Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Diana Vara"'
Autor:
Alicia Bort, Belén G. Sánchez, Pedro A. Mateos‐Gómez, Diana Vara‐Ciruelos, Nieves Rodríguez‐Henche, Inés Díaz‐Laviada
Publikováno v:
Molecular Oncology, Vol 13, Iss 5, Pp 1311-1331 (2019)
Hepatocellular carcinoma (HCC) is the third leading cause of cancer death worldwide. HCC treatment is hindered by the frequent emergence of chemoresistance to the multikinase inhibitor sorafenib, which has been related to the presence of cancer stem
Externí odkaz:
https://doaj.org/article/e8408f6e3e2247afa66d7c76d863ded4
Publikováno v:
Open Biology, Vol 9, Iss 7 (2019)
The AMP-activated protein kinase (AMPK) acts as a cellular energy sensor. Once switched on by increases in cellular AMP : ATP ratios, it acts to restore energy homeostasis by switching on catabolic pathways while switching off cell growth and prolife
Externí odkaz:
https://doaj.org/article/80c9c9190be44145b1fbeda335455d0c
Autor:
Diana Vara-Ciruelos, Madhumita Dandapani, Fiona M. Russell, Katarzyna M. Grzes, Abdelmadjid Atrih, Marc Foretz, Benoit Viollet, Douglas J. Lamont, Doreen A. Cantrell, D. Grahame Hardie
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 690-698.e4 (2019)
Summary: AMPK acts downstream of the tumor suppressor LKB1, yet its role in cancer has been controversial. AMPK is activated by biguanides, such as metformin and phenformin, and metformin use in diabetics has been associated with reduced cancer risk.
Externí odkaz:
https://doaj.org/article/db8d81d633214b928b39b3ad83b03e1d
Publikováno v:
Cells, Vol 9, Iss 6, p 1441 (2020)
In the past few years, cell plasticity has emerged as a mode of targeted therapy evasion in prostate adenocarcinoma. When exposed to anticancer therapies, tumor cells may switch into a different histological subtype, such as the neuroendocrine phenot
Externí odkaz:
https://doaj.org/article/45a39ee69f474140a9a5567f1ee3b3ab
Autor:
Cecilia Morell, Alicia Bort, Diana Vara-Ciruelos, Ágata Ramos-Torres, Manuel Altamirano-Dimas, Inés Díaz-Laviada, Nieves Rodríguez-Henche
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162977 (2016)
Neuroendocrine (NE) prostate cancer (PCa) is a highly aggressive subtype of prostate cancer associated with resistance to androgen ablation therapy. In this study, we used LNCaP prostate cancer cells cultured in a serum-free medium for 6 days as a NE
Externí odkaz:
https://doaj.org/article/6d133d84d13c4a479c58975617f7497e
Autor:
D. Grahame Hardie, A. Mark Evans, Ejaife O. Egbani, Alexander Gray, Madhumita Dandapani, Diana Vara-Ciruelos
Many genotoxic cancer treatments activate AMP-activated protein kinase (AMPK), but the mechanisms of AMPK activation in response to DNA damage, and its downstream consequences, have been unclear. In this study, etoposide activates the α1 but not the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0ac6dbdb1f022cabfc5c5d3274ad6b4
https://doi.org/10.1158/1541-7786.c.6540435.v1
https://doi.org/10.1158/1541-7786.c.6540435.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
The AMP-activated protein kinase (AMPK) is activated by phosphorylation at Thr172, either by the tumor suppressor kinase LKB1 or by an alternate pathway involving the Ca2+/calmodulin-dependent kinase, CAMKK2. Increases in AMP:ATP and ADP:ATP ratios,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b57d6fa029e3ecaeee2012b9207f6e5
https://doi.org/10.1158/1541-7786.c.6539973.v1
https://doi.org/10.1158/1541-7786.c.6539973.v1
Autor:
D. Grahame Hardie, Graeme J. Gowans, Alexander Gray, Diana Vara Ciruelos, Fiona A. Ross, Sarah Fogarty
Cellular stresses that increase AMP:ATP and AMP:ATP ratios activate AMPK in normal cells by promoting its phosphorylation by LKB1. This triggers inhibition of cell growth by phosphorylation of acetyl-CoA carboxylase (ACC), Raptor and other targets, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f7f096a646d6fa9fa5b00f7f6db98c1
https://doi.org/10.1158/1541-7786.22511550
https://doi.org/10.1158/1541-7786.22511550
Autor:
D. Grahame Hardie, A. Mark Evans, Ejaife O. Egbani, Alexander Gray, Madhumita Dandapani, Diana Vara-Ciruelos
Supplementary Figure S1: Etoposide activates AMPK in the nucleus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a90dda041246fe295ccbdc24f09a8af1
https://doi.org/10.1158/1541-7786.22513104.v1
https://doi.org/10.1158/1541-7786.22513104.v1
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Background Air pollution is of significant environmental and public health concern globally. While much research has historically focused on outdoor air pollution, indoor air pollution has been relatively under-explored despite its strong co
Externí odkaz:
https://doaj.org/article/004017f7cc694ccba32a17f251748d3e