Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Diane, Ethier"'
Autor:
Diane Ethier
Les relations internationales sont les rapports multiformes entretenus par les individus, les organisations privées et les gouvernements dans les diverses sphères de l'activité humaine. Cet ouvrage s'attarde strictement aux relations politiques et
Autor:
Diane Ethier
The breakdown of authoritarian regimes in Greece, Spain and Portugal in the mid-70s was the beginning of a new cycle of democratization at the world scale. The 1980s have seen the emergence of formal, constitutional democracies in many countries, esp
Autor:
Diane Ethier
Publikováno v:
41:313-339
Depuis 1945, l’imposition de la démocratie par des forces étrangères a-t-elle été limitée à cinq cas d’exception, comme le prétend Schmitter, ou a-t-elle été à l’origine des deux tiers des démocraties comme le soutient Whitehead ? C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e850f230465762dbcf0224c2160060
https://doi.org/10.7202/044904ar
https://doi.org/10.7202/044904ar
Autor:
Richard Frenette, Jocelyne Guay, Christine Brideau, Evelyn Martins, Marc Gagnon, Denis Riendeau, Joseph A. Mancini, Andre Giroux, Bernard Cote, Louise Boulet, David Claveau, Diane Ethier, Frédéric Massé, Richard Friesen, Daigen Xu, Anh Chau, Nathalie Méthot, Joel Rubin, Yves Ducharme, Hongping Yu, Sébastien Guiral
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5837-5841
Phenanthrene imidazoles 26 and 44 have been identified as novel potent, selective and orally active mPGES-1 inhibitors. These inhibitors are significantly more potent than the previously reported chlorophenanthrene imidazole 1 (MF63) with a human who
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::211648f4f7f71bac98c75cfd8336367c
https://doi.org/10.1016/j.bmcl.2009.08.085
https://doi.org/10.1016/j.bmcl.2009.08.085
Autor:
Daniel, Guay, Christian, Beaulieu, Jean-Francois, Truchon, T, Jagadeeswar Reddy, Robert, Zamboni, Christopher I, Bayly, Nathalie, Methot, Joel, Rubin, Diane, Ethier, M, David Percival
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:5392-5396
A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702879c311550b3992e5b7e0c01b8bc2
https://doi.org/10.1016/j.bmcl.2009.07.114
https://doi.org/10.1016/j.bmcl.2009.07.114
Autor:
M. David Percival, Denis Normandin, Karen Ortega, Joel Rubin, Nathalie Méthot, Diane Ethier, T. Jagadeeswar Reddy, Denis Riendeau, Simon Wong, Daniel Guay, Christian Beaulieu
Publikováno v:
Molecular Pharmacology. 73:1857-1865
Inhibition of cathepsin C, a dipeptidyl peptidase that activates many serine proteases, represents an attractive therapeutic strategy for inflammatory diseases with a high neutrophil burden. We recently showed the feasibility of blocking the activati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b3d96663c517f65c9a67131bfbfe1f
https://doi.org/10.1124/mol.108.045682
https://doi.org/10.1124/mol.108.045682
Autor:
Diane Ethier
Publikováno v:
Canadian Journal of Political Science. 39:803-825
Résumé.Certains travaux indiquent qu'en matière de promotion de la démocratie, la conditionnalité des élargissements de l'Union européenne (UE) vers l'Europe du Sud et de l'Est s'est avérée plus efficace que les incitatifs employés par dive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5eb00927cd811b8c2c2f81f2a516f6a6
https://doi.org/10.1017/s000842390606029x
https://doi.org/10.1017/s000842390606029x
Autor:
Dwight Macdonald, Anthony Mastracchio, Hélène Perrier, Daniel Dubé, Michel Gallant, Patrick Lacombe, Denis Deschênes, Bruno Roy, John Scheigetz, Kevin Bateman, Chun Li, Laird A. Trimble, Stephen Day, Nathalie Chauret, Deborah A. Nicoll-Griffith, Jose M. Silva, Zheng Huang, France Laliberté, Susana Liu, Diane Ethier, Doug Pon, Eric Muise, Louise Boulet, Chi Chung Chan, Angela Styhler, Stella Charleson, Joseph Mancini, Paul Masson, David Claveau, Donald Nicholson, Mervyn Turner, Robert N. Young, Yves Girard
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:5241-5246
The discovery and SAR of a new series of substituted 8-arylquinoline PDE4 inhibitors are herein described. This work has led to the identification of several compounds with excellent in vitro and in vivo profiles, including a good therapeutic window
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff58af67854878403c87410ee5934af1
https://doi.org/10.1016/j.bmcl.2005.08.036
https://doi.org/10.1016/j.bmcl.2005.08.036
Autor:
Joel Rubin, Erich L. Grimm, Joseph A. Mancini, Richard Friesen, Diane Ethier, Denis Riendeau, Nathalie Méthot, Renee Aspiotis, Jocelyne Guay, Helene Juteau, Sébastien Guiral, Yves Gareau
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:3352-3355
A series of potent and selective inhibitors of the inducible microsomal PGE2 synthase (mPGES-1) has been developed based on the indole FLAP inhibitor MK-886. Compounds 23 and 30 inhibit mPGES-1 with potencies in the low nanomolar range and with selec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f0247c709881dfdb5299cd4f4783442
https://doi.org/10.1016/j.bmcl.2005.05.027
https://doi.org/10.1016/j.bmcl.2005.05.027
Autor:
Panagiota B. Stamatiou, Joshua Rokach, Diane Ethier, Guillaume Monneret, Chi-Chung Chan, William S. Powell
Publikováno v:
Journal of Biological Chemistry. 279:28159-28164
Allergic diseases such as asthma are characterized by tissue eosinophilia induced by the combined effects of chemoattractants and cytokines. Lipid mediators are a major class of endogenous chemoattractants, among which 5-oxo-6,8,11,14-eicosatetraenoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc71b413b30e04f0826c1232fb8d51d9
https://doi.org/10.1074/jbc.m401537200
https://doi.org/10.1074/jbc.m401537200