growth-regulating cellular signaling pathway that is over-activated in numerous human cancers. A novel series of Akt pathway inhibitors were identified using iterative pharmacophore modeling, energy-based calculations, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdfb066dca0592520939fb57c3ce704e
https://pubmed.ncbi.nlm.nih.gov/30143420
https://pubmed.ncbi.nlm.nih.gov/30143420
Publikováno v:
International Immunopharmacology. 21:44-50
The interactions between the immune and nervous systems play an important role in immune and inflammatory conditions. Substance P (SP), the undecapeptide RPKPQQFFGLM-NH 2 , is known to upregulate the production of pro-inflammatory cytokines such as t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0390c475484c675d53ea89dccc4897a
https://doi.org/10.1016/j.intimp.2014.04.007
https://doi.org/10.1016/j.intimp.2014.04.007
Publikováno v:
Current Bioactive Compounds. 9:255-262
Cell-cell communication through gap junctions is aberrant or absent in a majority of human cancer cells, compared to cells in corresponding normal tissues. This and other evidence has led to the hypothesis that gap junction channels, comprised of con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfdd4eec83139221285270d629e069a3
https://doi.org/10.2174/157340720903140119155322
https://doi.org/10.2174/157340720903140119155322
Publikováno v:
Investigational new drugs. 33(4)
4-Phenyl-3-butenoic acid (PBA) is an inhibitor of peptidylglycine alpha-amidating monooxygenase with anti-inflammatory properties that has been shown to inhibit the growth of ras-mutated epithelial and human lung carcinoma cells. In this report, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4323297cb4752d9ef5e9a3d95606c3dd
https://pubmed.ncbi.nlm.nih.gov/26065689
https://pubmed.ncbi.nlm.nih.gov/26065689
Publikováno v:
Anticancer research. 35(2)
4-phenyl-3-butenoic acid (PBA) is a small-molecule anti-inflammatory agent, which has been shown to inhibit growth, increase gap junction intercellular communication and modulate activation of p38 mitogen-activated protein kinase (p38 MAPK) and c-jun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b4ed366dfc0f4fc755307c0e7690e478
https://pubmed.ncbi.nlm.nih.gov/25667457
https://pubmed.ncbi.nlm.nih.gov/25667457
Autor:
Jeffrey D. Hugdahl, Erin L. Garcia, John D. Bauer, Horace G. Cutler, Diane F. Matesic, Stephen J. Cutler
Publikováno v:
Medicinal Chemistry Research. 14:369-381
9-O-methylfusarubin was isolated from a novel source, Fusarion oxysporum, and evaluated for its phytotoxic and chlorotic inducing properties in plants as well as its potential as an antineoplastic agent. Etiolated wheat coleptiles were inhibited 100
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9056437d6105e906c1dac9bc4c0a781
https://doi.org/10.1007/s00044-006-0145-3
https://doi.org/10.1007/s00044-006-0145-3
Publikováno v:
Molecular Carcinogenesis. 41:231-246
Recent studies have shown that the proliferation of some tumor cells is dependent on autocrine growth loops that require amidated autocrine growth factors. Peptidylglycine alpha-monooxygenase (PAM) is required for amidation of these growth factors an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f1776ad65a7327b079b8c55c57ac05
https://doi.org/10.1002/mc.20060
https://doi.org/10.1002/mc.20060