Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Diane Corey"'
Autor:
Karthik Lingineni, Varun Aggarwal, Juan Francisco Morales, Daniela J. Conrado, Diane Corey, Camille Vong, Jackson Burton, Jane Larkindale, Klaus Romero, Stephan Schmidt, Sarah Kim, the Cooperative International Neuromuscular Research Group investigators and Duchenne Regulatory Science Consortium members
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 3, Pp 318-332 (2022)
Abstract Early clinical trials of therapies to treat Duchenne muscular dystrophy (DMD), a fatal genetic X‐linked pediatric disease, have been designed based on the limited understanding of natural disease progression and variability in clinical mea
Externí odkaz:
https://doaj.org/article/9a5c7e29fe9d4a999c3b88d80d68d01e
Autor:
Ariana P. Mullin, Diane Corey, Emily C. Turner, Richard Liwski, Daniel Olson, Jackson Burton, Sudhir Sivakumaran, Lynn D. Hudson, Klaus Romero, Diane T. Stephenson, Jane Larkindale
Publikováno v:
Clinical and Translational Science, Vol 14, Iss 1, Pp 214-221 (2021)
Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history
Externí odkaz:
https://doaj.org/article/040f5d647bf1412f9332d9664f2c5e5e
Autor:
Jane Larkindale, Emily C. Turner, Lynn D. Hudson, Diane Stephenson, Sudhir Sivakumaran, Ariana P. Mullin, Klaus Romero, Daniel Olson, Diane Corey, Richard Liwski, Jackson Burton
Publikováno v:
Clinical and Translational Science
Clinical and Translational Science, Vol 14, Iss 1, Pp 214-221 (2021)
Clinical and Translational Science, Vol 14, Iss 1, Pp 214-221 (2021)
Interest in drug development for rare diseases has expanded dramatically since the Orphan Drug Act was passed in 1983, with 40% of new drug approvals in 2019 targeting orphan indications. However, limited quantitative understanding of natural history
Autor:
Karthik, Lingineni, Varun, Aggarwal, Juan Francisco, Morales, Daniela J, Conrado, Diane, Corey, Camille, Vong, Jackson, Burton, Jane, Larkindale, Klaus, Romero, Stephan, Schmidt, Sarah, Kim, Emily, Carifi
Publikováno v:
CPT: pharmacometricssystems pharmacology. 11(3)
Early clinical trials of therapies to treat Duchenne muscular dystrophy (DMD), a fatal genetic X-linked pediatric disease, have been designed based on the limited understanding of natural disease progression and variability in clinical measures over
Autor:
Jason P. Block, Tiffany Powell-Wiley, Jane J. Lee, Karen Mutalik, Caroline S. Fox, Rebecca Joyce, Diane Corey, Shih-Jen Hwang
Publikováno v:
Obesity Science & Practice. 3:333-341
OBJECTIVE This study examined the cross-sectional and longitudinal relationships of built environment characteristics with adiposity and glycaemic measures. METHOD Longitudinal study sample consisted of 4,010 Framingham Heart Study Offspring (baselin
Autor:
Christine E. Seidman, Joel N. Hirschhorn, Martin G. Larson, Jonathan G. Seidman, Hiroyuki Morita, Emelia J. Benjamin, Daniel Levy, Scott Barr, Christopher J. O'Donnell, Diane Corey, Ramachandran S. Vasan
Publikováno v:
Circulation. 113:2697-2705
Background— Mutations in sarcomere protein, PRKAG2 , LAMP2 , α-galactosidase A ( GLA ), and several mitochondrial genes can cause rare familial cardiomyopathies, but their contribution to increased left ventricular wall thickness (LVWT) in the com
Autor:
Peter W.F. Wilson, Daniel Levy, Joanne M. Murabito, Martin G. Larson, Sekar Kathiresan, Richard P. Lifton, Gesa Ricken, Ramachandran S. Vasan, Emelia J. Benjamin, Diane Corey, James B. Meigs, Nader Rifai, Caroline S. Fox
Publikováno v:
American Journal of Hypertension. 18:657-665
Background We investigated the environmental and genetic sources of interindividual variability in serum aldosterone level in a large, community-based sample. Methods We examined the relation of serum aldosterone to vascular risk factors, urine sodiu
Autor:
Emelia J. Benjamin, Martin G. Larson, Ralph B. D'Agostino, Diane Corey, Christopher Newton-Cheh, Daniel Levy, Alan Herbert, Christopher J. O'Donnell
Publikováno v:
Heart Rhythm. 2:277-284
Objectives To identify genomic regions linked to QT interval duration in an unselected population. Background QT interval prolongation is associated with increased risk of sudden cardiac death and coronary heart disease and may result from acquired c
Autor:
Anita L. DeStefano, Diane Corey, Martin G. Larson, Ramachandran S. Vasan, Jiang Li, Gary F. Mitchell, Daniel Levy, Emelia J. Benjamin
Publikováno v:
Hypertension. 44:152-155
The objective of this study was to assess heritability and identify chromosomal regions showing evidence of linkage to pulse pressure (PP), a simple indicator of proximal conduit vessel stiffness. Blood pressure data were analyzed for 8478 members of
Autor:
Daniel Levy, Christopher J. O'Donnell, Martin G. Larson, Diane Corey, Hisako Tsuji, Jagmeet P. Singh
Publikováno v:
The American Journal of Cardiology. 90:1290-1293
There is a substantial heritable component to the beat-to-beat variation in heart rate. However, the molecular mechanisms underlying the control of heart rate variability (HRV) remain unknown. The present study sought to identify chromosomal regions