Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Diana V. Atigari"'
Strategies for DevelopingκOpioid Receptor Agonists for the Treatment of Pain with Fewer Side Effects
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 375:332-348
There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor (KOPr) agonists have been studied for decades but have recently received increased attention because of their analgesic effects and lack of abuse potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb2029ce838f45af4c6004925476a1a3
https://doi.org/10.1124/jpet.120.000134
https://doi.org/10.1124/jpet.120.000134
Autor:
Susruta Majumdar, Rajendra Uprety, Bronwyn M. Kivell, Amy F. Alder, Kelly F. Paton, Diana V. Atigari, Brittany Scouller, John H. Miller, András Váradi
Publikováno v:
Neuropharmacology
Effective treatments for chronic pain without abuse liability are urgently needed. One in 5 adults suffer chronic pain and half of these patients report inefficient treatment. Mu opioid receptor agonists (MOP), including oxycodone, tramadol and morph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8347d79430199203ba35e142ec2fedc
https://europepmc.org/articles/PMC8344368/
https://europepmc.org/articles/PMC8344368/
Publikováno v:
J Pharmacol Exp Ther
There is significant need to find effective, nonaddictive pain medications. κ Opioid receptor (KOPr) agonists have been studied for decades but have recently received increased attention because of their analgesic effects and lack of abuse potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5c7f957eb1844094da16be2e6361baf3
https://pubmed.ncbi.nlm.nih.gov/32913006
https://pubmed.ncbi.nlm.nih.gov/32913006
Publikováno v:
Neuropharmacology
Kappa opioid receptor (KOPr) agonists have preclinical anti-cocaine and antinociceptive effects. However, adverse effects including dysphoria, aversion, sedation, anxiety and depression limit their clinical development. MP1104, an analogue of 3-iodob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c65a5cf3bb816b3693ad0e33a095c24e
https://pubmed.ncbi.nlm.nih.gov/30768946
https://pubmed.ncbi.nlm.nih.gov/30768946