Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Diane E Merry"'
Autor:
David R. Garcia Castro, Joseph R. Mazuk, Erin M. Heine, Daniel Simpson, R. Seth Pinches, Caroline Lozzi, Kathryn Hoffman, Phillip Morrin, Dylan Mathis, Maria V. Lebedev, Elyse Nissley, Kang Hoo Han, Tyler Farmer, Diane E. Merry, Qiang Tong, Maria Pennuto, Heather L. Montie
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107375- (2023)
Summary: Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease with substantial mitochondrial and metabolic dysfunctions. SBMA is caused by polyglutamine (polyQ) expansion in the androgen receptor (AR). Activating or increasing the NAD
Externí odkaz:
https://doaj.org/article/0ad1fa7b373a453e989aeb3538dcebdf
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Spinal and bulbar muscular atrophy (SBMA) is an X-linked, neuromuscular neurodegenerative disease for which there is no cure. The disease is characterized by a selective decrease in fast-muscle power (e.g., tongue pressure, grip strength) ac
Externí odkaz:
https://doaj.org/article/852d8a96ae0245d89a211cfeaae39d6f
Autor:
Jordyn Karliner, Diane E. Merry
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101993- (2023)
Summary: Although PC12 cells are a valuable tool in neuroscience research, previously published PC12 cell differentiation techniques fail to consider the variability in differentiation rates between different PC12 cell strains and clonal variants. He
Externí odkaz:
https://doaj.org/article/5bc651c0cb60408889d4518473fe733f
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 15 (2022)
Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative and neuromuscular genetic disease caused by the expansion of a polyglutamine-encoding CAG tract in the androgen receptor (AR) gene. The AR is an important transcriptional regulator of t
Externí odkaz:
https://doaj.org/article/0d09c08ce9ca495fa0c06acb91e13d35
Autor:
Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert Wessells, Diane E. Merry, Sokol V. Todi
Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit theandrogen receptor(AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1da1501ee34d7c620baba69723cabb8
https://doi.org/10.1101/2023.03.25.534140
https://doi.org/10.1101/2023.03.25.534140
Autor:
Lori Zboray, Anna Pluciennik, Dana Curtis, Yuhong Liu, Lisa D. Berman-Booty, Christopher Orr, Cristina T. Kesler, Tamar Berger, Daniel Gioeli, Bryce M. Paschal, Diane E. Merry
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2312-2323 (2015)
Spinal and bulbar muscular atrophy (SBMA) is a neurodegenerative disease caused by a polyglutamine expansion in the androgen receptor (AR) and is associated with misfolding and aggregation of the mutant AR. We investigated the role of an interdomain
Externí odkaz:
https://doaj.org/article/4d4278aca62a481587b2fa6bdfef8cb4
Autor:
Jill M. Yersak, Heather L. Montie, Erica S. Chevalier-Larsen, Yuhong Liu, Lan Huang, Martin Rechsteiner, Diane E. Merry
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 10 (2017)
Spinal and bulbar muscular atrophy (SBMA) is caused by expression of a polyglutamine (polyQ)-expanded androgen receptor (AR). The inefficient nuclear proteasomal degradation of the mutant AR results in the formation of nuclear inclusions containing a
Externí odkaz:
https://doaj.org/article/5608ab2922dc4a428aed3541a9eef86c
Autor:
Jordyn Karliner, Diane E. Merry
Publikováno v:
STAR protocols. 4(1)
Although PC12 cells are a valuable tool in neuroscience research, previously published PC12 cell differentiation techniques fail to consider the variability in differentiation rates between different PC12 cell strains and clonal variants. Here, we pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af2f6ee524670f46a860b18263ec6e11
https://pubmed.ncbi.nlm.nih.gov/36602900
https://pubmed.ncbi.nlm.nih.gov/36602900
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 1, Pp 141-145 (2012)
SUMMARY Evidence from multiple animal models demonstrates that testosterone plays a crucial role in the progression of symptoms in spinal and bulbar muscular atrophy (SBMA), a condition that results in neurodegeneration and muscle atrophy in affected
Externí odkaz:
https://doaj.org/article/61eb42a48fed4434812641e06af451cf
Autor:
Frederick J. Arnold, Diane E. Merry
Publikováno v:
Neurotherapeutics
Spinal and bulbar muscular atrophy (SBMA) is a neuromuscular disease caused by a polyglutamine (polyQ) expansion in the androgen receptor (AR). Despite the fact that the monogenic cause of SBMA has been known for nearly 3 decades, there is no effecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed1e53e5f88bac95ce93a5448c049fd
http://europepmc.org/articles/PMC6985201
http://europepmc.org/articles/PMC6985201