Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Diane E Lucente"'
Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models
Autor:
M Catarina Silva, Fleur M Ferguson, Quan Cai, Katherine A Donovan, Ghata Nandi, Debasis Patnaik, Tinghu Zhang, Hai-Tsang Huang, Diane E Lucente, Bradford C Dickerson, Timothy J Mitchison, Eric S Fischer, Nathanael S Gray, Stephen J Haggarty
Publikováno v:
eLife, Vol 8 (2019)
Tauopathies are neurodegenerative diseases characterized by aberrant forms of tau protein accumulation leading to neuronal death in focal brain areas. Positron emission tomography (PET) tracers that bind to pathological tau are used in diagnosis, but
Externí odkaz:
https://doaj.org/article/61644ae2e0484e5e9ce5e832e02c1ee1
Autor:
Ping-Chieh Pao, Jinsoo Seo, Audrey Lee, Oleg Kritskiy, Debasis Patnaik, Jay Penney, Ravikiran M. Raju, Ute Geigenmuller, M. Catarina Silva, Diane E. Lucente, James F. Gusella, Bradford C. Dickerson, Anjanet Loon, Margaret X. Yu, Michael Bula, Melody Yu, Stephen J. Haggarty, Li-Huei Tsai
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product p25, leading to prolonged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f59bcb292e1d1b5c3991d1c46aa356d
https://doi.org/10.1073/pnas.2217864120
https://doi.org/10.1073/pnas.2217864120
Autor:
Julio C. Rojas, Hilary W. Heuer, Weiping Chen, Julie Czerkowicz, Danielle Graham, Leah K. Forsberg, Danielle Brushaber, Brian Appleby, Eliana Marisa Ramos, Giovanni Coppolla, Yvette M. Bordelon, Hugo Botha, Brad C. Dickerson, Dennis W. Dickson, Kimiko Domoto‐Reilly, Anne M. Fagan, Julie A. Fields, Jamie C. Fong, Tatiana M. Foroud, Doug R. Galasko, Ralitza H. Gavrilova, Daniel H. Geschwind, Nupur Ghoshal, Jill Goldman, Neill R. Graff‐Radford, Jonathan Graff‐Radford, Ian Grant, Murray Grossman, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward D. Huey, David J. Irwin, David T. Jones, Kejal Kantarci, David S. Knopman, John Kornak, Walter K. Kremers, Maria I. Lapid, Gabriel C. Leger, Irene Litvan, Peter A. Ljubenkov, Diane E. Lucente, Ian R Mackenzie, Joseph C. Masdeu, Corey T. McMillan, Mario F. Mendez, Bruce L. Miller, Toji Miyagawa, Chiadi U. Onyike, Belen Pascual, Otto Pedraza, Leonard Petrucelli, Rosa Rademakers, Katherine P. Rankin, Katya Rascovsky, Jessica E. Rexach, Aaron Ritter, Erik D. Roberson, Rodolfo Savica, William W. Seeley, Adam M. Staffaroni, Maria Carmela Tartaglia, Arthur W. Toga, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Lawren Vandevrede, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9ba5ff64ac03f24ac019cbc56adec4c
https://doi.org/10.1002/alz.052993
https://doi.org/10.1002/alz.052993
Autor:
Julio C. Rojas, Lawren Vandevrede, Hilary W. Heuer, Gianina Toller, Elisabeth H. Thijssen, Nicholas Proctor, Leah K. Forsberg, Danielle Brushaber, Eliana Marisa Ramos, Giovanni Coppola, Brian Appleby, Yvette M. Bordelon, Hugo Botha, Brad C. Dickerson, Dennis W. Dickson, Kimiko Domoto‐Reilly, Anne M. Fagan, Julie A. Fields, Jamie C. Fong, Tatiana M. Foroud, Doug R. Galasko, Ralitza H. Gavrilova, Daniel H. Geschwind, Nupur Ghoshal, Jill Goldman, Neill R. Graff‐Radford, Jonathan Graff‐Radford, Ian Grant, Murray Grossman, Ging‐Yuek Robin Hsiung, Eric J. Huang, Edward D. Huey, David J. Irwin, David T. Jones, Kejal Kantarci, David S. Knopman, John Kornak, Walter K. Kremers, Maria I. Lapid, Gabriel C. Leger, Irene Litvan, Peter A. Ljubenkov, Diane E. Lucente, Ian R. Mackenzie, Joseph C. Masdeu, Corey T. McMillan, Mario Mendez, Bruce L. Miller, Toji Miyagawa, Chiadi U. Onyike, Belen Pascual, Otto Pedraza, Leonard Petrucelli, Rosa Rademakers, Katherine P. Rankin, Katya Rascovsky, Jessica E. Rexach, Aaron Ritter, Erik D. Roberson, Rodolfo Savica, William W. Seeley, Adam M. Staffaroni, Maria Carmela Trataglia, Arthur W. Toga, Sandra Weintraub, Bonnie Wong, Zbigniew Wszolek, Jeffrey L. Dage, Bradley F. Boeve, Howard J. Rosen, Adam L. Boxer
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fc26c5630e6585daa65c282a7eae88fc
https://doi.org/10.1002/alz.055763
https://doi.org/10.1002/alz.055763