Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Diane C. Hoffman"'
Autor:
Mulugeta Million, Jing-Fang Zhao, Andrew Luckey, József Czimmer, George D Maynard, John Kehne, Diane C Hoffman, Yvette Taché
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73749 (2013)
Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases. We investigated the inhibito
Externí odkaz:
https://doaj.org/article/803ea8aaa29b44e9b54bec8f43f6b2fd
Autor:
Diane C. Hoffman, Thomas A. Pitler, Terrance H. Andree, Matthew J. Hansard, Lance A. Smith, John H. Kehne, Gary Paul Stack, Peter Jenner, Michael J. Jackson, Mark R. Hurtt
Publikováno v:
Journal of Neural Transmission. 117:55-67
Dopamine replacement therapy in Parkinson's disease (PD) using L-dopa is invariably associated with a loss of drug efficacy ("wearing off") and the onset of dyskinesia. The use of dopamine receptor partial agonists might improve therapeutic benefit w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dedc9eb56c06a270cb9560d3b1181e6
https://doi.org/10.1007/s00702-009-0323-9
https://doi.org/10.1007/s00702-009-0323-9
Autor:
Xiao-Shu He, Andrew Thurkauf, Andrzej Kieltyka, Jan W. F. Wasley, Robbin Brodbeck, He Zhao, Diane C. Hoffman, Renee J. Primus
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 12:3111-3115
A series of chiral benzylpiperazinyl-1-(2,3-dihydro-indol-1-yl)ethanone derivatives were prepared and examined for their affinity at dopamine D2 and D4 receptors. Three compounds having D2/D4 affinity ratios approximating that found for the atypical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5e0fd275bd4e4a19ae2bd12af99f435
https://doi.org/10.1016/s0960-894x(02)00656-x
https://doi.org/10.1016/s0960-894x(02)00656-x
Autor:
Maria D. Bacolod, Andrew Thurkauf, Xiaoyan Zhang, Andrzej Kieltyka, Jennifer Tran, Jan W. F. Wasley, He Zhao, Robbin Brodbeck, Brian Girard, Kevin J. Hodgetts, Diane C. Hoffman, Kimberly Craven, Stanislaw Rachwal
Publikováno v:
Journal of Medicinal Chemistry. 43:3923-3932
The dopaminergic receptor profile of a series of trans-1-[(2-phenylcyclopropyl)methyl]-4-arylpiperazines was examined. Aromatic substitution patterns were varied with the goal of identifying a compound having affinities for the D(2) and D(4) receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69ebbd3228b62f4930f7bbde7a791a72
https://doi.org/10.1021/jm990562x
https://doi.org/10.1021/jm990562x
Publikováno v:
Neuropharmacology. 39:1357-1367
CRF(1) receptor antagonists have been proposed as novel pharmacological treatments for depression, anxiety and stress disorders. The primary goal of the present study was to evaluate the effects of the CRF(1) receptor antagonist, CP 154,526, in the s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e4907f7b84959731eda171d1c16ce6
https://doi.org/10.1016/s0028-3908(00)00043-5
https://doi.org/10.1016/s0028-3908(00)00043-5
Autor:
Hilary Donovan, Diane C. Hoffman
Publikováno v:
Drug Development Research. 36:193-198
Because amphetamine-induced place conditioning is believed to be mediated by dopamine (DA) receptors within the nucleus accumbens, this behavioral model may be useful for detecting drugs with antipsychotic efficacy. To test the selectivity and specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d54275f1d896930d9806b24519ff7bd
https://doi.org/10.1002/ddr.430360406
https://doi.org/10.1002/ddr.430360406
Autor:
Diane C. Hoffman
Publikováno v:
Pharmacology Biochemistry and Behavior. 47:907-912
The noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 prevents the development of sensitization to the locomotor-activating effects of amphetamine. In the present study, the possibility that the NMDA receptor might also play a rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e829c3a6e14d07af5b6d6213376e4a
https://doi.org/10.1016/0091-3057(94)90295-x
https://doi.org/10.1016/0091-3057(94)90295-x
Autor:
Diane C. Hoffman, Roy A. Wise
Publikováno v:
Psychopharmacology. 110:402-408
Rats were given daily injections of bromocriptine (5.0 mg/kg IP) or vehicle either in the home cage or in a test box equipped with photocells to measure locomotion. The animals were then tested in the photocell boxes for their locomotor response to c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a431d2f289a701c5f1242e1bf7017803
https://doi.org/10.1007/bf02244645
https://doi.org/10.1007/bf02244645
Autor:
Xi Chen, Hilary Donovan, Andrew Thurkauf, Hutchison Alan J, Jan W. F. Wasley, Kristine Woodruff, Xiao Shu He, Robin Meade, Jun Yuan, Deborah K. Jones-Hertzog, Diane C. Hoffman
Publikováno v:
Journal of Medicinal Chemistry. 40:1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d220223d6cb8a83abc5e1e55957a0381
https://doi.org/10.1021/jm960637m
https://doi.org/10.1021/jm960637m
Autor:
Hilary Donovan, Diane C. Hoffman
Publikováno v:
Psychopharmacology. 115(4)
The amplitude of the acoustic startle response is decreased if the startle stimulus is preceded by a nonstartle eliciting stimulus. This sensorimotor gating phenomenon, known as prepulse inhibition, is diminished in schizophrenic individuals. In rats
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb992b1b14a57841bce7349f71df9617
https://pubmed.ncbi.nlm.nih.gov/7871088
https://pubmed.ncbi.nlm.nih.gov/7871088