Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Diana Spiegelberg"'
Autor:
Katrine Ingelshed, Marit M. Melssen, Pavitra Kannan, Arun Chandramohan, Anthony W. Partridge, Long Jiang, Fredrik Wermeling, David P. Lane, Marika Nestor, Diana Spiegelberg
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109862- (2024)
Summary: Immunotherapy has revolutionized cancer treatment but its efficacy depends on a robust immune response in the tumor. Silencing of the tumor suppressor p53 is common in tumors and can affect the recruitment and activation of different immune
Externí odkaz:
https://doaj.org/article/a6f5c387d3ed4365a35bb503c9592eba
Autor:
Arun Chandramohan, Hubert Josien, Tsz Ying Yuen, Ruchia Duggal, Diana Spiegelberg, Lin Yan, Yu-Chi Angela Juang, Lan Ge, Pietro G. Aronica, Hung Yi Kristal Kaan, Yee Hwee Lim, Andrea Peier, Brad Sherborne, Jerome Hochman, Songnian Lin, Kaustav Biswas, Marika Nestor, Chandra S. Verma, David P. Lane, Tomi K. Sawyer, Robert Garbaccio, Brian Henry, Srinivasaraghavan Kannan, Christopher J. Brown, Charles W. Johannes, Anthony W. Partridge
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Although stapled α-helical peptides can address challenging targets, their advancement is impeded by poor understandings for making them cell permeable while avoiding off-target toxicities. By synthesizing >350 molecules, we present workflo
Externí odkaz:
https://doaj.org/article/244b34e3aef44b508696598d0927724f
Autor:
Anja Charlotte Lundgren Mortensen, Hanna Berglund, Mehran Hariri, Eleftherios Papalanis, Christer Malmberg, Diana Spiegelberg
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Thyroid cancer is the most common endocrine malignancy, affecting nearly 600,000 new patients worldwide. Treatment with the BRAF inhibitor sorafenib partially prolongs progression-free survival in thyroid cancer patients, but fails to improv
Externí odkaz:
https://doaj.org/article/1b59be93ecd2470187a1d6c7f8418bf4
Autor:
Xin Yu Koh, Xiao Hui Koh, Diana Spiegelberg, Preeti Jha, Marika Nestor, Le-ann Hwang, Ban Xiong Tan, David Philip Lane
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The RON receptor tyrosine kinase is an exceptionally interesting target in oncology and immunology. It is not only overexpressed in a wide variety of tumors but also has been shown to be expressed on myeloid cells associated with tumor infil
Externí odkaz:
https://doaj.org/article/7630592839b745e4807f205edee05a36
Ra-223 induces clustered DNA damage and inhibits cell survival in several prostate cancer cell lines
Publikováno v:
Translational Oncology, Vol 26, Iss , Pp 101543- (2022)
The bone-seeking radiopharmaceutical Xofigo (Radium-223 dichloride) has demonstrated both extended survival and palliative effects in treatment of bone metastases in prostate cancer. The alpha-particle emitter Ra-223, targets regions undergoing activ
Externí odkaz:
https://doaj.org/article/f231e47f8e6a4aec88850ffac74aa27d
Publikováno v:
Cancers, Vol 14, Iss 20, p 5161 (2022)
This prospective study identifies high-risk groups for recurrence of head and neck cancer by BMI and circulating inflammatory response markers. Head and neck cancer patients from three Swedish hospitals were included (n = 272). Leukocyte and thromboc
Externí odkaz:
https://doaj.org/article/618edf445f9e420ba4d57815279663cb
Autor:
Diana Spiegelberg, Anja Charlotte Lundgren Mortensen, Kartika Dyah Palupi, Patrick Micke, Julin Wong, Borivoj Vojtesek, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
RationalcMet is abnormally regulated in gastrointestinal cancer, and is associated with increased invasiveness of the disease and poor overall survival. There are indications that targeted therapy against cMet, alone or in combination with additional
Externí odkaz:
https://doaj.org/article/5432d99071b24b57adc1dde95164618e
Autor:
Anja Charlotte Lundgren Mortensen, Tabassom Mohajershojai, Mehran Hariri, Marika Pettersson, Diana Spiegelberg
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
RationalCisplatin based cancer therapy is an affordable and effective standard therapy for several solid cancers, including lung, ovarian and head and neck cancers. However, the clinical use of cisplatin is routinely limited by the development of dru
Externí odkaz:
https://doaj.org/article/fb1832a87a074e8f858bb39f6f985b28
Autor:
Anja Charlotte Lundgren Mortensen, Diana Spiegelberg, Christopher John Brown, David Philip Lane, Marika Nestor
Publikováno v:
Frontiers in Oncology, Vol 9 (2019)
The tumor suppressor p53 is a key mediator of cellular stress and DNA damage response cascades and is activated after exposure to ionizing radiation. Amplifying wild-type p53 expression by targeting negative regulators such as MDM2 in combination wit
Externí odkaz:
https://doaj.org/article/625d8ae824cf4fb8841b5f0c06ec12c1
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94621 (2014)
The cell surface proteins CD133, CD24 and CD44 are putative markers for cancer stem cell populations in colon cancer, associated with aggressive cancer types and poor prognosis. It is important to understand how these markers may predict treatment ou
Externí odkaz:
https://doaj.org/article/79060b185beb4c9ebb70a105ad7a959b