Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Diane Etchison"'
Publikováno v:
Virology. 211:451-461
Poliovirus infection results in a number of host cell changes, including specific alterations in cellular proteins. This study further characterizes the cleavage of a cytoskeletal protein, microtubule-associated protein 4 (MAP-4) and investigates the
Publikováno v:
Journal of Virology. 65:3903-3905
Previously we demonstrated that echovirus 22 is an atypical enterovirus which does not shut off host cell protein synthesis. We extend these findings by showing that echovirus 22 does not cleave p220, part of the cellular cap-binding complex necessar
Publikováno v:
The Journal of biological chemistry. 267(32)
Eukaryotic protein synthesis initiation factor (eIF) 4 gamma, also known as p220, is a component of the protein complex eIF-4, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recrui
Publikováno v:
Scopus-Elsevier
Poliovirus infection of HeLa cells induces rapid shutoff of host protein synthesis, whereas translation of poliovirus RNA is not inhibited. It is presumed that shutoff is the result of proteolytic cleavage of component p220 of eucaryotic initiation f
Autor:
Ellie Ehrenfeld, Diane Etchison, S. Milburn, Isaac Edery, Nahum Sonenberg, J. Hansen, J. W. B. Hershey
Publikováno v:
Journal of Virology. 51:832-837
Protein synthesis initiation factor preparations from poliovirus-infected HeLa cells have reduced ability to initiate translation on capped mRNA. The defect in initiation factors has been variously attributed to inactivation of eucaryotic initiation
Publikováno v:
Virology. 150:299-303
Poliovirus protein 2A contains a short amino acid sequence that also occurs in the putative active site of the known viral proteinase, 3C, previously shown to be responsible for glutamine/glycine cleavages in the poliovirus polyprotein precursor. Exp
Publikováno v:
Molecular and Cellular Biology. 2:1639-1643
The 26,000-Mrcap-binding protein was analyzed by a cross-linking assay in cell fractions from uninfected and poliovirus-infected HeLa cells. Cap-binding protein was found in the postribosomal supernatant (S-200) and in the ribosomal salt wash. The ca
Publikováno v:
Journal of virology. 42(1)
Extracts from poliovirus-infected HeLa cells are unable to translate vesicular stomatitis virus or cellular mRNAs in vitro, probably reflecting the poliovirus-induced inhibition of host cell protein synthesis which occurs in vivo. Crude initiation fa
Autor:
Diane Etchison, Susan C. Milburn
Publikováno v:
Molecular and Cellular Biochemistry. 76
A cap binding complex activity was purified from HeLa cells by a procedure which does not depend on the use of cap-affinity chromatography. The activity co-purified with a Mr 220,000 polypeptide (p220), but not with eIF4A. The active complex therefor
Autor:
Diane Etchison, Shay Fout
Publikováno v:
Journal of virology. 54(2)
One of the characteristics of picornavirus infection of cells in tissue culture is a specific inhibition of utilization of host cell mRNA for protein synthesis. In this study we show that human rhinovirus 14 is similar to poliovirus in that the inhib