Treatment algorithm and prognostic factors for patients with stage I–III carcinoma of the anal canal: a 20-year multicenter study

Autor: Jean-Baptiste Delhorme, Franck Monnien, Michael Herfs, Laurent Martin, Lucine Vuitton, Laurence Dusserre, Celia Reynders, Jean-François Bosset, Pascale Hubert, Prudence Colpart, Anne-Sophie Woronoff, Agnès Leroux, Patrick Roncarati, Philippe Delvenne, Laurent Arnould, Elodie Hendrick, Christiane Mougin, Marie Ancion, Didier Peiffert, Alexis Lepinoy, Jean-Luc Prétet, Olivier Peulen, Alexandra Luquain, Thomas Lerho, Diane Bruyère, Séverine Valmary-Degano, Charlotte Pilard, Chloé Molimard, Marie-Christine Bone-Lepinoy, Philippe Maingon, Jean-Pierre Ghnassia

Publikováno v: Modern Pathology
Modern Pathology, Nature Publishing Group: Open Access Hybrid Model Option B, 2021, 34 (1), pp.116-130. ⟨10.1038/s41379-020-0637-6⟩

Despite a growing incidence in developed countries and a recent improved understanding of its pathogenesis, anal cancer management has not evolved over the past decades and drug combination used as first-line regimen still largely depends on clinicia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a166aad4c870b9381fa15cb6094031fc
https://hal-univ-fcomte.archives-ouvertes.fr/hal-03169755

A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine

Autor: Philippe Delvenne, Frédéric Lambert, Nathalie Piazzon, Séverine Valmary-Degano, Elodie Hendrick, Vincent Bours, Aurélie Poncin, Jean-Luc Prétet, Christiane Mougin, Lucine Vuitton, Karin Segers, Olivier Peulen, David Guenat, Patrick Roncarati, Franck Monnien, Benjamin Koopmansch, Diane Bruyère, Pascale Hubert, Laurence de Leval, William Penny, Michael Herfs, Alizée Lebeau, Christopher P. Crum, Charles M. Quick

Publikováno v: British Journal of Cancer
British journal of cancer, vol. 118, no. 10, pp. 1302-1312

Background Primary adenocarcinoma of the anal canal is a rare and aggressive gastrointestinal disease with unclear pathogenesis. Because of its rarity, no clear clinical practice guideline has been defined and a targeted therapeutic armamentarium has

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::727b845e13b0a296918d858027e98dab
http://europepmc.org/articles/PMC5959925

Cervical Carcinogenesis, Early Detection and Prevention

Autor: Kyle Devins, M. Carolina Reyes, Alizée Lebeau, Diane Bruyère, Michael Herfs, Sharon Song

Publikováno v: Gynecologic and Obstetric Pathology, Volume 1 ISBN: 9789811330155

Cervical carcinoma is a major cause of morbidity and mortality in the United States and throughout the world. Associated to the infection with one or several high-risk human papillomavirus (HPV) genotypes, the incidence of cervical cancer increases p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::23ea3c16228c623e6fbcd1f97e6398d6
https://doi.org/10.1007/978-981-13-3016-2_11

HPV infection alters vaginal microbiome through down-regulating host mucosal innate peptides used by Lactobacilli as amino acid sources

Autor: Alizee Lebeau, Diane Bruyere, Patrick Roncarati, Paul Peixoto, Eric Hervouet, Gael Cobraiville, Bernard Taminiau, Murielle Masson, Carmen Gallego, Gabriel Mazzucchelli, Nicolas Smargiasso, Maximilien Fleron, Dominique Baiwir, Elodie Hendrick, Charlotte Pilard, Thomas Lerho, Celia Reynders, Marie Ancion, Roland Greimers, Jean-Claude Twizere, Georges Daube, Geraldine Schlecht-Louf, Françoise Bachelerie, Jean-Damien Combes, Pierrette Melin, Marianne Fillet, Philippe Delvenne, Pascale Hubert, Michael Herfs

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)

Here, the authors show that HPV infection leads to downregulation of host mucosal innate peptides, which are in turn used by predominant Lactobacillus species as amino acid source, promoting ultimately an imbalance in the vaginal flora.

Externí odkaz: https://doaj.org/article/521ef97d899041439a6f7558c5e56b61