Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Diana Shpektor"'
Autor:
Allan Gurtan, John Dominy, Shareef Khalid, Linh Vong, Shari Caplan, Treeve Currie, Sean Richards, Lindsey Lamarche, Daniel Denning, Diana Shpektor, Anastasia Gurinovich, Asif Rasheed, Shahid Hameed, Subhan Saeed, Imran Saleem, Anjum Jalal, Shahid Abbas, Raffat Sultana, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Nabi Shah, Mohammad Ishaq, Amit V Khera, John Danesh, Philippe Frossard, Danish Saleheen
Publikováno v:
PLoS Genetics, Vol 18, Iss 4, p e1010093 (2022)
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu
Externí odkaz:
https://doaj.org/article/9c0268137d414840bbba8d1073dcccdf
Autor:
Julie Rytlewski, Leanne Peiser, Jerill Thorpe, Heidi Gillenwater, Ken Ogasawara, Yeonhee Kim, Diana Shpektor, Eniko Papp
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/1603585596764915b3aaf112d600f635
Autor:
Diana Shpektor, Daryanaz Dargahi, Antonios Samiotakis, Sara Wienke, Ali Livernois, Arielle Yablonovitch, Geethika Yalamanchili, Elaina Gartner, Funda Meric-Bernstam
Publikováno v:
Cancer Research. 83:CT278-CT278
Background: HER2-targeted therapies have substantially improved outcomes for patients with HER2-positive breast and gastric cancers. Several other cancers exhibit HER2 expression and/or amplification of its gene (ERBB2), suggesting that HER2-targeted
Autor:
Syed Zahed Rasheed, Sean Richards, Asif Rasheed, Nabi Shah, Anastasia Gurinovich, Treeve Currie, Shahid Abbas, Shari L. Caplan, Subhan Saeed, Shareef Khalid, Amit Khera, John Dominy, Linh Vong, Allan Gurtan, Sekar Kathiresan, Daniel Denning, Fazal-ur-Rehman Memon, Lindsey Lamarche, Philippe M. Frossard, Anjum Jalal, John Danesh, Raffat Sultana, Shahid Hameed, M. Ishaq, Danish Saleheen, Imran Saleem, Diana Shpektor
Novel drug targets for sustained reduction in body mass index (BMI) are needed to curb the epidemic of obesity, which affects 650 million individuals worldwide and is a causal driver of cardiovascular and metabolic disease and mortality. Previous stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b5cdeab427812b92c0c210a03d9b26
https://doi.org/10.1101/2021.10.21.21264378
https://doi.org/10.1101/2021.10.21.21264378
Autor:
Diana Shpektor, Eniko Papp, Leanne Peiser, Jerill Thorpe, Yeonhee Kim, Julie A. Rytlewski, Heidi H. Gillenwater, Ken Ogasawara
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundCLL is an incurable hematologic malignancy characterized by progressive accumulation of clonally derived CD19+ B-cell lymphocytes. CAR T cell therapies are promising treatments but inherent T cell dysfunction has limited their development i
Publikováno v:
Journal of Neurochemistry. 74:1858-1869
The ability of nerve cells to regulate the expression of specific neurotransmitter receptors is of central importance to nervous system function, but little is known about the DNA elements that mediate neuron specific gene expression. The type A gamm
Autor:
Eileen Turcott, Ethan W. Ojala, May Kung Sutherland, John A. Latham, David G. Winkler, John Skonier, Diana Shpektor, Changpu Yu, James C. Geoghegan
Publikováno v:
Journal of Biological Chemistry. 280:2498-2502
High bone mass diseases are caused both by activating mutations in the Wnt pathway and by loss of SOST, a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. Given the phenotypic similarity between mutations that
Autor:
Alison Wallace, Paul Kodama, John F. Valliere-Douglass, Diana Shpektor, Robert Bailey, Laura Jones, Alain Balland, Yuling Zhang
Publikováno v:
Analytical chemistry. 80(9)
Hydrophobic interaction chromatography (HIC) was used to separate populations of recombinant IgG2 antibody that were created as a result of prolonged incubation at 40 degrees C. Antibody was separated by HIC into three major and seven minor fractions
Autor:
John Skonier, Diana Shpektor, Ethan W. Ojala, John A. Latham, Changpu Yu, May Kung Sutherland, James C. Geoghegan, David G. Winkler
Publikováno v:
The Journal of biological chemistry. 279(35)
Noggin and sclerostin are bone morphogenetic protein (BMP) antagonists that modulate mitogenic activity through sequestering BMPs. Little is known of the interactions among this class of proteins. We show that recombinant sclerostin and noggin bound
Autor:
James C. Geoghegan, Trenton Hayes, John Skonier, John A. Latham, Mark Appleby, Karen Staehling-Hampton, Mechtild Jonas, David G. Winkler, May Kung Sutherland, Brian Kovacevich, Mary E. Brunkow, Changpu Yu, Diana Shpektor
Publikováno v:
The EMBO journal. 22(23)
There is an unmet medical need for anabolic treatments to restore lost bone. Human genetic bone disorders provide insight into bone regulatory processes. Sclerosteosis is a disease typified by high bone mass due to the loss of SOST expression. Sclero