Výsledky vyhledávání - "Diane F. Hill"

TTF-1, a Homeodomain Gene Required for Diencephalic Morphogenesis, Is Postnatally Expressed in the Neuroendocrine Brain in a Developmentally Regulated and Cell-Specific Fashion

Autor: Maria E. Costa, Robert B. Norgren, Marie Pierre Junier, Gyeong Jae Cho, Diane F. Hill, Byung Ju Lee, Sergio R. Ojeda, Veronica Tapia

Publikováno v: Molecular and Cellular Neuroscience. 17:107-126

TTF-1 is a member of the Nkx family of homeodomain genes required for morphogenesis of the hypothalamus. Whether TTF-1, or other Nkx genes, contributes to regulating differentiated hypothalamic functions is not known. We now report that postnatal hyp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649763b170e26d3f6f3d6714565cdf9b
https://doi.org/10.1006/mcne.2000.0933

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Neuregulins Signaling via a Glial erbB-2–erbB-4 Receptor Complex Contribute to the Neuroendocrine Control of Mammalian Sexual Development

Autor: Anda Cornea, Maria E. Costa, Mario N. Lioubin, Gregory D. Plowman, Diane F. Hill, Sergio R. Ojeda, Kimberly E. Creswick, Ying J. Ma

Publikováno v: The Journal of Neuroscience. 19:9913-9927

Activation of erbB-1 receptors by glial TGFα has been shown to be a component of the developmental program by which the neuroendocrine brain controls mammalian sexual development. The participation of other members of the erbB family may be required

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d18ddd8b47a0f58e6457a435e86c574
https://doi.org/10.1523/jneurosci.19-22-09913.1999

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The Oct-2 POU Domain Gene in the Neuroendocrine Brain: A Transcriptional Regulator of Mammalian Puberty*

Autor: Jennifer W. Hill, Anda Cornea, Maria E. Costa, Diane F. Hill, Veronica Tapia, Sergio R. Ojeda, Ying J. Ma

Publikováno v: Endocrinology. 140:3774-3789

POU homeodomain genes are transcriptional regulators that control development of the mammalian forebrain. Although they are mostly active during embryonic life, some of them remain expressed in the postnatal hypothalamus, suggesting their involvement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc4e8792d4ed9b0339cefb2ed903892
https://doi.org/10.1210/endo.140.8.6941

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Targeting transforming growth factor α expression to discrete loci of the neuroendocrine brain induces female sexual precocity

Autor: Florence Rage, Xandra O. Breakefield, Samuel M. McCann, Diane F. Hill, Maria E. Costa, Sergio R. Ojeda, Miguel Sena-Esteves, Robert J. Coffey

Publikováno v: Proceedings of the National Academy of Sciences. 94:2735-2740

Precocious puberty of cerebral origin is a poorly understood disorder of human sexual development, brought about by the premature activation of those neurons that produce luteinizing hormone-releasing hormone (LHRH), the neuropeptide controlling sexu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f07116efe653aba0a5ec9b33b45b31f
https://doi.org/10.1073/pnas.94.6.2735

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Neural and glial-mediated effects of growth factors acting via tyrosine kinase receptors on luteinizing hormone-releasing hormone neurons

Autor: Nabil G. Seidah, Ying Jun Ma, W. H. Fahrenbach, K Berg-von der Emde, Maria E. Costa, William C. Wetsel, Diane F. Hill, P Voigt, K G Taylor, D Gonzalez, Sergio R. Ojeda

Publikováno v: Endocrinology. 137:2593-2605

It is becoming increasingly evident that the secretory activity of LHRH neurons is regulated not only by transsynaptic inputs but also by trophic molecules of glial and neuronal origin. The present experiments were undertaken to gain insights into th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::419cf69198d59b34dc864a75e5e7ac84
https://doi.org/10.1210/endo.137.6.8641214

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Basic fibroblast growth factor regulates the conversion of pro-luteinizing hormone-releasing hormone (Pro-LHRH) to LHRH in immortalized hypothalamic neurons

Autor: Sergio R. Ojeda, William C. Wetsel, Diane F. Hill

Publikováno v: Endocrinology. 137:2606-2616

Growth factors are commonly associated with the regulation of cellular proliferation and differentiation. In established cells, growth factors can also serve as trophic agents. Immortalized LHRH neurons contain basic fibroblast growth factor (bFGF) r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8125f4c93b0b625b9c2179faf364cdbf
https://doi.org/10.1210/endo.137.6.8641215

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The Gene Encoding Nerve Growth Factor Is Expressed in the Immature Rat Ovary: Effect of Denervation and Hormonal Treatment*

Autor: Kathy H. Katz, Hernan E. Lara, Sergio R. Ojeda, Diane F. Hill

Publikováno v: Endocrinology. 126:357-363

The rat ovary is innervated by sympathetic nerve fibers. Since the development and survival of peripheral sympathetic neurons innervating nonreproductive organs have been shown to depend on the production of nerve growth factor (NGF) by the innervate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59adfd2161cd57d70e8104b4e116b58
https://doi.org/10.1210/endo-126-1-357

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Intraovarian excess of nerve growth factor increases androgen secretion and disrupts estrous cyclicity in the rat

Autor: Victor Leyton, Maria E. Costa, Alberto Martínez-Serrano, Sergio R. Ojeda, Gregory A. Dissen, Hernan E. Lara, Alfonso Paredes, Diane F. Hill

Publikováno v: ENDOCRINOLOGY
Artículos CONICYT
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A single injection of estradiol valerate induces a form of cystic ovary resembling some aspects of the human polycystic ovarian syndrome. Preceding the development of follicular cysts, there is an increase in intraovarian synthesis of nerve growth fa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::615b3c1682d095872752d5686e365c23
https://pubmed.ncbi.nlm.nih.gov/10698183

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A role for trkA nerve growth factor receptors in mammalian ovulation

Autor: Gregory A. Dissen, Maria E. Costa, Hernan E. Lara, Diane F. Hill, Sergio R. Ojeda, W. Les Dees

Publikováno v: Endocrinology. 137(1)

Several members of the neurotrophin (NT) family, including nerve growth factor (NGF), NT-3, and NT-4/5, are expressed in the mammalian ovary. As their respective receptor tyrosine kinases are also found in the gland, the possibility exists that NTs a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce973db771793a902f62134573ad610
https://pubmed.ncbi.nlm.nih.gov/8536613

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