Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Diane F. Gerken"'
Autor:
Molly Vallant, Gary A. Boorman, Diane F. Gerken, Edward H. Lebetkin, Leo T. Burka, Irwin D. Richard, Pamela E. Blackshear, Joel S. Parker, Edward K. Lobenhofer
Publikováno v:
Toxicologic Pathology. 33:111-117
The liver is a common organ for transcriptional profiling because of its role in xenobiotic metabolism and because hepatotoxicity is a common response to chemical exposure. To explore the impact that sampling different lobes may have on transcription
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e321a4d4cc2aaa4b5de4d2e82cced4d5
https://doi.org/10.1080/01926230590522257
https://doi.org/10.1080/01926230590522257
Autor:
Randall L. Detra, Richard A. Sams, David S. Watt, Alwarsamy Jegananthan, Jyan Ming Yang, William E. Wood, Diane F. Gerken, Hsin Hsinng Tai, Thomas Tobin, Scott D Stanley
Publikováno v:
Journal of Pharmaceutical Sciences. 85:79-84
Two metabolites of the tranquilizer azaperone were extracted from alkalinized horse urine after treatment with beta-glucuronidase/sulfatase from limpets (Patella vulgata). The metabolites were identified by a combination of independent chemical synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77739b7d77af246e5290d2252918efff
https://doi.org/10.1021/js950205j
https://doi.org/10.1021/js950205j
Autor:
J. W. Blake, Scott D Stanley, Diane F. Gerken, David S. Watt, T. Wood, H H Tai, Thomas Tobin, Richard A. Sams, Stefan Kwiatkowski, P. Henry, W. E. Woods, J. P. Goodman, S.-L. Chang
Publikováno v:
Journal of Analytical Toxicology. 18:95-100
We have raised antibodies and developed one-step enzyme-linked immunosorbent assays (ELISA) for the diuretics ethacrynic acid and bumetanide as part of a panel of pre- and post-race tests for high potency drugs in racing horses. These ELISA tests are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83a0baad250cdb17385fadd2a614eac9
https://doi.org/10.1093/jat/18.2.95
https://doi.org/10.1093/jat/18.2.95
Autor:
Diane F. Gerken, Richard A. Sams
Publikováno v:
Veterinary Clinics of North America: Equine Practice. 9:461-479
Although all the factors discussed in this article may have an effect on drug withholding time estimates, the factors that have the potential for the greatest effect or that have been found to cause positive tests in the past are 1. Dosage: Increasin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a75f1dfdf9bdbab50a2d65976083004
https://doi.org/10.1016/s0749-0739(17)30380-2
https://doi.org/10.1016/s0749-0739(17)30380-2
Publikováno v:
Journal of analytical toxicology. 25(1)
A method for the simultaneous determination of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2-methyl-4-chlorophenoxyacetic acid (MCPA) in canine plasma and urine has been developed. This method used derivatization of extracted samples with 9-anthrylmet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7868d91c4e99a6b20be40c2981cc4b4d
https://pubmed.ncbi.nlm.nih.gov/11215998
https://pubmed.ncbi.nlm.nih.gov/11215998
Publikováno v:
Journal of toxicology. Clinical toxicology. 38(7)
To investigate the clinical effects and to determine the 2,4-dichlorophenoxyacetic acid plasma concentrations after a dose of twice the reported LD50 (100 mg/kg) was administered orally to dogs. Investigation included electromyographic evaluations an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a18694077beadeab0a55add852e70d7
https://pubmed.ncbi.nlm.nih.gov/11192461
https://pubmed.ncbi.nlm.nih.gov/11192461
Publikováno v:
Journal of analytical toxicology. 23(5)
The objectives of the study were to compare various methods to determine flunixin in test samples collected periodically from horses after intramuscular (IM) and intravenous (IV) dosing at the maximum recommended dosage and to document detection time
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28e10e2fc9a548834f62a4e17af1bba3
https://pubmed.ncbi.nlm.nih.gov/10488926
https://pubmed.ncbi.nlm.nih.gov/10488926
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 20(5)
Cimetidine was administered intravenously and by the intragastric route to six mares at a dose of 4.0 mg/kg of body weight (bw). Specific and sensitive high performance liquid chromatographic methods for the determination of cimetidine in horse plasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584aa73600e1fc1d07c11791a3b7723f
https://pubmed.ncbi.nlm.nih.gov/9350255
https://pubmed.ncbi.nlm.nih.gov/9350255
Publikováno v:
Journal of pharmaceutical and biomedical analysis. 15(5)
The respiratory stimulant prethcamide is a mixture of equal parts of crotethamide and cropropamide. A specific and sensitive gas chromatographic method for the determination of crotethamide and cropropamide in horse plasma and urine is described. Bot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c68647b233c2655f533bdf8e5c497e4a
https://pubmed.ncbi.nlm.nih.gov/9127276
https://pubmed.ncbi.nlm.nih.gov/9127276
Publikováno v:
Journal of veterinary pharmacology and therapeutics. 17(4)
The disposition of florfenicol after single intravenous and intramuscular doses of 20 mg of florfenicol/kg of body weight (b.w.) to feeder calves was investigated. Serum florfenicol concentrations were determined by a sensitive high performance liqui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7192d1aaae5fcf47622a1b6137c7b47d
https://pubmed.ncbi.nlm.nih.gov/7966543
https://pubmed.ncbi.nlm.nih.gov/7966543